Production and physicochemical characterization of bacterial poly gamma- (glutamic acid) to investigate its performance on enhanced oil recovery

Azarhava, Hadi; Bajestani, Maryam Ijadi; Jafari, Arezou; Vakilchap, Farzane; Mousavi, Seyyed Mohammad

doi:10.1016/j.ijbiomac.2019.10.090

Cited by 19 publications

(8 citation statements)

References 39 publications

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“…44 The thermogram of γ-PGA shows a broad endothermic peak at 100 °C, which can be attributed to the crystallization temperature of the substance (phase transition temperature). 52,53 The following exothermic peak at 290 °C and endothermic peak at 337 °C are ascribed to the depolymerization and melting processes of γ-PGA. It has been reported that the thermal behavior of γ-PGA depends on the molecular weight of γ-PGA and its source.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

Biodegradable Local Chemotherapy Platform with Prolonged and Controlled Release of Doxorubicin for the Prevention of Local Tumor Recurrence

Voznyuk,

Makarets,

Advakhova

et al. 2024

ACS Appl. Bio Mater.

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Local recurrence after surgical and therapeutic treatment remains a significant clinical problem in oncology. Recurrence may be due to imperfections in existing therapies, particularly chemotherapy. To improve antitumor activity and prevent local cancer recurrence while keeping toxicity at acceptable levels, we have developed and demonstrated a biodegradable local chemotherapy platform that provides controlled and prolonged drug release. The platform consists of a polycaprolactone (PCL) substrate, which provides the structural integrity of the platform and the predominant unidirectional drug release, and a thin multilayer coating (∼200 nm) containing doxorubicin (DOX). The coating is an electrostatic complex obtained by the layer-bylayer (LbL) assembly and consists of natural polyelectrolytes [poly-γ-glutamic acid (γ-PGA) and chitosan (CS) or poly-L-lysine (PLL)]. To improve the release stability, an ionic conjugate of DOX and γ-PGA was prepared and incorporated into the multilayer coating. By varying the structure of the coating by adding empty (without DOX) bilayers, we were able to control the kinetics of drug release. The resulting platforms contained equal numbers of empty bilayers and DOX-loaded bilayers (15 + 15 or 30 + 30 bilayers) with a maximum loading of 566 ng/cm 2 . The platforms demonstrated prolonged and fairly uniform drug release for more than 5 months while retaining antitumor activity in vitro on ovarian cancer cells (SKOV-3). The empty platforms (without DOX) showed good cytocompatibility and no cytotoxicity to human fibroblasts and SKOV-3 cells. This study presents the development of a local chemotherapy platform consisting of a PCL-based substrate which provides structural stability and a biodegradable polyelectrolyte layered coating which combines layers containing a polyanion ionic complex with DOX with empty bilayers to ensure prolonged and controlled drug release. Our results may provide a basis for improving the efficacy of chemotherapy using drug delivery systems.

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Section: ■ Materials and Methodsmentioning

confidence: 99%

Biodegradable Local Chemotherapy Platform with Prolonged and Controlled Release of Doxorubicin for the Prevention of Local Tumor Recurrence

Voznyuk,

Makarets,

Advakhova

et al. 2024

ACS Appl. Bio Mater.

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“…The porosity of the glass micromodel and oil recovery enhancement were measured with the image processing technique 17 . The captured images were analyzed using the image processing of Matlab software and then, the results were compared with that obtained from Photoshop.…”

Section: Methodsmentioning

confidence: 99%

“…Moreover, biopolymers have been developed for soil stabilization and proved to be effective for shear stress, hardness, soil remediation, and erosion control. 17 Biopolymers are not sensitive to high salinity, but displays sensitivity to biodegradation. Extra oil can be produced by applying biopolymers rather than other chemical substances.…”

Section: Introductionmentioning

confidence: 99%

“…Besides, considering previous research, 14–16 biopolymers can be an alternative for irresolvable plastic and are quite friendly for the environment and affordable. Moreover, biopolymers have been developed for soil stabilization and proved to be effective for shear stress, hardness, soil remediation, and erosion control 17 . Biopolymers are not sensitive to high salinity, but displays sensitivity to biodegradation.…”

