Production methodologies of polymeric and hydrogel particles for drug delivery applications

Lima, Amanda Camerini; Sher, Praveen; Mano, João F.

doi:10.1517/17425247.2012.652614

Cited by 99 publications

(71 citation statements)

References 93 publications

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“…[ 65,66 ] Control of the particle size depends on the production method utilized, which in turn should be adequate to the materials to be used. Volumes of the precursor solutions dispensed by nozzles, micropipettes, spraying systems, or the mixing conditions (stirring, sonication, vortexing) control the size of the particles obtained.…”

Section: Sizementioning

confidence: 99%

Design Advances in Particulate Systems for Biomedical Applications

Lima

Álvarez-Lorenzo

Mano

2016

Adv Healthcare Materials

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Particulate systems have been widely used as containers of drugs or cells with the purpose of releasing them in a particularThe search for more effi cient therapeutic strategies and diagnosis tools is a continuous challenge. Advances in understanding the biological mechanisms behind diseases and tissues regeneration have widened the fi eld of applications of particulate systems. Particles are no more just protective systems for the encapsulated drugs, but they play an active role in the success of the therapy. Moreover, particles have been explored for innovative purposes as templates for cells growth and as diagnostic tools. Until few years ago the most relevant parameters in particles formulation were the chemistry and the size. Currently, it is known that other physical characteristics can remarkably affect the performance of particulate systems. Particles with non-conventional shapes exhibit advantages due to the increasing circulation time in blood stream, less clearance by the immune system and more effi cient cell internalization and traffi cking. Creation of compartments has been found useful to control drug release, to tune the transport of substances across biological barriers, to supply the target with more than one bioactive agent or even to act as theranostic systems. It is expected that such complex shaped and compartmentalized systems improve the therapeutic outcomes and also the patient's compliance, acting as advanced devices that serve for simultaneous diagnosis and treatment of the disease, combining agents of very different features, at the same time. In this review, we overview and analyse the most recent advances in particle shape and compartmentalization and applications of newly designed particulate systems in the biomedical fi eld.

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Section: Sizementioning

confidence: 99%

Design Advances in Particulate Systems for Biomedical Applications

Lima

Álvarez-Lorenzo

Mano

2016

Adv Healthcare Materials

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“…At region of 1730 cm −1 it is possible to observe C = O stretching [10]. The peak in 1431 cm −1 and 1135 cm −1 indicate the presence of CH-OH [27] also in 1381 cm −1 peak is due to CH asymmetrical bending [26], and in the region of 1095 cm −1 correspond to CO linkage [24]. In Figure 4(B) is displayed the GG2% hydrogel spectra showing the following peaks in the region 3432 cm −1 that correspond the OH group as shown before in the PVA hydrogel; 1620 cm −1 due to bending vibration of hydroxyl group, 1462 due to CH asymmetrical bending [28].…”

Section: Ftir Analysis Of Hydrogel Compositesmentioning

confidence: 89%

“…Recovered buffer was soni-cated to disrupt residual hydrogel before Uv-vis analysis (Uv-vis Hitachi U-3900). The swelling ratio, DSw, of each type of composite were determined by accurately weighing each gel sample in the stability study after the HEPES buffer had been removed, correcting for residual buffer, and dividing by the original hydrated sample mass [24]- [26]. To compare the degradation of composites with different swelling characteristics, normalized DSw was defined as:…”

Section: In Vitro Stability and Swelling Of Biodegradable Hydrogel Comentioning

confidence: 99%

Gold Nanoparticle and Berberine Entrapped into Hydrogel Matrix as Drug Delivery System

