Production and Functionalization of P(MMA‐co‐AA) Nanoparticles by Miniemulsion Polymerization

Campos, Izabella Maria Ferreira; Ferraz, Helen Conceição; Pinto, José Carlos

doi:10.1002/masy.201600029

Cited by 12 publications

(6 citation statements)

References 22 publications

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“…These concentrations were defined in accordance with previous MMA miniemulsion polymerization studies. [8,16,29,30] The initial miniemulsions were prepared with a sonifier (Branson 450, Marshall Scintific, Hampton, USA) at 160 W for 5 min or with an ultra-turrax (T10 basic, IKA, Staufen, Germany) for 5 min at 14,500 rpm, using an ice bath to control the temperature of the emulsified system and keep it close to room temperature. The polymerizations were conducted in a 100 mL glass reactor (EasyMax 102, Mettler Toledo, Ohio, USA) at 80 o C under the agitation of 500 rpm for 180 min.…”

Section: Polymerization Reactionsmentioning

confidence: 99%

Effects of Different Stabilizers on Miniemulsion Methyl Methacrylate Polymerizations

Alves

Mangia

Sousa-Batista

et al. 2020

Macromolecular Symposia

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The present work evaluated the effects of different ionic and nonionic stabilizers and respective concentrations on methyl methacrylate (MMA) miniemulsion polymerizations. The stabilities of the prepared miniemulsions are characterized through sedimentation and phase separation analyses and afterwards polymerizations are performed at the most stable conditions for each analyzed stabilizer. Monomer conversion profiles and final product properties are determined for comparative purposes. Obtained results indicated that the performances of the stabilizers during the polymerizations are not necessarily related to the stabilizing performances observed during preparation of the miniemulsions and that polymer latexes produced with the nonionic surfactant Tween80 presented the most suitable properties for applications in the biomedical field, as this stabilizer presented good stabilizing performances both during miniemulsion preparation and miniemulsion polymerization.

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Section: Polymerization Reactionsmentioning

confidence: 99%

Effects of Different Stabilizers on Miniemulsion Methyl Methacrylate Polymerizations

Alves

Mangia

Sousa-Batista

et al. 2020

Macromolecular Symposia

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“…[5,24,25] Miniemulsion polymerizations have been used extensively for manufacture of polymer nanoparticles. [26][27][28] This technique presents many competitive advantages, including the fact that use of toxic solvents is not necessary, the high stability of obtained polymer latex and the possibility to perform the encapsulation of chemicals in situ. A typical formulation comprises two phases: the dispersant aqueous phase and the emulsified organic phase, which contains monomers and co-stabilizers.…”

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confidence: 99%

In situ encapsulation of praziquantel through methyl methacrylate/diethylaminoethyl methacrylate and MMA/DMAEMA miniemulsion copolymerizations in presence of distinct ionic surfactants

et al. 2021

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Schistosomiasis is a neglected tropical disease that affects primarily the poorest and most vulnerable populations. Although praziquantel (PZQ) is the drug used most frequently for treatment of schistosomiasis, PZQ presents unpleasant bitter taste and low solubility in water, which prejudice the implementation of pediatric treatments. For this reason, the main purpose of the present work was the production of stable nanoparticles loaded with PZQ through in situ miniemulsion copolymerizations of methyl methacrylate (MMA) with diethylaminoethyl methacrylate (DEAEMA) or dimethylaminoethyl methacrylate (DMAEMA). Due to the cationic nature of the comonomers, the use of different ionic surfactants was also investigated. Nanoparticles with narrow particle size distributions, characteristic average diameters ranging from 50 nm to 110 nm, and loaded with 20 wt% of PZQ were manufactured successfully PZQ encapsulation efficiencies were higher than 97 wt% and PZQ was homogeneously dispersed in the final polymer matrix. Finally, the use of a cationic surfactant with DEAEMA cationic comonomer led to more stable latexes because of the high absolute value of the zeta potential.

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“…First of all, it is important to emphasize that previous works investigated the manufacture of P(MMA‐co‐AA) nanoparticles at distinct conditions and using different AA concentrations,29,38 reporting the copolymer compositions (obtained through nuclear magnetic resonance analyses) and molar mass distributions (obtained through gel permeation chromatography) of the obtained nanoparticles. Besides, scanning electron microscopy (SEM) analyses of the obtained P(MMA‐co‐AA) nanoparticles showed that the obtained particles were spherical, with average sizes of 100 nm and presenting very narrow size distributions 32. According to the recipe presented in Table 1, the final AA content of the obtained copolymer was equal to 1 mol% and the weight‐average molar mass was equal to 1.3 × 10 3 kg mol −1 , with polydispersity of 2.0, as also reported previously.…”

Section: Resultsmentioning

confidence: 99%

P(MMA‐co‐AA) Nanoparticles Loaded with Clioquinol and Functionalized with TAT Peptide

Campos

Barros

Ferraz

et al. 2019

Macro Reaction Engineering

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Polymer nanoparticles produced through miniemulsion polymerizations can be used for design of drug encapsulation and targeted delivery systems. Particularly, the immobilization of functional groups on the surfaces of polymeric nanoparticles enables the development of targeted delivery systems, intended for particle absorption by specific body tissues, favoring the treatment of diseases. For this reason, in the present work poly(methyl methacrylate-co-acrylic acid) (P(MMA-co-AA)) nanoparticles loaded with clioquinol are prepared through in situ miniemulsion polymerizations for the first time. Besides, nanoparticles are functionalized with a cell-penetrating trans-activating transcriptor (TAT) peptide for the first time, to show that incorporation of carboxylic groups (from acrylic acid (AA)) on the particle surfaces provides an effective route for functionalization of nanoparticles with biomolecules. Particularly, it is shown that spherical particles with average sizes between 60 and 100 nm and zeta potential of −50 mV are produced and that the TAT peptide is successfully immobilized onto the particle surfaces. Besides, it is also shown that the clioquinol encapsulation efficiency is equal to 97%. In vitro tests show that 50% of the initial load of clioquinol is released after 9 h of test.

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Production and Functionalization of P(MMA‐co‐AA) Nanoparticles by Miniemulsion Polymerization

Cited by 12 publications

References 22 publications

Effects of Different Stabilizers on Miniemulsion Methyl Methacrylate Polymerizations

Effects of Different Stabilizers on Miniemulsion Methyl Methacrylate Polymerizations

In situ encapsulation of praziquantel through methyl methacrylate/diethylaminoethyl methacrylate and MMA/DMAEMA miniemulsion copolymerizations in presence of distinct ionic surfactants

P(MMA‐co‐AA) Nanoparticles Loaded with Clioquinol and Functionalized with TAT Peptide

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