Production and Application of Lactic Acid

Rodrigues, Cristine; Vandenberghe, Luciana Porto de Souza; Woiciechowski, Adenise Lorenci; Oliveira, Juliana de; Letti, Luiz Alberto Júnior; Soccol, Carlos Ricardo

doi:10.1016/b978-0-444-63662-1.00024-5

Cited by 43 publications

(42 citation statements)

References 59 publications

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“…In general, pretreatment of the cell-free fermentation broth by acidification using H 2 SO 4 is necessary for lactate recovery by the typical ion exchange resinbased process. Furthermore, using the typical ion exchanger to separate lactic acid from the fermentation broth requires 3 main steps including feed stream loading (adsorption), washing (to remove unbound solution from the resins), and lactic acid elution by proper eluant (desorption) [8]. This resulted in the increasing consumption of chemicals, wastewater treatment, and eventually dilution of the fermentation broth after acidification.…”

Section: Water Permeability and Solute Rejection At The Swro Unitmentioning

confidence: 99%

“…The first step in primary recovery units involves cell separation by centrifugation or microfiltration [4][5][6][7]. Several downstream techniques have been used for recovering and separating lactic acid, including reactive distillation, reactive extraction, adsorption (ion exchange), and membrane separation (electrodialysis) [8]. Both distillation and electrodialysis have high energy consumption in a large-scale operation because of the low volatility of lactic acid and high electricity loading, respectively [9].…”

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confidence: 99%

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Alternative reverse osmosis to purify lactic acid from a fermentation broth

Phanthumchinda

Rampai

Prasirtsak

et al. 2018

CI&CEQ

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Brackish water reverse osmosis (BWRO) and seawater reverse osmosis (SWRO) membranes were used in a two-stage reverse osmosis (RO) unit to recover, pre-purify, and pre-concentrate lactic acid. Calcium lactate, sodium lactate, and ammonium lactate were used as model feed solutions. The operating pressure showed a pronounced effect on lactate passage through the first BWRO unit, and the Donnan exclusion effect and hydrogen bonding were responsible for cation rejection. Calcium ions were rejected at the BWRO unit because of low diffusion rate and charge interaction at the surface. However, monovalent ions formed hydrogen bonds with the carbonyl group of the membrane that allowed passage across the membrane. The second SWRO unit was for pre-concentrating lactic acid. A high lactate purity of 99.2% with a total recovery of 50.5% was acquired from calcium lactate feed solution. Lower purity with higher lactate recovery was obtained when the feed solution was sodium lactate and ammonium lactate. When the actual fermentation broth was used in the two-stage RO unit, a slightly lower recovery and purity of lactic acid were obtained. It was claimed that the total ions present in the fermentation broth were responsible for the low efficiency of the two-stage RO unit.

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Section: Water Permeability and Solute Rejection At The Swro Unitmentioning

confidence: 99%

mentioning

confidence: 99%

Alternative reverse osmosis to purify lactic acid from a fermentation broth

Phanthumchinda

Rampai

Prasirtsak

et al. 2018

CI&CEQ

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“…Fungi is extensively used in the production of industrial enzymes, secondary metabolites, and fermented foods . Lactic acid bacteria have been proposed and proven for their production of lactic acid, which is a potential building block for biodegradable plastics …”

Section: Culture Collection As Microbial Sources For Biorefinerymentioning

confidence: 99%

Bioenergy and Biorefinery: Feedstock, Biotechnological Conversion, and Products

Amoah

Kahar

Kondo

2019

Biotechnology Journal

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Biorefinery has been suggested to provide relevant substitutes to a number of fossil products. Feedstocks and conversion technologies have, however, been the bottleneck to the realization of this concept. Herein, feedstocks and bioconversion technologies under biorefinery have been reviewed. Over the last decade, research has shown possibilities of generating tens of new products but only few industrial implementations. This is partly associated with low production yields and poor cost-competitiveness. This review addresses the technical barriers associated with the conversion of emerging feedstocks into chemicals and bioenergy platforms and summarizes the developed biotechnological approaches including advances in metabolic engineering. This summary further suggests possible future advances that would expand the portfolio of biorefinery and speed up the realization of biofuels and biochemicals.

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“…Lactic acid (LA) is an organic acid which can be produced by lactic acid bacteria for many purposes, starting from food preservatives and finishing at medicines [1]. The increasing demand for poly-lactic acid (PLA), a biodegradable plastic, has also boosted lactic acid's market [2].…”

Section: Introductionmentioning

confidence: 99%

Production and Purification of l-lactic Acid in Lab and Pilot Scales Using Sweet Sorghum Juice

et al. 2019

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Sweet sorghum juice (SSJ) was evaluated as fermentation substrate for the production of l-lactic acid. A thermophilic Bacillus coagulans isolate was selected for batch fermentations without the use of additional nutrients. The first batch of SSJ (Batch A) resulted on higher lactic acid concentration, yield and productivity with values of 78.75 g∙L−1, 0.78 g∙g−1 and 1.77 g∙L−1 h−1, respectively. Similar results were obtained when the process was transferred into the pilot scale (50 L), with corresponding values of 73 g∙L−1, 0.70 g∙g−1 and 1.47 g∙L−1 h−1. A complete downstream process scheme was developed in order to separate lactic acid from the fermentation components. Coarse and ultra-filtration were employed as preliminary separation steps. Mono- and bipolar electrodialysis, followed by chromatography and vacuum evaporation were subsequently carried out leading to a solution containing 905.8 g∙L−1 lactic acid, with an optical purity of 98.9%. The results of this study highlight the importance of the downstream process with respect to using SSJ for lactic acid production. The proposed downstream process constitutes a more environmentally benign approach to conventional precipitation methods.

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Production and Application of Lactic Acid

Cited by 43 publications

References 59 publications

Alternative reverse osmosis to purify lactic acid from a fermentation broth

Alternative reverse osmosis to purify lactic acid from a fermentation broth

Bioenergy and Biorefinery: Feedstock, Biotechnological Conversion, and Products

Production and Purification of l-lactic Acid in Lab and Pilot Scales Using Sweet Sorghum Juice

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