Producing fucoxanthin from algae – Recent advances in cultivation strategies and downstream processing

Leong, Yoong Kit; Chen, Chun‐Yen; Varjani, Sunita; Chang, Jo‐Shu

doi:10.1016/j.biortech.2021.126170

Cited by 53 publications

(47 citation statements)

References 97 publications

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“…Carotenoids are high-value pigments produced by photosynthetic organisms with several benefits in terms of health and nutrition. These molecules are important antioxidants, and their applications range from animal feed to human food and dietary supplements, cosmetics and pharmaceuticals [ 1 , 2 , 3 ]. The global carotenoid market is expected to have a steady increase of 5% during the next decade, with carotenoid sales likely to be over 2 billion US Dollars by 2031 [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…P. tricornutum is a promising source of fucoxanthin, since it contains at least ten times more fucoxanthin per gram of dry weight than brown algae [ 2 ], but the optimisation of yields needs to be further achieved. The capacity of these microalgae to grow under mixotrophic cultivation, i.e., combining photoautotrophic and heterotrophic growth, increases the flexibility in cultivation conditions and leads to higher biomass concentrations compared with photoautotrophic conditions [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

“…Regarding the optimisation of media composition for fucoxanthin production, most studies have focused on variations in the nitrogen source and its concentration [ 25 , 26 , 30 , 31 ]. Nitrogen is a key nutrient for microalgae growth and is involved in the regulation of the synthesis of cellular metabolites such as fucoxanthin and lipids [ 2 ]; thus, the modulation of this macronutrient can lead to enhanced growth and pigment content. Several nitrogen sources have been tested, including nitrate, ammonium chloride, urea and ammonium sulphate [ 30 , 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

“…Several nitrogen sources have been tested, including nitrate, ammonium chloride, urea and ammonium sulphate [ 30 , 32 , 33 ]. Nitrate is considered the most efficient nitrogen source since it leads to a high growth rate and increased fucoxanthin production [ 2 ] and is stable during autoclaving, facilitating media preparation in the laboratory [ 34 ]. Nitrogen media supplementation was found to further increase fucoxanthin productivity [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

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Optimal Nitrate Supplementation in Phaeodactylum tricornutum Culture Medium Increases Biomass and Fucoxanthin Production

Afonso

Bragança

Rebelo

et al. 2022

Foods

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Phaeodactylum tricornutum is a model diatom with numerous potential applications in the industry, including the production of high-value carotenoid pigments such as fucoxanthin. This compound is a potent antioxidant currently extracted mainly from brown macroalgae. Fucoxanthin exhibits several biological properties with well-known beneficial effects in the treatment and prevention of lifestyle-related diseases. P. tricornutum offers a valuable alternative to macroalgae for fucoxanthin production as it has a specific productivity that is 10-fold higher as compared with macroalgae. However, production processes still need to be optimised to become a cost-effective alternative. In this work, we investigated the optimal supplementation of nitrate in a cultivation medium that is currently used for P. tricornutum and how this nitrate concentration affects cell growth and fucoxanthin production. It has previously been shown that the addition of sodium nitrate increases productivity, but optimal conditions were not accurately determined. In this report, we observed that the continuous increase in nitrate concentration did not lead to an increase in biomass and fucoxanthin content, but there was rather a window of optimal values of nitrate that led to maximum growth and pigment production. These results are discussed considering both the scale up for industrial production and the profitability of the process, as well as the implications in the cell’s metabolism and effects in fucoxanthin production.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Optimal Nitrate Supplementation in Phaeodactylum tricornutum Culture Medium Increases Biomass and Fucoxanthin Production

Afonso

Bragança

Rebelo

et al. 2022

Foods

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show abstract

“…Fucoxanthin is a natural carotenoid that occupies nearly 10% of total natural carotenoid production [62]. The global production of fucoxanthin was about 500 tons in 2016 and was estimated to increase further with an annual rate of 5.3% [63]. As shown in Figure 2, it has a unique molecular structure with an allenic bond, a conjugated carbonyl, a 5,6-monoepoxide and acetyl groups.…”

Section: Fucoxanthinmentioning

confidence: 99%

Carotenoid Production from Microalgae: Biosynthesis, Salinity Responses and Novel Biotechnologies

et al. 2021

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Microalgae are excellent biological factories for high-value products and contain biofunctional carotenoids. Carotenoids are a group of natural pigments with high value in social production and human health. They have been widely used in food additives, pharmaceutics and cosmetics. Astaxanthin, β-carotene and lutein are currently the three carotenoids with the largest market share. Meanwhile, other less studied pigments, such as fucoxanthin and zeaxanthin, also exist in microalgae and have great biofunctional potentials. Since carotenoid accumulation is related to environments and cultivation of microalgae in seawater is a difficult biotechnological problem, the contributions of salt stress on carotenoid accumulation in microalgae need to be revealed for large-scale production. This review comprehensively summarizes the carotenoid biosynthesis and salinity responses of microalgae. Applications of salt stress to induce carotenoid accumulation, potentials of the Internet of Things in microalgae cultivation and future aspects for seawater cultivation are also discussed. As the global market share of carotenoids is still ascending, large-scale, economical and intelligent biotechnologies for carotenoid production play vital roles in the future microalgal economy.

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Modern Approach Toward Algal‐Based Natural Pigments for Textiles

Salman,

Adeel,

Naseer

et al. 2024

Plant Biomass Derived Materials

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Producing fucoxanthin from algae – Recent advances in cultivation strategies and downstream processing

Cited by 53 publications

References 97 publications

Optimal Nitrate Supplementation in Phaeodactylum tricornutum Culture Medium Increases Biomass and Fucoxanthin Production

Optimal Nitrate Supplementation in Phaeodactylum tricornutum Culture Medium Increases Biomass and Fucoxanthin Production

Carotenoid Production from Microalgae: Biosynthesis, Salinity Responses and Novel Biotechnologies

Modern Approach Toward Algal‐Based Natural Pigments for Textiles

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