Production and role of plants secondary metabolites under various environmental pollution

Alugoju, Phaniendra; Tencomnao, Tewin

doi:10.1016/b978-0-323-99978-6.00018-2

Cited by 2 publications

(2 citation statements)

References 156 publications

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“…Ocimum tenuiflorum or Phyllanthus amarus were cultivated in Cr-polluted soil, resulting in a significant increase in phenolic compounds, such as eugenol or hypophyllathin [ 64 ]. Moreover, eugenol was reported as having an inhibitory effect on NorA efflux pumps when combined with norfloxacin in S.aureus .…”

Section: Secondary Metabolites Production Of Plants As Potential Epismentioning

confidence: 99%

“…In 1999, Singh et al reported that a decoction of Pteris vittata was effective in the treatment of dysentery [ 63 ]. In 2008, Singh et al also showed that this fern contains rutin, which is known to have the ability to fight microorganisms that cause gastrointestinal diseases [ 64 ]. In addition, some other studies have also described the composition of P. vittata , with glycosides of apigenin, luteolin, quercetin, kaempferol, leucocyanidin, and leucodelphinidin [ 65 ].…”

Section: Secondary Metabolites Production Of Plants As Potential Epismentioning

confidence: 99%

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Efflux Pump Inhibitors in Controlling Antibiotic Resistance: Outlook under a Heavy Metal Contamination Context

Nguyen

et al. 2023

Molecules

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Multi-drug resistance to antibiotics represents a growing challenge in treating infectious diseases. Outside the hospital, bacteria with the multi-drug resistance (MDR) phenotype have an increased prevalence in anthropized environments, thus implying that chemical stresses, such as metals, hydrocarbons, organic compounds, etc., are the source of such resistance. There is a developing hypothesis regarding the role of metal contamination in terrestrial and aquatic environments as a selective agent in the proliferation of antibiotic resistance caused by the co-selection of antibiotic and metal resistance genes carried by transmissible plasmids and/or associated with transposons. Efflux pumps are also known to be involved in either antibiotic or metal resistance. In order to deal with these situations, microorganisms use an effective strategy that includes a range of expressions based on biochemical and genetic mechanisms. The data from numerous studies suggest that heavy metal contamination could affect the dissemination of antibiotic-resistant genes. Environmental pollution caused by anthropogenic activities could lead to mutagenesis based on the synergy between antibiotic efficacy and the acquired resistance mechanism under stressors. Moreover, the acquired resistance includes plasmid-encoded specific efflux pumps. Soil microbiomes have been reported as reservoirs of resistance genes that are available for exchange with pathogenic bacteria. Importantly, metal-contaminated soil is a selective agent that proliferates antibiotic resistance through efflux pumps. Thus, the use of multi-drug efflux pump inhibitors (EPIs) originating from natural plants or synthetic compounds is a promising approach for restoring the efficacy of existing antibiotics, even though they face a lot of challenges.

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Section: Secondary Metabolites Production Of Plants As Potential Epismentioning

confidence: 99%

Section: Secondary Metabolites Production Of Plants As Potential Epismentioning

confidence: 99%

Efflux Pump Inhibitors in Controlling Antibiotic Resistance: Outlook under a Heavy Metal Contamination Context

Nguyen

et al. 2023

Molecules

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Exploring redox imbalance and inflammation for asthma therapy

et al. 2023

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Production and role of plants secondary metabolites under various environmental pollution

Cited by 2 publications

References 156 publications

Efflux Pump Inhibitors in Controlling Antibiotic Resistance: Outlook under a Heavy Metal Contamination Context

Efflux Pump Inhibitors in Controlling Antibiotic Resistance: Outlook under a Heavy Metal Contamination Context

Exploring redox imbalance and inflammation for asthma therapy

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