1990
DOI: 10.1073/pnas.87.14.5484
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Production by activated human T cells of interleukin 4 but not interferon-gamma is associated with elevated levels of serum antibodies to activating malaria antigens.

Abstract: T cells play a crucial role in antibodymediated and antibody-independent immunity against Plasmodium falciparum malaria. Therefore, a vaccine immunogen should include parasite-derived B-and T-cell epitopes capable of giving rise to protective responses in both systems. The P.falciparum antigen PfI55/ring-infected erythrocyte surface antigen (RESA), a vaccine candidate, contains immunodominant T-and B-cell epitopes located in the central (5') and C-terminal (3') invariant repeat regions of the molecule. To rela… Show more

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Cited by 90 publications
(72 citation statements)
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“…Activation of IL-4-producing T cell subsets and production of malaria-specific antibodies have been reported previously. 15 Interleukin-4 is also involved in the induction of isotype switching from IgM to IgG1, IgG4, and IgE. 16 Since type 2 responses are associated with the development of humoral immunity, specifically with antibody isotype switching to IgG1, our observation of greater expression of IL-4 during repeat infection seemed consistent with previous studies.…”
Section: Discussionsupporting
confidence: 82%
“…Activation of IL-4-producing T cell subsets and production of malaria-specific antibodies have been reported previously. 15 Interleukin-4 is also involved in the induction of isotype switching from IgM to IgG1, IgG4, and IgE. 16 Since type 2 responses are associated with the development of humoral immunity, specifically with antibody isotype switching to IgG1, our observation of greater expression of IL-4 during repeat infection seemed consistent with previous studies.…”
Section: Discussionsupporting
confidence: 82%
“…We reported earlier that the P. falciparum blood stage vaccine candidate antigen, Pf155/RESA, stimulates T cells from P. falciparum-primed donors to proliferate, and to produce IFN-g and/or IL-4 [10]. Importantly, in most instances these three activities were not correlated in individual donors.…”
Section: Discussionmentioning
confidence: 99%
“…In human P. falciparum malaria we have shown earlier that CD4 + T cells from donors primed by natural infection produce IFN-g and/or IL-4 after in vitro exposure to defined malarial peptides. IL-4 production by primed T cells was accompanied by elevated serum levels of antibodies specific for the P. falciparum peptides used for T cell stimulation [10].…”
Section: Introductionmentioning
confidence: 99%
“…The formation of these antibodies is controlled by IL-4, produced by CD4' T cells of the Th2 variety [1][2][3]. In human Plasmodium falciparum malaria, we have shown that stimulation of CD4' T cells from immune donors with malaria antigen in vitro frequently induced either IFN-7 or lL-4 secretion, indicating the occurrence of distinct Thl-or Th2-like cells in the blood of these individuals [4]. As IL-4 is involved in switching immunoglobulin isotype production by B cells from IgM to IgE [5][6][7][8] we considered it of interest to investigate the occurrence and possible role of IgE in the development of immunity to P. falciparum malaria.…”
Section: Introductionmentioning
confidence: 97%