Prodigiosin: a fascinating and the most versatile bioactive pigment with diverse applications

Srilekha, V; Gudikandula, Krishna; Sreelatha, B.; Kumar, Enamala Manoj; Rajeshwari, K.

doi:10.1007/s43393-023-00192-1

Cited by 3 publications

(2 citation statements)

References 102 publications

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“…How does prodigiosin impair protein integrity in the ER? Considering its various antibiotic effects in both prokaryotic and eukaryotic cells [ 1 , 2 , 3 , 4 , 5 ], prodigiosin does not appear to be a sophisticated and specific inhibitor that blocks a selected biological process. Ref.…”

Section: Discussionmentioning

confidence: 99%

“…Prodigiosin is a secondary metabolite and red tripyrrole pigment produced by various bacteria such as the Serratia , Vibrio , Hahella , Pseudoalteromonas , and Streptomyces species ( Figure S1 ) [ 1 , 2 , 3 ]. Prodigiosin has received considerable attention due to its diverse biological activities, which are related to its antibacterial, antifungal, antimalarial, immunosuppressant, and anticancer properties [ 2 , 3 , 4 , 5 ]. Therefore, it and its derivatives are promising candidates for use as therapeutic drugs.…”

Section: Introductionmentioning

confidence: 99%

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Induction of Endoplasmic Reticulum Stress by Prodigiosin in Yeast Saccharomyces cerevisiae

Nguyen,

et al. 2024

CIMB

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Prodigiosin, a red pigment produced by numerous bacterial species, exerts various antibiotic effects on prokaryotic and eukaryotic organisms. For instance, human carcinoma cell lines appear to suffer from endoplasmic reticulum (ER) stress in the presence of prodigiosin. Here, we demonstrated that prodigiosin also triggers the unfolded-protein response (UPR), which is a cytoprotective response against ER stress, in yeast Saccharomyces cerevisiae. An S. cerevisiae mutant carrying a UPR-deficient mutation was hypersensitive to prodigiosin. Our observations cumulatively indicate that protein folding in the ER is impaired by prodigiosin, illustrating a new mode of action.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Induction of Endoplasmic Reticulum Stress by Prodigiosin in Yeast Saccharomyces cerevisiae

Nguyen,

et al. 2024

CIMB

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Microbial Pigments: Major Groups and Industrial Applications

Barreto,

Casanova,

Junior

et al. 2023

Microorganisms

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Microbial pigments have many structures and functions with excellent characteristics, such as being biodegradable, non-toxic, and ecologically friendly, constituting an important source of pigments. Industrial production presents a bottleneck in production cost that restricts large-scale commercialization. However, microbial pigments are progressively gaining popularity because of their health advantages. The development of metabolic engineering and cost reduction of the bioprocess using industry by-products opened possibilities for cost and quality improvements in all production phases. We are thus addressing several points related to microbial pigments, including the major classes and structures found, the advantages of use, the biotechnological applications in different industrial sectors, their characteristics, and their impacts on the environment and society.

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Mimicking Marine Conditions to Improve Prodigiosin Yields in Bioreactor

Pereira,

de Carvalho

2024

Processes

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Prodigiosin is a red bacterial pigment with great potential as a natural dye and drug precursor, while presenting several pharmacological properties, including antimicrobial and anticancer activities. Its commercialization for biomedical applications, however, remains scarce. The major limitations are related to the lack of efficient bioprocesses and scaling up from laboratory to production. In the present work, the upstream process for prodigiosin production was developed using a marine Serratia rubidaea isolated from a sample collected near a shallow-water hydrothermal vent. The yield of product per biomass was found to be influenced by the cell concentration in the inoculum. The system was scaled up to 2 L stirred tank reactors with two different vessel geometries. It was shown that the vessel geometry and a cascade control mode for regulating the dissolved oxygen concentration influenced the volumetric oxygen mass transfer coefficient (kLa) and thus prodigiosin production. To improve product yields, strategies to mimic the aeration conditions found at the sampling site were tested. When the inoculum was grown for 5 h at 200 rpm and for 19 h at 25 rpm, which significantly decreased the oxygen available, the cells produced 588.2 mgproduct/gbiomass, corresponding to a production of 1066.2 mg of prodigiosin in 24 h and a productivity of 36.1 mgproduct/(L.h). This is a 3.7-fold increase in prodigiosin yield and a 4.5-fold increase in productivity in relation to when no particular strategy was promoted. Additionally, it was shown that lipid analysis and flow cytometry may be used as reliable at-line analytical tools, allowing the monitoring of cell condition and prodigiosin production during fermentation.

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Prodigiosin: a fascinating and the most versatile bioactive pigment with diverse applications

Cited by 3 publications

References 102 publications

Induction of Endoplasmic Reticulum Stress by Prodigiosin in Yeast Saccharomyces cerevisiae

Induction of Endoplasmic Reticulum Stress by Prodigiosin in Yeast Saccharomyces cerevisiae

Microbial Pigments: Major Groups and Industrial Applications

Mimicking Marine Conditions to Improve Prodigiosin Yields in Bioreactor

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