“…Plasminogen circulates at high concentration (2 μM) (Collen & Verstraete, 1975) and liver is well known to be the major site of synthesis (Bohmfalk & Fuller, 1980; Saito et al, 1980). Plasminogen is also expressed at low levels extrahepatically in a number of tissues including brain (Tsirka et al, 1997; Basham & Seeds, 2001; Sappino et al, 1993; Zhang et al, 2002a), adrenal, kidney, testis, heart, lung, uterus, spleen, thymus, gut (Zhang et al, 2002b) and cornea (Twining et al, 1999).…”