Production and stability study of a hospital parenteral nutrition solution for neonates

Yailian, Anne-Laure; Serre, Céline; Fayard, Justine; Faucon, Marina; Thomare, P.; Filali, Samira; Pivot, C.; Vételé, Florence; Pirot, Fabrice; Olivier, E.

doi:10.1016/j.jpha.2018.01.002

Cited by 11 publications

(7 citation statements)

References 25 publications

(27 reference statements)

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“…e particle size and distribution of the fat emulsion did not change. e stability of parenteral nutrition solution mainly depends on the stability of fat emulsion, so it is very important to understand the stability of fat emulsion [6][7][8][9][10]. At present, some studies on the stability of parenteral nutrition for adults have been reported at home and abroad, but there are no reports on the stability of parenteral nutrition for newborns.…”

Section: Introductionmentioning

confidence: 99%

Data Mining-Based Stability and Prescription Analysis of Neonatal Parenteral Nutrition Solution

Fan

Han

et al. 2021

Journal of Healthcare Engineering

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In order to evaluate the stability of neonatal parenteral nutrition solution, in this paper, the prescription of neonatal parenteral nutrition solution was investigated and analyzed. The formula of neonatal parenteral nutrition solution used, particularly the one utilized in this study, is commonly used in clinical practice. All the neonatal parenteral nutrition solution required for the test was prepared on the purification workbench in a sterile environment. The time points of stability of parenteral nutrient solution were 0, 12, and 24 hours, respectively, and three parallel samples were taken at each time point. Likewise, to investigate the stability of two kinds of fat milk injection in parenteral nutrition solution of neonates and provide a reference for subsequent experiments and to investigate the influence of electrolyte, amino acid, temperature, pH value, mixing sequence, and the final concentration of glucose on the stability of neonatal parenteral nutrition solution, the stability indexes of neonatal parenteral nutrition liquid mainly include appearance, pH, insoluble particles, fat milk particle size, and particle size distribution. Neonatal parenteral nutrition solution prescriptions from the First Affiliated Hospital of Jinan University, specifically from January to June 2019, were collected and statistically processed. The experimental data were processed by SPSS 19.0 software and data mining technology. The results were expressed as mean ± standard deviation and statistically processed by ANOVA. P < 0.05 was considered statistically significant. The results showed that the stability of neonatal parenteral nutrient solution was influenced by many factors. The formula of neonatal parenteral nutrition solution is generally reasonable, but there are unreasonable phenomena which are needed to be improved further if feasible.

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Section: Introductionmentioning

confidence: 99%

Data Mining-Based Stability and Prescription Analysis of Neonatal Parenteral Nutrition Solution

Fan

Han

et al. 2021

Journal of Healthcare Engineering

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“…This phenomenon is generally attributed to Maillard’s reaction and the degradation of the amino acids they contain, especially lysine, glycine and methionine 19 . Nonetheless, Yailian et al showed that PNS became first more yellow than brown, and linked it to the increased presence of cysteine, which is the oxidized dimer form l -cysteine 20 . This information validates the use of the European Pharmacopoeia set of colors B (brown) and Y (yellow) as references for the visual examination for respectively the paracetamol and PNS formulations.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of color changes during stability studies using spectrophotometric chromaticity measurements versus visual examination

Sakiroff

Chennell

Yessaad

et al. 2022

Sci Rep

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Stability studies are essential to be able to assign an expiration date to medications. Color variation is one of the organoleptic characteristics of actives substances or medications which can indicate the presence of contaminations, impurities or degradations products. However there is no data available comparing the often used visual examination with spectrophotometric measurements during stability studies. The aim of this study was therefore to evaluate precisely how different the two methods are, by comparing the change of color of two drug formulations chosen as models, assessed by visual examination versus a spectrophotometric colorimetric analysis. Paracetamol and parenteral nutrition solutions were stored in stress conditions for up to 46 days, and were subjected to a visual examination using color reference solutions and to lightness and chromaticity measurement to determine their specific color by UV–Vis spectrophotometry. The color of paracetamol solutions changed faster when exposed to stress condition (light), as did the PNS when exposed to heat. In both cases, color variations were detected earlier and more precisely by UV–Vis spectrophotometry than by visual examination. Color measurement using an UV–Vis spectrophotometry should advantageously replace visual examination when assessing colors changes during drug stability studies.

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“…Within TPN, amino acids are typically stable for about four months at 2–8 °C, except for cysteine, which slowly dimerizes to yield cystine, giving a yellow discoloration of parenteral solutions with storage time [ 107 ]. Pitkänen et al [ 108 ] reported that lipid degradation and the production of oxidants were high during the storage of Intralipid.…”

Section: Parenteral Nutrition and Environmental Conditionsmentioning

confidence: 99%

Parenteral Nutrition and Oxidant Load in Neonates

2021

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Neonates with preterm, gastrointestinal dysfunction and very low birth weights are often intolerant to oral feeding. In such infants, the provision of nutrients via parenteral nutrition (PN) becomes necessary for short-term survival, as well as long-term health. However, the elemental nutrients in PN can be a major source of oxidants due to interactions between nutrients, imbalances of anti- and pro-oxidants, and environmental conditions. Moreover, neonates fed PN are at greater risk of oxidative stress, not only from dietary sources, but also because of immature antioxidant defences. Various interventions can lower the oxidant load in PN, including the supplementation of PN with antioxidant vitamins, glutathione, additional arginine and additional cysteine; reduced levels of pro-oxidant nutrients such as iron; protection from light and oxygen; and proper storage temperature. This narrative review of published data provides insight to oxidant molecules generated in PN, nutrient sources of oxidants, and measures to minimize oxidant levels.

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Production and stability study of a hospital parenteral nutrition solution for neonates

Cited by 11 publications

References 25 publications

Data Mining-Based Stability and Prescription Analysis of Neonatal Parenteral Nutrition Solution

Data Mining-Based Stability and Prescription Analysis of Neonatal Parenteral Nutrition Solution

Evaluation of color changes during stability studies using spectrophotometric chromaticity measurements versus visual examination

Parenteral Nutrition and Oxidant Load in Neonates

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