Production and Distribution of Intracranial and Intraspinal Pressure Changes at Sudden Extradural Fluid Volume Input in Rabbits

Lindgren, S.; Kinder, Lennart

doi:10.1111/j.1748-1716.1969.tb04477.x

Cited by 56 publications

(10 citation statements)

References 12 publications

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“…The invasive method used by Wåhlin et al measures the pulse pressure in the spinal canal and the same value is assumed in the cranium. This assumption contrasts reports documenting higher pulse pressure in the cranium (24, 25). The lumped‐parameter model used in our approach allows to estimation of the pulse pressure in each compartment individually.…”

Section: Discussioncontrasting

confidence: 97%

Determination of cranio‐spinal canal compliance distribution by MRI: Methodology and early application in idiopathic intracranial hypertension

Tain

Bagci

Lam

et al. 2011

Magnetic Resonance Imaging

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PURPOSE To develop a method for derivation of the cranial-spinal compliance distribution, assess its reliability, and apply to obese female patients with a diagnosis of Idiopathic Intracranial Hypertension (IIH). MATERIALS AND METHODS Phase contrast based measurements of blood and CSF flows to, from, and between the cranial and spinal canal compartments were used with lumped-parameter modeling to estimate systolic volume and pressure changes from which cranial and spinal compliance indices are obtained. The proposed MRI indices are analogous to pressure volume indices (PVI) currently being measured invasively with infusion based techniques. The consistency of the proposed method was assessed using MRI data from 7 aged healthy subjects. Measurement reproducibility was assessed using 5 repeated MR scans from one subject. The method was then applied to compare spinal canal compliance contribution in 7 IIH patients and 6 matched healthy controls. RESULTS In the healthy subjects, as expected, spinal canal contribution was consistently larger than the cranial contribution (average value of 69%). Measurement variability was 8%. In IIH, the spinal canal contribution is significantly smaller than normal controls (60 vs. 78%, P<0.03). CONCLUSION MRI based method for derivation of compliance indices analogous to PVI has been implemented and applied to healthy subjects. The application of the method to obese IIH patients points to the potential role of the spinal canal compartment in IIH.

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Section: Discussioncontrasting

confidence: 97%

Determination of cranio‐spinal canal compliance distribution by MRI: Methodology and early application in idiopathic intracranial hypertension

Tain

Bagci

Lam

et al. 2011

Magnetic Resonance Imaging

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“…In the late 1960s at the University of Göteborg, Lindgren and Rinder 35–37 developed a mechanical ‘percussion concussion’ brain-injury model in rabbits based on hydraulically induced pressure transients. In mid-1970s at the Medical College of Virginia, Sullivan et al 38 used a similar brain injury model in cats.…”

Section: Introductionmentioning

confidence: 99%

Fluid-percussion–induced traumatic brain injury model in rats

et al. 2010

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Traumatic brain injury (TBI) is a major cause of mortality and morbidity. Various attempts have been made to replicate clinical TBI using animal models. The fluid-percussion model (FP) is one of the oldest and most commonly used models of experimentally induced TBI. Both central (CFP) and lateral (LFP) variations of the model have been used. Developed initially for use in larger species, the standard FP device was adapted more than 20 years ago to induce consistent degrees of brain injury in rodents. Recently, we developed a microprocessor-controlled, pneumatically driven instrument, micro-FP (MFP), to address operational concerns associated with the use of the standard FP device in rodents. We have characterized the MFP model with regard to injury severity according to behavioral and histological outcomes. In this protocol, we review the FP models and detail surgical procedures for LFP. The surgery involves tracheal intubation, craniotomy and fixation of Luer fittings, and induction of injury. The surgical procedure can be performed within 45–50 min.

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“…Lindgren & Rinder 1969). However, the subatmospheric pressure produced at the surface ofthe moving plunger is difficult to transmit to the skull cavity, maximum amplitude below -0.5 atm was not obtained.…”

Section: Discussionmentioning

confidence: 94%

EXPERIMENTAL BRAIN DAMAGE FROM FLUID PRESSURES DUE TO IMPACT ACCELERATION. 1. Design of Experimental Procedure

Stålhammar

2009

Acta Neurologica Scandinavica

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The significance of the intracranial acceleration prcssure pattern at impact to the intact skull in production of brain damage is discussed particularly as regards the contre-coup pressures. Sudden pressure changes within the cranial cavity of the rabbit were studied by means of a new impact acceleration model. The rabbit skull was connected with a cylinder. Impact acceleration was applied to the model with the skull contents serving as a "contre-coup end". Skull deformation was minimized by reinforcement of the skull vault. Acceleration, velocity and displacement of the system were recorded at various sites and could be predicted within wide ranges. Simultaneous recordings were also made of the pressure changes in the skull cavity and cylinder contents. By adjusting the acceleration course and by introducing a quantified air bubble (50, 100, 150 mm3) at the impact of the cylinder, it was possible to produce and vary an intracranial pressure pattern of "contre-coup type", including predietahle subatmospheric transients. The mechanics of the intracranial pressure changes and displacements are discussed. The method sccms to be suitable for studying the relations between brief negative-positive pressure variations (about 5 ms) of "contre-coup type" and pathological alterations similar to those reported in other head injury models and in human head trauma.

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Production and Distribution of Intracranial and Intraspinal Pressure Changes at Sudden Extradural Fluid Volume Input in Rabbits

Cited by 56 publications

References 12 publications

Determination of cranio‐spinal canal compliance distribution by MRI: Methodology and early application in idiopathic intracranial hypertension

Determination of cranio‐spinal canal compliance distribution by MRI: Methodology and early application in idiopathic intracranial hypertension

Fluid-percussion–induced traumatic brain injury model in rats

EXPERIMENTAL BRAIN DAMAGE FROM FLUID PRESSURES DUE TO IMPACT ACCELERATION. 1. Design of Experimental Procedure

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