Souza¹,

Oliveira²,

Pinheiro³

et al. 2015

JBNB

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In this study the novel hydrogel loaded with gold nanoparticle (AuNP) enhanced the berberine (BS) release when compared with other formulations of hydrogel. Hydrogels are hydrophilic polymer networks having the capacity to absorb water, ranging from about twenty to thousand times their dry weight. BS is a natural product, a quaternary ammonium salt from the group of isoquinoline alkaloids found in medicinal plants as Berberis Vulgaris. BS has some activity against dysentery, hypertension, inflammation, and liver disease in China and Japan. In this work, BS was used as a model drug to study its association with different types of hydrogel composites of polyvinyl alcohol (BS-PVA 10%); gellan gum (BS-GG 2%), gellan gum-PVA crosslinked with cysteine (cys) (BSGG2%PVA2%cys) and gellan gum-PVA cosslinked with cysteine associated with gold nanoparticles (AuNP-BSGG2%PVA2%cys). Several parameters such as fraction of retained water (Wf), hydration percentage (%H), Swelling (DSw) and time course profile (t = 100%) (TC) were evaluated for all preparations. The results showed that the AuNP-BS-GG2%PVA2%cys was able to retain more water and swelling than the other preparations. The time course of release of the BS to the medium was greater for AuNP-BS-GG2%PVA2%cys making it a candidate to drug delivery studies in biological assays. Also Scanning Electron Microscopy (SEM) images of the surface of these hydrogel were performed. Furthermore, crosslink of the resulting hydrogels were investigated by Fourier Transform Infrared Spectroscopy (FTIR) and differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). Thus, briefly, the aim of this work was to study three composition of hydrogel loaded with BS and its composition in relation to addition to AuNP and evaluate its profile for further drug delivery application using the Surface Plasmonic Resonance (SPR) as a tool improving the drug release in the new hydrogel. * Corresponding authors. C. Rufino Souza et al.54

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“…Polymeric particles are ideal vehicles for controlled delivery applications because of their ability to encapsulate a variety of substances, namely low-and high-molecular-mass therapeutics, antigens, or DNA [105]. Moreover, polymeric microparticles have been applied in tissue engineering, as building blocks of hybrid structures and matrices for the delivery of soluble factors, either by fusion giving rise to porous scaffolds or as injectable systems for in situ scaffold formation [106].…”

Section: Substrates For Preparing Hydrogel and Polymeric Particlesmentioning

confidence: 99%

Surfaces with Extreme Wettability Ranges for Biomedical Applications

Song¹,

Alves²,

Mano³

2012

Biomimetic Approaches for Biomaterials Development

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Learning from nature has become a shortcut to synthesize new materials or to improve their properties for different applications [1][2][3][4][5][6]. In particular, surfaces with extreme wettability found in nature have attracted great interest because they can find applications in industry, agriculture, and daily life [7,8]. Among them, superhydrophobic surfaces, that is, those that show a water contact angle (WCA) >150 • and a sliding angle <5 • have been especially investigated in recent years [9] because of the foreseeable applications in biomedicine and tissue engineering. One can find this unique property in many plants or insects, as shown in Figure 10.1, such as in lotus leaves, legs of water strider, butterfly wings, and moth or mosquito eyes [10-13]. The lotus leaf, the most well-known example of superhydrophobicity in nature, also presents the so-called self-cleaning effect, as reported by Barthlott and Ehler in 1977 for the first time [14]. Furthermore, surface analysis indicates that the lotus leaf surface is full of micropapillae and that nanoscale structures can be observed on each papilla. These hierarchical micro-and nanostructures and the covered thin layer of biowax are responsible for the superhydrophobicity of the lotus leaves. This kind of surface is also called isotropic superhydrophobic surface because of the isotropy of the surface roughness geometry. Anisotropic superhydrophobic surfaces can also be found in nature, for example, a wheat leaf or a butterfly wing, in which wettability changes with the direction [15,16]. These surfaces could be widely used for designing new microfluidic [17] and bioanalyzing devices that require directional (2D) and spatial (3D) variations of controlled wettability, adhesive force, and friction force. Regarding the superhydrophobic cases of insects in nature, and taking the water strider as an example, the ability to ''walk'' on water surface has been attributed to the combined action of the covered biowax and the nano/microscale hierarchical structures of the small hairs (setae) on the legs [18,19].From the previous examples taken from nature, it is clear that the special hierarchical micro-and nanostructures are the determinants of the superhydrophobicity of a surface. Because the adhesion of cells or proteins on a surface is also affected by the surface wettability, these special hierarchical structures can be foreseen to Biomimetic Approaches for Biomaterials Development, First Edition. Edited by João F. Mano.

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Production methodologies of polymeric and hydrogel particles for drug delivery applications

Cited by 99 publications

References 93 publications

Design Advances in Particulate Systems for Biomedical Applications

Design Advances in Particulate Systems for Biomedical Applications

Gold Nanoparticle and Berberine Entrapped into Hydrogel Matrix as Drug Delivery System

Surfaces with Extreme Wettability Ranges for Biomedical Applications

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