Produção de micro e nanopartículas utilizando fluidos supercríticos

Bevilaqua, Gabriela; Rosa, Paulo de Tarso Vieira e

doi:10.14195/978-989-26-0881-5_10

Cited by 1 publication

(2 citation statements)

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“…The variation of solvent and anti-solvent flow rate is essential for precipitation. Combining these two process variables can produce many types of morphologies and different sizes of particles [17,38]. The CO2 flow rates evaluated in the present work are much lower than those considered in the experimental work reported in the literature described above.…”

Section: Co2 Flow Rate Influencementioning

confidence: 81%

“…Consequently, it increases its bioavailability, reduces the dose of medicine ingested, reduces the side effects, and minimizes the costs. The flow rates interfere with the jet-breaking regime and nucleation kinetics [38]. For example, in experimental literature work, with even higher CO2 flow rates, 20-130 l/ml, at p = 120 bar and T = 313 K, c0 = 5 g/l and constant flow rate of the solution of 1.5 ml/min, the size of particles precipitated in the SAS process decreases with increasing CO2 flow rate.…”

Section: Co2 Flow Rate Influencementioning

confidence: 99%

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Non-Isothermal Compressible Flow Model for Analyzing the Effect of High CO2 Inlet Flow Rate on Particle Size in a Supercritical Antisolvent Process

Almeida¹,

Rezende²,

Cardoso³

et al. 2023

J Energ Power Technol

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In this work with CFD simulations, the evaluation of the supercritical anti-solvent (SAS) process for producing nanoparticles from an expanded solution of ethanol/solute in carbon dioxide is reported. The influence of the solution and antisolvent flow rates on mean particle size, the flow dynamic, and the supercritical mixture's jet velocity must be well established in the literature and analyzed. The high flow rate of the anti-solvent resulted in increased mean particle sizes for all studied cases. At the lowest flow rate of CO2 examined, an increase in the solvent flow rate [0.3-1.0] ml/min initially led to a decrease of 11.2% in the mean particle diameter (MPD); however, further increasing the solvent flow rate [1.0-2.0]ml/min was an increase of 33% in this parameter. At the highest CO2 flow rate, the behavior of MPS was the opposite; it had a rise de 13.5% in MPD with an increase in solvent flow rate; further increasing the flow rate of the solvent, there was a drop of 8.6% in MPD. Significant variations in the temperature lead to large fluctuations in the particle diameters. At last, the contact zones between CO2 and ethanol were delimited, favoring the understanding of the influence of the flow patterns generated by the variation of the flow rates in the mean particle diameters.

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Section: Co2 Flow Rate Influencementioning

confidence: 81%

Section: Co2 Flow Rate Influencementioning

confidence: 99%