Prodrugs forming multifunctional supramolecular hydrogels for dual cancer drug delivery

Ha, Wei; Yu, Jing; Song, Xinyue; Zhang, Zhijun; Liu, Ying‐Qian; Shi, Yan‐Ping

doi:10.1039/c3tb20956c

Cited by 42 publications

(80 citation statements)

References 66 publications

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“…6B, C and D show several examples of the PEG/α-CD inclusion complex together with hydrogen bonding, ionic or hydrophobic interactions to form supramolecular hydrogels with dual physical crosslinks. 105, 115, 116 Compared with PEG/α-CD alone, the dual physical crosslinks not only significantly reduce gelation time, but also control the release kinetics for either a single drug or multiple drugs. For example, the PEG/α-CD complex with either hydrogen-bonding or electrostatic interactions as additional crosslinks shows gelation within 30–40 min with a storage modulus (G′) approaching 1000 Pa (Fig.…”

Section: Host-guest Chemistry-based Hydrogelsmentioning

confidence: 99%

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Weak bond-based injectable and stimuli responsive hydrogels for biomedical applications

Ding

Wang

2017

J. Mater. Chem. B

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Here we define hydrogels crosslinked by weak bonds as physical hydrogels. They possess unique features including reversible bonding, shear thinning and stimuli-responsiveness. Unlike covalently crosslinked hydrogels, physical hydrogels do not require triggers to initiate chemical reactions for in situ gelation. The drug can be fully loaded in a pre-formed hydrogel for delivery with minimal cargo leakage during injection. These benefits make physical hydrogels useful as delivery vehicles for applications in biomedical engineering. This review focuses on recent advances of physical hydrogels crosslinked by weak bonds: hydrogen bonds, ionic interactions, host-guest chemistry, hydrophobic interactions, coordination bonds and π-π stacking interactions. Understanding the principles and the state of the art of gels with these dynamic bonds may give rise to breakthroughs in many biomedical research areas including drug delivery and tissue engineering.

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Section: Host-guest Chemistry-based Hydrogelsmentioning

confidence: 99%

“…116 The combined chemotherapy of CPT and 5-FU is known to have higher anticancer efficacy compared to individual use. This is realized by coupling mPEG-COOH with CPT to yield an amphiphilic mPEG-CPT prodrug that could self-assemble into prodrug micelles.…”

Section: Host-guest Chemistry-based Hydrogelsmentioning

confidence: 99%

Weak bond-based injectable and stimuli responsive hydrogels for biomedical applications

Ding

Wang

2017

J. Mater. Chem. B

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“…The supramolecular cyclodextrin-polymer systems, based on this property, have been extensively studied since the early 90s. The noncovalent binding of the cyclodextrin by the functionalized polymers leads to a sharp increase in the viscosity of their solutions and to formation of hydrogels, which exhibit biocompatibility, sensitive to the external stimuli and are of interest as the drug-delivery systems and as components of the engineered tissues [9,10,12].…”

Section: Introductionmentioning

confidence: 99%

Supramolecular systems based on amidoammonium and amidoaminocalix[4]resorcinarenes and polyacrylic acid

Morozova

Syakaev

Ermakova

et al. 2015

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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“…Another example is provided by the Shi Lab, who adopted a highly supramolecular approach (Fig. 9E) [173]. Conjugating a low molecular weight PEG chain to CPT, they then mixed a solution of this micelle-forming conjugate with α-cyclodextrin (α-CD), a cyclized glucose hexamer with a central hydrophobic cavity.…”

Section: Supramolecular Hydrogels Formed By Amphiphilic Prodrugsmentioning

confidence: 99%

“…The drug 5-fluorouracil (5-FU) could also be encapsulated within the gel, with the slow dethreading of the psuedorotaxane breaking down the gel and releasing 5-FU and PEG-CPT micelles, that then underwent hydrolysis to release CPT. Reprinted from ref [173], copyright 2013 Royal Society of Chemistry.…”

Section: Figurementioning

confidence: 99%

Building nanostructures with drugs

2016

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The convergence of nanoscience and drug delivery has prompted the formation of the field of nanomedicine, one that exploits the novel physicochemical and biological properties of nanostructures for improved medical treatments and reduced side effects. Until recently, this nanostructure-mediated strategy considered the drug to be solely a biologically active compound to be delivered, and its potential as a molecular building unit remained largely unexplored. A growing trend within nanomedicine has been the use of drug molecules to build well-defined nanostructures of various sizes and shapes. This strategy allows for the creation of self-delivering supramolecular nanomedicines containing a high and fixed drug content. Through rational design of the number and type of the drug incorporated, the resulting nanostructures can be tailored to assume various morphologies (e.g. nanospheres, rods, nanofibers, or nanotubes) for a particular mode of administration such as systemic, topical, and local delivery. This review covers the recent advances in this rapidly developing field, with the aim of providing an in-depth evaluation of the exciting opportunities that this new field could create to improve the current clinical practice of nanomedicine.

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Prodrugs forming multifunctional supramolecular hydrogels for dual cancer drug delivery

Cited by 42 publications

References 66 publications

Weak bond-based injectable and stimuli responsive hydrogels for biomedical applications

Weak bond-based injectable and stimuli responsive hydrogels for biomedical applications

Supramolecular systems based on amidoammonium and amidoaminocalix[4]resorcinarenes and polyacrylic acid

Building nanostructures with drugs

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