Procyanidins from Tormentil: Fractionation and Study of the Anti-radical Activity towards Superoxide Anion.

Vennat, B.; Bos, MarieAndree; Pourrat, A; Bastide, P

doi:10.1248/bpb.17.1613

Cited by 56 publications

(31 citation statements)

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“…Studies with Potentilla extracts containing condensed tannins and their monomers show that the antioxidative properties of these extracts are determined not only by their qualitative composition but also by the degree of polymerization of their compounds. It was observed that procyanidin oligomers and dimers isolated from the Potentilla erecta rhizome had much higher activity in that direction compared to their monomers, whereas pentamers and hexamers had an elastase inhibiting capacity (Vennat et al, 1994;Bos et al, 1996). It is worth mentioning that these activities are also displayed by tannins studied by French authors, that were isolated from other plants from the Potentilla species such as Potentilla anserina, Potentilla argentea, Potentilla aurea, Potentilla fruticosa, Potentilla palustris, Potentilla reptans and Potentilla tabernaemontani ASCH (Lamaison et al, 1990).…”

Section: In Vitro Experimentsmentioning

confidence: 99%

Potentilla—A review of its phytochemical and pharmacological profile

Tomczyk

Latté²

2009

Journal of Ethnopharmacology

238

213

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Section: In Vitro Experimentsmentioning

confidence: 99%

Potentilla—A review of its phytochemical and pharmacological profile

Tomczyk

Latté²

2009

Journal of Ethnopharmacology

238

213

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“…Besides the use of Tormentil root ( Potentilla tormentilla ) for treatment of wounds, ulcers, bleeding and inflammation, Tormentilla was additionally shown to have antiinflammatory, immunostimulating and antiviral effects [48,49,50]. In various European folk medicines, it is also recommended as an important remedy for treating diarrhea.…”

Section: Resultsmentioning

confidence: 99%

Management of Acute Gastroenteritis in Children: A Systematic Review of Anthroposophic Therapies

et al. 2018

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Background: Acute gastroenteritis in children accounts for about 10% of hospital admissions and is still one of the major causes of death worldwide. As many children are treated with complementary and alternative medicine (CAM) and anthroposophic medicine, respectively, especially in Europe, the aim of this review was to descriptively present published anthroposophic therapies applied for the treatment of acute gastroenteritis in childhood. Methods: A complex search strategy recording a broad spectrum of CAM therapies was developed to identify anthroposophic therapy options for the treatment of gastroenteritis in children. The search was conducted in 4 general scientific as well as 3 CAM-specific databases. Results: In total, 3,086 articles were identified and screened for anthroposophic related content. The majority of hits deal with nutritional/dietary therapies. Articles considering anthroposophic approaches constitute only 3.1% (7/227) of all CAM-related articles. Among these articles 2 observational studies, 3 experience reports and 2 reviews were identified. In the experience reports, a variety of anthroposophic remedies was recommended but mostly unsupported by scientific evidence. However, observational studies for the anthroposophic medications, Bolus alba comp. and Gentiana comp., were detected. Additionally, studies investigating the efficacy and safety of Chamomilla, Ipecacuanha, Podophyllum or Tormentilla preparations in homeopathy and phytomedicine, respectively, were presented. Conclusions: Most CAM-associated therapies for gastroenteritis in childhood comprise dietary recommendations. Studies concerning anthroposophic approaches and medications, respectively, are deficient. The results of this study underline that effort is needed to evaluate anthroposophic therapies in a clinical setting.

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“…It has been reported that proanthocyanidins possess a number of beneficial effects: radical scavenging activity in vitro (Vennat et al, 1994), antimutagenic behaviour in vitro (Liviero et al, 1994), antitumourpromoting behaviour in vivo (Gali et al, 1994), antifungal effects in vitro (Eberhardt and Young, 1994), antiviral behaviour both in vitro and in vivo (Barnard et al, 1993), antidental-plaque formation in vivo (Matsudaira et al, 1998), antiulcer effects in vivo (Vennat et al, 1989), antiallergic activity in vitro (Kanda et al, 1998) and antihypertensive activity in vivo (Cheng et al, 1993). Proanthocyanidins have been used as medications aimed at protecting the capillary vessels (Dartenuc et al, 1980); as cosmetics to protect the skin (Wayne, 1996); and as antioxidants in foods and beverages.…”

Section: Effects On the Scalpmentioning

confidence: 99%

The first clinical trial of topical application of procyanidin B‐2 to investigate its potential as a hair growing agent

Takahashi

Kamimura

Yokoo

et al. 2001

Phytotherapy Research

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Procyanidin B-2 is a compound we have identified in apple which acts as a growth-promoting factor on murine hair epithelial cells. This report describes our investigation of the hair-growing effects of 1% procyanidin B-2 tonic after sequential use for 4 months. A double-blind clinical trial was performed, involving a total of 29 subjects (procyanidin B-2, 19 men; placebo, 10 men). No adverse side effects were observed in either group. In the procyanidin B-2 group, 78.9% showed an increased mean value of hair diameter, whereas only 30.0% in the placebo group showed any increase (p < 0.02, Fisher's exact probability test). The increased ratio of hairs measuring more than 40 microm in diameter after 4 months of procyanidin B-2 treatment was significantly higher than that of the placebo controls (p < 0.05, two-sample-t-test). The increase in number of total hairs in the designated scalp area (0.25 cm(2)) of procyanidin B-2 subjects after a 4 month trial was significantly greater than that of the placebo controls (procyanidin-B-2, 3.67 +/- 4.09 (mean +/- SD)/0.25 cm(2); placebo, -2.54 +/- 4.00/0.25 cm(2); p < 0.001, two-sample t-test). Procyanidin B-2 therapy shows potential as a promising cure for male pattern baldness.

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Procyanidins from Tormentil: Fractionation and Study of the Anti-radical Activity towards Superoxide Anion.

Cited by 56 publications

References 0 publications

Potentilla—A review of its phytochemical and pharmacological profile

Potentilla—A review of its phytochemical and pharmacological profile

Management of Acute Gastroenteritis in Children: A Systematic Review of Anthroposophic Therapies

The first clinical trial of topical application of procyanidin B‐2 to investigate its potential as a hair growing agent

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