Background and Aim: Ice cream is a sweetened frozen food typically eaten as a snack or dessert. It is usually made from dairy products such as milk (usually cow milk). Recently, health-conscious individuals do not often consume ice cream because they are lactose intolerant. Hence, analogs made from goat's or sheep's milk, or milk substitutes (e.g., soy milk, tiger nut milk and so on) may serve as alternatives to cow milk (partially or fully substituted) in the production of ice cream. The aim of this study was production, quality evaluation and acceptability of ice cream from the blends of cow milk, tiger nut, and African yam bean seed milk. Methods: The collected tiger nuts and African yam bean seed was processed into flours before the extraction of milk from the flours. Cow milk, tiger nut milk, and African yam bean milk were formulated in different proportions of 100: