Production improvement of an antioxidant in cariogenic Streptococcus mutans UA140
Shuyu Li,
Yuwei Zhang,
Jianfa Zong
et al.
Abstract:Aims
This study aimed to improve the production of mutantioxidin, an antioxidant encoded by a biosynthetic gene cluster (mao) in Streptococcus mutans UA140, through a series of optimization methods.
Method and results
Through construction of mao knockout strain S. mutans UA140∆mao, we identified mutantioxidin as the antioxidant encoded by mao and verified its antioxidant activity through a ROS tolerance assay. By optimizing t… Show more
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