Product indiscriminate use of vitamin risks: A review

Mello, Acsa Lima Marinho Fonseca de; Melo, Karolynne Rodrigues de; Sousa, Aretuza; Neto, Pedró José Rolim; Silva, Rosali Maria Ferreira da

doi:10.1080/10408398.2019.1628003

Cited by 8 publications

(7 citation statements)

References 67 publications

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“…So far, several databases have been constructed to provide DDI-relevant information, which have become popular data resources for current pharmaceutical studies. − Some of them contain DDI information as part of a broader collection of biological and pharmacological data (such as DrugBank, TTD, SuperDRUG2, Transformer, and SuperCYPsPred), and some others focus on providing the clinical phenomena and outcomes of DDIs (such as DDInter, Drugs.com, and Liverpool drug interaction). Particularly, DDInter, the newly-constructed DDI database, provides a wealth of DDI information.…”

Section: Introductionmentioning

confidence: 99%

“…Particularly, DDInter, the newly-constructed DDI database, provides a wealth of DDI information. These databases have attracted broad interest from the research community and accumulated a huge number of visits and citations in the past few years. − However, none of the databases provides explicit clarifications on the molecular mechanism underlying a comprehensive list of existing DDIs (both PK and PD).…”

Section: Introductionmentioning

confidence: 99%

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MecDDI: Clarified Drug–Drug Interaction Mechanism Facilitating Rational Drug Use and Potential Drug–Drug Interaction Prediction

Zhang

Zhou

et al. 2023

J. Chem. Inf. Model.

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Drug–drug interactions (DDIs) are a major concern in clinical practice and have been recognized as one of the key threats to public health. To address such a critical threat, many studies have been conducted to clarify the mechanism underlying each DDI, based on which alternative therapeutic strategies are successfully proposed. Moreover, artificial intelligence-based models for predicting DDIs, especially multilabel classification models, are highly dependent on a reliable DDI data set with clear mechanistic information. These successes highlight the imminent necessity to have a platform providing mechanistic clarifications for a large number of existing DDIs. However, no such platform is available yet. In this study, a platform entitled “MecDDI” was therefore introduced to systematically clarify the mechanisms underlying the existing DDIs. This platform is unique in (a) clarifying the mechanisms underlying over 1,78,000 DDIs by explicit descriptions and graphic illustrations and (b) providing a systematic classification for all collected DDIs based on the clarified mechanisms. Due to the long-lasting threats of DDIs to public health, MecDDI could offer medical scientists a clear clarification of DDI mechanisms, support healthcare professionals to identify alternative therapeutics, and prepare data for algorithm scientists to predict new DDIs. MecDDI is now expected as an indispensable complement to the available pharmaceutical platforms and is freely accessible at: .

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

MecDDI: Clarified Drug–Drug Interaction Mechanism Facilitating Rational Drug Use and Potential Drug–Drug Interaction Prediction

Zhang

Zhou

et al. 2023

J. Chem. Inf. Model.

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“…The interaction potential of vitamins, minerals, or animal-originated products (such as glucosamine) is not part of this article. An overview can be found in [ 15 , 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Herb–Drug Interaction in Inflammatory Diseases: Review of Phytomedicine and Herbal Supplements

Lippert

Renner

2022

JCM

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Many people worldwide use plant preparations for medicinal purposes. Even in industrialized regions, such as Europe, where conventional therapies are accessible for the majority of patients, there is a growing interest in and usage of phytomedicine. Plant preparations are not only used as alternative treatment, but also combined with conventional drugs. These combinations deserve careful contemplation, as the complex mixtures of bioactive substances in plants show a potential for interactions. Induction of CYP enzymes and pGP by St John’s wort may be the most famous example, but there is much more to consider. In this review, we shed light on what is known about the interactions between botanicals and drugs, in order to make practitioners aware of potential drug-related problems. The main focus of the article is the treatment of inflammatory diseases, accompanied by plant preparations used in Europe. Several of the drugs we discuss here, as basal medication in chronic inflammatory diseases (e.g., methotrexate, janus kinase inhibitors), are also used as oral tumor therapeutics.

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“…Vinculado a esse fator, encontra-se a praticidade da suplementação e a tendência da autossuplementação, muitas vezessem mensurar os riscos reaisintrínsecos (MELLO et al, 2019). (ARMITAGE, 2010;HANKEY et al, 2010;JENKINS et al, 2018;KRISTINE;PEDERSEN, 2008;VAN DIJK et al,2015).Contudo, grande partedos multivitamínicos,popularmente comercializados,não apresenta eficácia asseguradapara a saúde, pois existem baixos oumoderados níveis de evidênciaspara benefícios preventivos.…”

Section: Introductionunclassified

“…Suplementos são vendidos livremente, sem a necessidade de prescrição ou acompanhamento de um profissional da saúde qualificado. Estudos apontam para o alto consumo de suplementos em condições que não se verifica a real necessidade da suplementação e,na ausência de acompanhamento com exames laboratoriais, o uso irracional pode resultar em eventos adversos, comdanosirreversíveis, mesmo que evitáveis (MELLO et al, 2019). Outro fator preocupantenesta perspectiva, é a existência produtos adulterados e, até mesmo, falsificados(SI VA; SILVA, 2019).…”

Section: Introductionunclassified

Um Novo Método Para Quantificação Simultânea De Vitaminas B6 E B12 Por Clae

Alves¹,

Rosa²,

Weimer³

et al. 2020

Farmácia E Promoção Da Saúde 4

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Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição 4.0 Internacional (CC BY 4.0).O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais.

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Product indiscriminate use of vitamin risks: A review

Cited by 8 publications

References 67 publications

MecDDI: Clarified Drug–Drug Interaction Mechanism Facilitating Rational Drug Use and Potential Drug–Drug Interaction Prediction

MecDDI: Clarified Drug–Drug Interaction Mechanism Facilitating Rational Drug Use and Potential Drug–Drug Interaction Prediction

Herb–Drug Interaction in Inflammatory Diseases: Review of Phytomedicine and Herbal Supplements

Um Novo Método Para Quantificação Simultânea De Vitaminas B6 E B12 Por Clae

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