Abstract:The macrolide (+)-discodermolide produced by the marine sponge Discodermia dissoluta shows promising antitumor, antimitotic, and immunosuppressive activity. However, the sustainable supply of any molecule requires much in situ and in vitro research to optimize and later obtain the molecule of interest. In this study, two culture systems—fixed and suspended—were evaluated at 15-m depth in two sites, Punta de Betín and Nenguange, in Santa Marta (Colombian Caribbean). Survival, growth, and production of (+)-disco… Show more
“…Production of this important bioactive compound ranged from 20-270 mg g À1 of dry sponge. 520 In a similar vein, comparison of production of polycyclic guanidine compounds in wild and farmed Crambe crambe in the north western Mediterranean Sea found no difference between the populations, nor did other abiotic factors seem to inuence metabolite levels. Conversely, seasonal effects were apparent.…”
“…Production of this important bioactive compound ranged from 20-270 mg g À1 of dry sponge. 520 In a similar vein, comparison of production of polycyclic guanidine compounds in wild and farmed Crambe crambe in the north western Mediterranean Sea found no difference between the populations, nor did other abiotic factors seem to inuence metabolite levels. Conversely, seasonal effects were apparent.…”
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