2002
DOI: 10.1006/prep.2001.1556
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Production and Purification of a Recombinant Staphylococcal Enterotoxin B Vaccine Candidate Expressed in Escherichia coli

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Cited by 35 publications
(26 citation statements)
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“…Female BALB/c mice (6 to 8 weeks old) were obtained from the National Cancer Institute (Frederick, MD). The rSEBv was produced under GMP conditions as previously reported (8). Endotoxin-free, wild-type (wt) SEB was supplied by Defense Science and Technology Laboratory (Salisbury, United Kingdom).…”
Section: Methodsmentioning
confidence: 99%
“…Female BALB/c mice (6 to 8 weeks old) were obtained from the National Cancer Institute (Frederick, MD). The rSEBv was produced under GMP conditions as previously reported (8). Endotoxin-free, wild-type (wt) SEB was supplied by Defense Science and Technology Laboratory (Salisbury, United Kingdom).…”
Section: Methodsmentioning
confidence: 99%
“…These mutant forms of SEB have been designed and tested based on the considerable data defining the structure-function relationships for this toxin (13,22,23). Specifically, several studies have focused on the role of particular amino acid residues in SEB that are important in toxinogenic activity (1,3,5,15,24,32,34). Most staphylococcal superantigens have common structures for binding to a subunit of the human MHC class II molecule (34).…”
mentioning
confidence: 99%
“…The recombinant staphylococcal enterotoxin B (rSEB) recombinant purified protein mutant derivative was manufactured under current good manufacturing practices (cGMP) at the Pilot Bioproduction Facility of the Walter Reed Army Institute of Research (Silver Spring, MD), using the same procedures previously reported (8,15). The study vaccine vials (lot no.…”
Section: Methodsmentioning
confidence: 99%