Prodromal symptoms in epileptic patients: Clinical characterization of the pre-ictal phase

Scaramelli, A.; Braga, Patricia; Avellanal, Andrea; Bogacz, Alicia; Camejo, Claudia; Rega, I.; Messano, Tamara; Arciere, Beatriz

doi:10.1016/j.seizure.2008.10.007

Cited by 70 publications

(46 citation statements)

References 20 publications

(33 reference statements)

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“…It is important to recognize that many migraine sufferers report prominent nausea and vomiting with their headaches. CVS also shares some clinical features with epilepsy and even panic disorder . The compelling clinical connection between migraine, panic, and CVS suggests that CVS is a neurogenic disorder.…”

Section: Pathophysiology and Comorbid Conditionsmentioning

confidence: 99%

Cyclic vomiting syndrome: Pathophysiology, comorbidities, and future research directions

Hasler

Levinthal

Tarbell

et al. 2019

Neurogastroenterology Motil

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Cyclic vomiting syndrome (CVS) is characterized by severe episodic emesis in adults and children. Cannabinoid hyperemesis syndrome is an increasingly recognized CVS‐like illness that has been associated with chronic cannabis use. There are significant gaps in our understanding of the pathophysiology, clinical features, comorbidities, and effective management options of CVS. Recommendations for treating CVS are based on limited clinical data, as no placebo‐controlled, randomized trials have yet been conducted. Diseases associated with CVS, including migraine, mitochondrial disorders, autonomic dysfunction, and psychiatric comorbidities, provide clues about pathophysiologic mechanisms and suggest potential therapies. We review our current understanding of CVS and propose future research directions with the aim of developing effective therapy. Establishing a multicenter, standardized registry of CVS patients could drive research on multiple fronts including developing CVS‐specific outcome measures to broaden our understanding of clinical profiles, to serve as treatment end points in clinical trials, and to provide a platform for patient recruitment for randomized clinical trials. Such a robust database would also facilitate conduct of research that aims to determine the underlying pathophysiological mechanisms and genetic basis for CVS, as well as identifying potential biomarkers for the disorder. Soliciting government and industry support is crucial to establishing the necessary infrastructure and achieving these goals. Patient advocacy groups such as the Cyclic Vomiting Syndrome Association (CVSA), which partner with clinicians and researchers to disseminate new information, to promote ongoing interactions between patients, their families, clinicians, investigators, to support ongoing CVS research and education, must be an integral part of this endeavor.

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Section: Pathophysiology and Comorbid Conditionsmentioning

confidence: 99%

Cyclic vomiting syndrome: Pathophysiology, comorbidities, and future research directions

Hasler

Levinthal

Tarbell

et al. 2019

Neurogastroenterology Motil

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“…The behavioural signs of the prodromal phase are in line with this being a negative affective experience. Anxiety and mood changes are also reported in people with epilepsy during this phase, including tension and uneasiness, or, alternatively sadness, apathy and indifference (Scaramelli and others 2009). …”

Section: Are Seizures Per Se a Welfare Problem?mentioning

confidence: 99%

Epilepsy beyond seizures: a review of the impact of epilepsy and its comorbidities on health‐related quality of life in dogs

Packer

Volk

2015

Veterinary Record

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dog's quality of life (QoL) is of greatest importance to them above their seizure frequency; however, 5 much of the research into canine IE to date has focussed on seizure frequency, and how to reduce it 6 via anti-epileptic drug treatment. In humans, the impact of epilepsy upon QoL has been widely studied, 7 exploring its impact on physical health, but also the psychological health and cognitive capabilities of 8 affected individuals. This paper reviews the existing literature on canine IE, identifying potential 9 threats to QoL, drawing parallels from human epilepsy research. We suggest that canine IE poses 10 threats to both quality and quantity of life, with treatment interventions posing a fine balance of 11 potential benefits and harms to the patient. At present, little is known about the neurobehavioural, 12 emotional and cognitive effects of IE upon affected dogs, with further studies needed to establish the 13 extent to which unknown QoL-inhibiting comorbidities exist in the dog, to avoid their undertreatment. 14 More in-depth studies are required to objectively quantify the effects of IE on QoL

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“…1 Likewise, surveys of patients with epilepsy reported 6%-39% of patients recognize premonitory changes occurring in advance of impending seizures. [2][3][4] Anecdotally, premonitory symptoms have been noted by both patients and outside observers (e.g., family, friends, or coworkers). The advantage of being able to successfully predict impending disabling symptoms while still being relatively asymptomatic and unimpaired has led to the training of medical detection service dogs to alert their humans to impending problematic symptoms, such as hypoglycemia 5 and seizures.…”

Section: Introductionmentioning

confidence: 99%

Survey of Migraine Sufferers with Dogs to Evaluate for Canine Migraine-Alerting Behaviors

Marcus

Bhowmick²

2013

The Journal of Alternative and Complementary Medicine

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Objectives: Anecdotal reports suggest that changes in dog behavior might be used to predict impending migraine episodes. This survey was designed to investigate how companion dogs react to migraines that occur in their owners. Design: Online survey was available from January 4-31, 2012. Settings/location: Survey was conducted through SurveyMonkey, with links to the survey posted at Migraine.com and promoted through social media. Subjects: Adults ‡ 18 years old who experience migraine episodes and live with a dog were eligible to participate. Interventions and outcome measures: Participants completed an 18-question online survey that asked about participant demographics, migraines, and their dog's behavior before or during migraine episodes. Results: The survey was completed by 1029 adult migraineurs (94.9% women), with migraines typically occurring £ 8 days per month in 63.4% of participants. A recognized change in the dog's behavior prior to or during the initial phase of migraine was endorsed by 552 participants (53.7%), most commonly unusual attentiveness to the owner (39.9%). Among the 466 participants providing details about their dog's behavior with their migraines, 57.3% were able to identify dog alerting behavior before symptoms of a migraine attack would typically begin, with changes usually noticed within 2 hours before the onset of initial migraine symptoms. The dog's behavior was considered to be often or usually linked with the development of a migraine for 59.2% of migraineurs, and 35.8% of migraineurs endorsed beginning migraine treatments after the dog's behavior was recognized and before migraine symptoms had started. Participant demographics, migraine frequency, and breed of dog in the home were similar between the 470 participants with no alerting behavior endorsed and the 466 participants providing detailed alerting information. Conclusions: About one in four migraineurs living with a companion dog endorsed recognizing a change in their dog's behavior before recognizing initial symptoms of a migraine attack.

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Prodromal symptoms in epileptic patients: Clinical characterization of the pre-ictal phase

Cited by 70 publications

References 20 publications

Cyclic vomiting syndrome: Pathophysiology, comorbidities, and future research directions

Cyclic vomiting syndrome: Pathophysiology, comorbidities, and future research directions

Epilepsy beyond seizures: a review of the impact of epilepsy and its comorbidities on health‐related quality of life in dogs

Survey of Migraine Sufferers with Dogs to Evaluate for Canine Migraine-Alerting Behaviors

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