Producing Capabilities of Interferon-gamma and Interleukin-10 in Peripheral Blood from Oral Squamous Cell Carcinoma Patients

Abstract

In order to evaluate the Th1 and Th2 responses of Oral Squamous Cell Carcinoma (OSCC) patients, we investigated the cytokine producing capability of peripheral blood (PB), and compared it with clinicopathological appearances of OSCC patients. The production of a Th1-type cytokine, interferon (IFN)-γ, from lipopolysaccharide (LPS)-stimulated PB correlated positively with the frequency of lymph node metastasis. We also investigated the production of a Th2-type cytokine, IL-10, however, no significant correlation was observed with the clinicopathological appearances. Our results suggested that the IFN-γ producing capability was specifically regulated and dependent on the regional metastatic potencies of OSCCs.

Subsite-specific association of DEAD box RNA helicase DDX60 with the development and prognosis of oral squamous cell carcinoma

“…DDX60 is a type I interferon-inducible gene in response to viral infections [ 12 ]. Conversely, DDX60 can induce type I IFN (IFN-α/β), which is a well-known potent cytokine under an antiviral innate immune response [ 27 ]. Surprisingly, type I IFN has been implicated in cancer development [ 28 , 29 ].…”

“…Moreover, the activation of inflammatory cytokines [ex. type I interferon (IFN-α/β), tumor necrosis factor-alpha (TNF-α), and type II interferon (IFN)-γ] in response to viral/chemical carcinogens is significantly associated with OSCC [ 27 , 29 , 48 ]. DDX60 could be induced by type I interferon, and the possibility that DDX60 could be induced by other inflammatory cytokines could not be excluded [ 12 , 14 ] and needs further verification.…”

Cytokine expression profiles in the sera of cutaneous squamous cell carcinoma patients

“…At present, several cytokines such as IFN-γ, IL-6, GM-CSF, and TGF-β have been reported to be involved in keratinocyte proliferation of the skin, and in the pathogenesis of SCC (2)(3)(4)(5)(6). In this study, we focused on the interaction of cytokines, and showed the expression profile of multiple cytokines in the serum of each patient with SCC.…”

Cytokine production in mammary adenocarcinoma and its microenvironmental cells in patients with or without metastases in regional lymph nodes

“… 1 – 4 It is known, for example, that cytokines can not only inhibit (interferon (IFN)-γ, tumour necrosis factor (TNF)-α) but also enhance (interleukin (IL)-1β, IL-6, IL-8, transforming growth factor (TGF)-β, monocyte chemoattractant protein-1 (MCP-1), colony-stimulating factor (CSF)-1 and vascular endothelial growth factor (VEGF)) the growth and metastasis of a malignant tumour including breast cancer. 1 , 2 , 5 – 7 There are correlations between the concentration of certain cytokines in blood (IFN-γ, IL-10 and VEGF) and the degree of tumour vascularisation, tumour cell proliferation, tumour invasiveness and metastasis. 6 , 8 , 9 Nonetheless, there is little data on the extent to which the growth and metastasis of malignant tumours depends on the cytokines produced by immune system cells, how effectively these cytokines enter the tumour through its vascular network and to which degree endogenous (i.e.…”

“… 1 , 2 , 5 – 7 There are correlations between the concentration of certain cytokines in blood (IFN-γ, IL-10 and VEGF) and the degree of tumour vascularisation, tumour cell proliferation, tumour invasiveness and metastasis. 6 , 8 , 9 Nonetheless, there is little data on the extent to which the growth and metastasis of malignant tumours depends on the cytokines produced by immune system cells, how effectively these cytokines enter the tumour through its vascular network and to which degree endogenous (i.e. intratumoral) cytokine production is not sufficient for tumour growth.…”