2024
DOI: 10.1002/adhm.202401936
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Prodrug Nanomedicine for Synovium Targeted Therapy of Inflammatory Arthritis: Insights from Animal Model and Human Synovial Joint Fluid

Zeynab Nosrati,
Yun An Chen,
Marta Bergamo
et al.

Abstract: Many patients cannot tolerate low‐dose weekly methotrexate (MTX) therapy for inflammatory arthritis treatment due to life‐threatening toxicity. Although biologics offer a target‐specific therapy, it raises the risk of serious infections and even cancer due to immune system suppression. We introduce an anti‐inflammatory arthritis MTX ester prodrug using a long‐circulating biocompatible polymeric macromolecule: folic acid (FA) functionalized hyperbranched polyglycerol (HPG). In vitro the drug MTX is incrementall… Show more

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