Prodrug-loaded semiconducting polymer hydrogels for deep-tissue sono-immunotherapy of orthotopic glioblastoma

Zhu, Li; Wang, Xing; Ding, Mengbin; Yu, Ningyue; Zhang, Yijing; Wu, Huifeng; Zhang, Qin; Liu, Jiansheng; Li, Jingchao

doi:10.1039/d3bm00585b

Cited by 6 publications

(4 citation statements)

References 59 publications

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“…298 Similarly, nanoparticles composed of poly(vanillyl alcohol-co-oxalate) disintegrate into carbon dioxide bubbles and vanillyl alcohol when interacting with H 2 O 2 (Figure 8d). 299,300 Other designs in ultrasound-responsive polymeric micro-/ nanomaterials include polymersomes, 301 micelles, 302,303 hydrogels, 304,305 etc. While their acoustic signal generation for ultrasound imaging may be limited, their potential for ultrasound-initiated destruction or reconfiguration amplifies their utility in therapeutic applications, such as stimulustriggered drug delivery in ultrasound-mediated chemotherapy or SDT.…”

Section: State-of-the-art Ultrasound-basedmentioning

confidence: 99%

“…Other designs in ultrasound-responsive polymeric micro-/nanomaterials include polymersomes, micelles, , hydrogels, , etc. While their acoustic signal generation for ultrasound imaging may be limited, their potential for ultrasound-initiated destruction or reconfiguration amplifies their utility in therapeutic applications, such as stimulus-triggered drug delivery in ultrasound-mediated chemotherapy or SDT .…”

Section: Synthesis and Construction Of Ultrasound-based Micro-/nanosy...mentioning

confidence: 99%

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Ultrasound-Based Micro-/Nanosystems for Biomedical Applications

Huang,

Zheng,

Chang

et al. 2024

Chem. Rev.

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Due to the intrinsic non-invasive nature, cost-effectiveness, high safety, and real-time capabilities, besides diagnostic imaging, ultrasound as a typical mechanical wave has been extensively developed as a physical tool for versatile biomedical applications. Especially, the prosperity of nanotechnology and nanomedicine invigorates the landscape of ultrasound-based medicine. The unprecedented surge in research enthusiasm and dedicated efforts have led to a mass of multifunctional micro-/nanosystems being applied in ultrasound biomedicine, facilitating precise diagnosis, effective treatment, and personalized theranostics. The effective deployment of versatile ultrasound-based micro-/nanosystems in biomedical applications is rooted in a profound understanding of the relationship among composition, structure, property, bioactivity, application, and performance. In this comprehensive review, we elaborate on the general principles regarding the design, synthesis, functionalization, and optimization of ultrasound-based micro-/nanosystems for abundant biomedical applications. In particular, recent advancements in ultrasound-based micro-/nanosystems for diagnostic imaging are meticulously summarized. Furthermore, we systematically elucidate state-of-the-art studies concerning recent progress in ultrasound-based micro-/nanosystems for therapeutic applications targeting various pathological abnormalities including cancer, bacterial infection, brain diseases, cardiovascular diseases, and metabolic diseases. Finally, we conclude and provide an outlook on this research field with an in-depth discussion of the challenges faced and future developments for further extensive clinical translation and application.

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Section: State-of-the-art Ultrasound-basedmentioning

confidence: 99%

Section: Synthesis and Construction Of Ultrasound-based Micro-/nanosy...mentioning

confidence: 99%

Ultrasound-Based Micro-/Nanosystems for Biomedical Applications

Huang,

Zheng,

Chang

et al. 2024

Chem. Rev.

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show abstract

“…The released 1O2 induced immunogenic cell death and activated NLG919 prodrugs, enhancing anti-tumor immunity and inhibiting tumor growth in situ glioma-bearing mice. 67 …”

Section: Therapeutic Effect Of Multiplexresponse Pathways Of Hydrogel...mentioning

confidence: 99%

A Big Prospect for Hydrogel Nano-System in Glioma

Zhang,

Teng,

Xin

et al. 2024

IJN

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“…Other US-responsive polymeric designs include polymersomes, 67 nanovesicles, 68 micelles, 69,70 and hydrogels. 71,72 While their ability to generate detectable acoustic signal for US imaging is limited, their US-triggered destruction or rearrangement may enhance therapeutic applications in stimulus-induced drug delivery, e.g. in US-mediated chemotherapy delivery and sonodynamic therapy.…”

Section: Polymers and Design Features To Engineer Ultrasound-responsi...mentioning

confidence: 99%