Prodrugs of triterpenoids and their derivatives

Zhou, Meng; Zhang, Ronghong; Wang, Min; Xu, Guo‐Bo; Liao, Shang‐Gao

doi:10.1016/j.ejmech.2017.03.005

Cited by 93 publications

(43 citation statements)

References 146 publications

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“…Natural products is a large resource for finding novel structures for candidate drugs, and more than 40% of the marketed drugs are derived from the secondary metabolites in plant. Among them, the terpenoids are prominent secondary metabolites for discovering new candidate drugs with wide spectrum of activities, including hepatoprotective, antiviral, anti-bacterial, anti-inflammatory, and anti-tumor agents (James and Dubery, 2009;Zhou et al, 2017).…”

Section: Terpenoidsmentioning

confidence: 99%

Toona sinensis: a comprehensive review on its traditional usages, phytochemisty, pharmacology and toxicology

Peng

Liu

et al. 2019

Revista Brasileira de Farmacognosia

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a b s t r a c tToona sinensis (Juss.) M.Roem, Meliaceae, a deciduous plant native to eastern and southeastern Asia, is widely used in Traditional Chinese Medicine. This paper was aimed to summarize the current advances in traditional usage, phytochemistry, pharmacology and toxicology of T. sinensis. In this review, various types of data of T. sinensis are discussed in the corresponding parts of this paper, and perspectives for possible future studies of this plant are discussed. The main constituents of T. sinensis are terpenoids, phenylpropanoids and flavonoids, etc., and its pharmacological activities include anti-tumor effects, antioxidant activities, anti-diabetic effects and anti-inflammatory effects. Although a series of phytochemical and pharmacological researches of this plant have been conducted, the active constituents and action mechanism of these activities should be also further explored. Furthermore, the present review also indicates that T. sinensis has potentials to develop into drugs for treating various diseases with high efficacy and low toxicity, particularly in cancer, diabetes and inflammatory disorders. In conclusion, the paper provides a full-scale profile of the traditional usage, phytochemistry, pharmacology and toxicology of T. sinensis, and also provides potential therapeutic uses and drug development prospects of this plant.

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Section: Terpenoidsmentioning

confidence: 99%

Toona sinensis: a comprehensive review on its traditional usages, phytochemisty, pharmacology and toxicology

Peng

Liu

et al. 2019

Revista Brasileira de Farmacognosia

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“…Majority of plant secondary metabolites are untapped and are of particular interest in insecticide development (Isman, 2006;Miresmailli and Isman, 2014). The pharmacological activities of natural triterpenoids and their therapeutic potentials are well documented (Dzubak et al, 2005(Dzubak et al, , 2006a(Dzubak et al, , 2006bMahato et al, 1992;Shanmugam et al, 2012;Zhou et al, 2017). Triterpenes are part of the terpenoid family, an extensive group of natural products, which are abundant in the plant kingdom.…”

Section: Isolation and Identification Of Insect Antifeedant Compound mentioning

confidence: 99%

Isolation and Identification of Insect Antifeedant Compound from Ethanol Extract of Hemidesmus indicus Root

Pillai¹,

Guendouz²,

Benniou³

2020

IJARe

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Phytochemicals with insect antifeedant potential can be used as a safer alternative to harmful chemicals that are used as grain protectants. The insect antifeedant effect of the extracts and fractions of Hemidesmus indicus root were tested against the stored grain insect pest Corcyra cephalonica Stainton. Bioactivity-guided study of ethanol extract of Hemidesmus indicus root led to isolation and identification of a triterpenoid, Lupeol with insect antifeedant potential. Although Lupeol showed insect antifeedant potential the ethanol extract was found to be more effective as an antifeedant. This implies that the synergistic action of compounds present in the ethanol extract of H. indicus root is responsible for the higher antifeedant potential.

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“…[ 22 ]. Many original researches and reviews are present in literature on the relationship compound-activity [ 23 , 24 ] as well as chemical class and related bioactivity, i.e., alkaloids [ 25 , 26 ], saponins [ 27 ], terpenoids [ 28 ], polyphenols [ 29 , 30 ], etc.…”

Section: Study Approach About Botanicals and Their Main Plant Compmentioning

confidence: 99%

From Plant Compounds to Botanicals and Back: A Current Snapshot

et al. 2018

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This work aims at giving an updated picture of the strict interaction between main plant biologically active compounds and botanicals. The main features of the emerging class of dietary supplements, the botanicals, are highlighted. Focus is also on the definition of actual possibilities of study approach and research strategies. Examples of innovative directions are given: assessment of interaction of bioactive compounds, chemometrics and the new goal of biorefineries. Current models of existing databases, such as plant metabolic pathways, food composition, bioactive compounds, dietary supplements, and dietary markers, are described as usable tools for health research. The need for categorization of botanicals as well as for the implementation of specific and dedicated databases emerged, based on both analytical data and collected data taken from literature throughout a harmonized and standardized approach for the evaluation of an adequate dietary intake.

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Prodrugs of triterpenoids and their derivatives

Cited by 93 publications

References 146 publications

Toona sinensis: a comprehensive review on its traditional usages, phytochemisty, pharmacology and toxicology

Toona sinensis: a comprehensive review on its traditional usages, phytochemisty, pharmacology and toxicology

Isolation and Identification of Insect Antifeedant Compound from Ethanol Extract of Hemidesmus indicus Root

From Plant Compounds to Botanicals and Back: A Current Snapshot

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