Production and Drug Release Assesment of Melatonin Loaded Alginate/Gum Arabic Beads

Girgin, Bernis; Korkmaz, Onur; Yavaşer, Rukiye; Karagözler, Arife Alev

doi:10.18596/jotcsa.30880

Cited by 4 publications

(3 citation statements)

References 14 publications

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“…Most trials on hydrogels for the treatment of cancer have investigated the injection of hydrogels into mice [ 22 , 23 , 24 ]. A series of injectable and cross-linked hydrogels using biocompatible and carbohydrate-based polymers such as quaternized chitosan, hyaluronic acid, fucoidan, and poly-ethylene glycol have been developed as nanocarriers for the delivery of therapeutic agents [ 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ]. However, hydrogels remain in the injection site for a certain period of time, which may promote inflammation and other side effects [ 33 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

Attachable Hydrogel Containing Indocyanine Green for Selective Photothermal Therapy against Melanoma

Hwang

2020

Biomolecules

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Melanoma is the most lethal form of skin cancer because it spreads easily to other tissues, thereby decreasing the efficiency of its treatment via chemo-, radio-, and surgical therapies. We suggest the application of an attachable hydrogel for the treatment of melanoma whereby the size and amount of incorporated indocyanine green (ICG) for photothermal therapy (PTT) can be controlled. An attachable hydrogel (poly(acrylamide-co-diallyldimethylammonium chloride); PAD) that incorporates ICG as a near-infrared (NIR) absorber was fabricated using a biocompatible polymer. The temperature of PAD-ICG increases under 808 nm laser irradiation. The hydrogel protects the ICG against decomposition; consequently, PAD-ICG can be reused for PTT. The attachment of PAD-ICG to an area with melanoma in mice, with irradiation using a NIR laser, successfully eliminated melanoma. Thus, the data suggest that PAD-ICG is a smart material that could be used for selective target therapy against melanoma in humans.

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Section: Introductionmentioning

confidence: 99%

Attachable Hydrogel Containing Indocyanine Green for Selective Photothermal Therapy against Melanoma

Hwang

2020

Biomolecules

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“…We have been interested in the development of dosage form products, which mimic the physiologically secreted high MLT levels at night, necessary to promote sleep onset and maintain sleep (12). Sleep dysfunctions, referring to sleep onset difficulties, are better treated with fast release MLT products, whilst those related to sleep maintenance problems are preferably treated with MLT modified release formulations (13)(14)(15)(16)(17)(18)(19)(20)(21). In this report we communicate our findings on the in vitro release of MLT from calcium alginate (CA) hydrogel beads, containing combinations of polyvinylpyrrolidone (PVP 10000 and PVP 55000 ), hydroxypropylmethylcellulose (HPMC 15000 and HPMC 100000 ), lactose monohydrate and as a surfactant sodium lauryl sulfate (SLS).…”

mentioning

confidence: 99%

“…Furthermore, polymeric beads show high bioavailability and stability. Other advantages include limited fluctuation in the therapeutic range, reduced side effects, decreased dosing frequency and improved patient compliance (21,22). Moreover, the swelling behavior in conditions, like those of gastrointestinal liquids, is a very important parameter that has to be investigated during the development of these systems for the oral administration of drugs (23).…”

mentioning

confidence: 99%

Probing the release of the chronobiotic hormone melatonin from hybrid calcium alginate hydrogel beads

et al. 2020

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A variety of commonly used hydrogels were utilized in the preparation of calcium alginate beads, which incorporate the chronobiotic hormone melatonin (MLT). The in vitro release of the hormone in aqueous media at pH 1.2 and 6.8 was probed in the conjunction with the swelling of the beads and their thermal degradation properties. It has been found that the release of MLT from the beads was reversibly proportional to the extent of their expansion, which depends on the molecular mass/viscosity of the biopolymers present in the beads; the higher the molecular mass/viscosity of the hydrogels the greater the beads swelling and the less the MLT’s release. Thermogravimetric analysis (TGA) data support the presence of the components in the hybrid hydrogel beads and elucidate their effects on the thermal stability of the systems. Thus, the physicochemical properties of the biopolymers used, along with their stereoelectronic features modulate the release of MLT from the beads, providing formulations able to treat sleep onset related problems or dysfunctions arising from poor sleep maintenance.

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Synthesis of Cyclodextrin-Based Multifunctional Biocompatible Hydrogels and Their Use in the Prevention of Intrauterine Adhesions (Asherman’s Syndrome) after Surgical Injury

Aksoy Erden,

Kurus,

Turkcuoglu

et al. 2024

ACS Omega

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Asherman's syndrome, which can occur during the regeneration of damaged uterine tissue after surgical interventions, is a significant health problem in women. This study aimed to acquire and characterize cyclodextrin-based hydrogels, which can be used to prevent Asherman's syndrome, and investigate their effectiveness with biomedical applications. A series of hydrogels were synthesized from the crosslinking of β-cyclodextrin and different polyphenols with epoxy-functional PEG. Their chemical, physical, and biological properties were subsequently determined. The results demonstrated that the cyclodextrin-based hydrogels had a porous structure, high swelling ratio, good injectability, drug release ability, and antioxidant activity. Cell culture results illustrated that the hydrogels had no significant cytotoxicity toward L929 fibroblast cells. Considering all properties, the β-CD-PEG-600-Ec hydrogel showed the most satisfactory properties rather than other ones. The potential of this hydrogel in preventing Asherman's syndrome was evaluated in a rat model. The results revealed that the βestradiol-and melatonin-loaded cyclodextrin-based multifunctional hydrogel group both structurally and mechanically showed an antiadhesion effect in the uterus and a therapeutic effect on the damage with the β-estradiol and melatonin that it contains compared to the Asherman (ASH) group. This double drug-loaded hydrogel can be a promising candidate for preventing Asherman's syndrome due to its versatile properties.

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Production and Drug Release Assesment of Melatonin Loaded Alginate/Gum Arabic Beads

Cited by 4 publications

References 14 publications

Attachable Hydrogel Containing Indocyanine Green for Selective Photothermal Therapy against Melanoma

Attachable Hydrogel Containing Indocyanine Green for Selective Photothermal Therapy against Melanoma

Probing the release of the chronobiotic hormone melatonin from hybrid calcium alginate hydrogel beads

Synthesis of Cyclodextrin-Based Multifunctional Biocompatible Hydrogels and Their Use in the Prevention of Intrauterine Adhesions (Asherman’s Syndrome) after Surgical Injury

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