Section: Introductionmentioning

confidence: 99%

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Performance evaluation of produced biopolymers by native strains on enhanced oil recovery

Kaboli

Jafari

Azarhava

et al. 2022

J of Applied Polymer Sci

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Bio(polymer) flooding is one of the most promising strategy used to recover additional oil from mature reservoirs. Bio(polymers) decrease the mobility ratio, improving the sweep efficiency of injected fluid and consequently, increasing oil recovery. Therefore, in this research seven unknown strains were isolated from the soil of the Masjed-Soleiman oil field, and then studied for biopolymer production. After biopolymer production and viscosity tests, two of the best strains were selected. Their performances were evaluated in the enhanced oil recovery in micromodel media. The main purpose of this research is to identify the biopolymer-producing species, but the effective parameters in the production of more biopolymers and enhanced oil recovery are also evaluated and optimized. The experiments optimized by the Design Expert software by the general factorial method. The parameters evaluated include different types of strains, biopolymer concentration (three levels of 500, 5500, and 10,500 ppm) and the salinity of the injected fluid (three levels of 0%, 0.5%, and 10%). The best performance in oil recovery for both strains of TMU57 and TMU59 are considered in the biopolymer concentration of 10,500 ppm and the concentration of NaCl equal to 10 wt%. The values of the ultimate oil recovery in these conditions with the strains of TMU57 and TMU59 were 47% and 63%, respectively.

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“…These mechanisms include the reduction of oil viscosity, wettability modification, microbial plugging, reducing IFT, long hydrocarbon chain breakdown, and release of acids [14,17], as shown in Table 1. Azarhava et al [61] reported that when Bacillus licheniformis LMG 7559 was injected into the oil-saturated heterogeneous porous medium, it secreted extracellular Poly gamma-(glutamic acid), which enabled oil recovery of up to 31.45% using biopolymer flooding. Another study by Ashish and Debnath [62] stated that, when used in a sand-packed method, Candida tropicalis MTCC230 secretes a biosurfactant, namely, lipopeptide surfactin, leading to oil recovery of 39.80%.…”

Section: Microbial Metabolic Products Involvedmentioning

confidence: 99%

Exploiting Microbes in the Petroleum Field: Analyzing the Credibility of Microbial Enhanced Oil Recovery (MEOR)

et al. 2021

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Crude oil is a major energy source that is exploited globally to achieve economic growth. To meet the growing demands for oil, in an environment of stringent environmental regulations and economic and technical pressure, industries have been required to develop novel oil salvaging techniques. The remaining ~70% of the world’s conventional oil (one-third of the available total petroleum) is trapped in depleted and marginal reservoirs, and could thus be potentially recovered and used. The only means of extracting this oil is via microbial enhanced oil recovery (MEOR). This tertiary oil recovery method employs indigenous microorganisms and their metabolic products to enhance oil mobilization. Although a significant amount of research has been undertaken on MEOR, the absence of convincing evidence has contributed to the petroleum industry’s low interest, as evidenced by the issuance of 400+ patents on MEOR that have not been accepted by this sector. The majority of the world’s MEOR field trials are briefly described in this review. However, the presented research fails to provide valid verification that the microbial system has the potential to address the identified constraints. Rather than promising certainty, MEOR will persist as an unverified concept unless further research and investigations are carried out.

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Production and physicochemical characterization of bacterial poly gamma- (glutamic acid) to investigate its performance on enhanced oil recovery

Cited by 19 publications

References 39 publications

Biodegradable Local Chemotherapy Platform with Prolonged and Controlled Release of Doxorubicin for the Prevention of Local Tumor Recurrence

Biodegradable Local Chemotherapy Platform with Prolonged and Controlled Release of Doxorubicin for the Prevention of Local Tumor Recurrence

Performance evaluation of produced biopolymers by native strains on enhanced oil recovery

Exploiting Microbes in the Petroleum Field: Analyzing the Credibility of Microbial Enhanced Oil Recovery (MEOR)

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