Procyanidins from Tormentil: Antioxidant Properties towards Lipoperoxidation and Anti-Elastase Activity.

Bos, MarieAndree; Vennat, B.; Meunier, M.A.F. Louise; Pouget, M. P.; Pourrat, A; Fialip, J.

doi:10.1248/bpb.19.146

Cited by 38 publications

(22 citation statements)

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“…Studies with Potentilla extracts containing condensed tannins and their monomers show that the antioxidative properties of these extracts are determined not only by their qualitative composition but also by the degree of polymerization of their compounds. It was observed that procyanidin oligomers and dimers isolated from the Potentilla erecta rhizome had much higher activity in that direction compared to their monomers, whereas pentamers and hexamers had an elastase inhibiting capacity (Vennat et al, 1994;Bos et al, 1996). It is worth mentioning that these activities are also displayed by tannins studied by French authors, that were isolated from other plants from the Potentilla species such as Potentilla anserina, Potentilla argentea, Potentilla aurea, Potentilla fruticosa, Potentilla palustris, Potentilla reptans and Potentilla tabernaemontani ASCH (Lamaison et al, 1990).…”

Section: In Vitro Experimentsmentioning

confidence: 99%

Potentilla—A review of its phytochemical and pharmacological profile

Tomczyk

Latté²

2009

Journal of Ethnopharmacology

238

213

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Section: In Vitro Experimentsmentioning

confidence: 99%

Potentilla—A review of its phytochemical and pharmacological profile

Tomczyk

Latté²

2009

Journal of Ethnopharmacology

238

213

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“…It is said to be effective in the treatment of diarrhoea and bowel inflammation. Tormentil contains a high concentration of tannins known to have a potent superoxide‐scavenging effect 37 , . 38 …”

Section: Discussionmentioning

confidence: 99%

Antioxidant effects of herbal therapies used by patients with inflammatory bowel disease: an in vitro study

Langmead

Dawson

Hawkins

et al. 2002

Aliment Pharmacol Ther

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Background: Herbal remedies used by patients for treatment of inflammatory bowel disease include slippery elm, fenugreek, devil’s claw, Mexican yam, tormentil and wei tong ning, a traditional Chinese medicine. Reactive oxygen metabolites produced by inflamed colonic mucosa may be pathogenic. Aminosalicylates (5‐ASA) are antioxidant and other such agents could be therapeutic. Aims: To assess the antioxidant effects of herbal remedies in cell‐free oxidant‐generating systems and inflamed human colorectal biopsies. Methods: Luminol‐enhanced chemiluminescence in a xanthine/xanthine oxidase cell‐free system was used to detect superoxide scavenging by herbs and 5‐ASA, and fluorimetry to define peroxyl radical scavenging using a phycoerythrin degradation assay. Chemiluminescence was used to detect herbal effects on generation of oxygen radicals by mucosal biopsies from patients with active ulcerative colitis. Results: Like 5‐ASA, all herbs, except fenugreek, scavenged superoxide dose‐dependently. All materials tested scavenged peroxyl dose‐dependently. Oxygen radical release from biopsies was reduced after incubation in all herbs except Mexican yam, and by 5‐ASA. Conclusions: All six herbal remedies have antioxidant effects. Fenugreek is not a superoxide scavenger, while Mexican yam did not inhibit radical generation by inflamed biopsies. Slippery elm, fenugreek, devil’s claw, tormentil and wei tong ning merit formal evaluation as novel therapies in inflammatory bowel disease.

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“…cumene hydroperoxide)-induced damage of fetal bovine vascular endothelial cells [92]. Iron (Fe 2+ - adenosine diphosphate (ADP)) in combination with ascorbic acid leads to lipid peroxidation in rat liver microsomes, which is inhibited by monomeric and oligomeric flavan-3-ols [89, 93]. …”

Section: Introductionmentioning

confidence: 99%

Masquelier’s grape seed extract: from basic flavonoid research to a well-characterized food supplement with health benefits

Weseler¹,

Bast²

2017

Nutr J

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Careful characterization and standardization of the composition of plant-derived food supplements is essential to establish a cause-effect relationship between the intake of that product and its health effect. In this review we follow a specific grape seed extract containing monomeric and oligomeric flavan-3-ols from its creation by Jack Masquelier in 1947 towards a botanical remedy and nutraceutical with proven health benefits. The preparation’s research history parallels the advancing insights in the fields of molecular biology, medicine, plant and nutritional sciences during the last 70 years. Analysis of the extract’s flavanol composition emerged from unspecific colorimetric assays to precise high performance liquid chromatography - mass spectrometry and proton nuclear magnetic resonance fingerprinting techniques. The early recognition of the preparation’s auspicious effects on the permeability of vascular capillaries directed research to unravel the underlying cellular and molecular mechanisms. Recent clinical data revealed a multitude of favorable alterations in the vasculature upon an 8 weeks supplementation which summed up in a health benefit of the extract in healthy humans. Changes in gene expression of inflammatory pathways in the volunteers’ leukocytes were suggested to be involved in this benefit. The historically grown scientific evidence for the preparation’s health effects paves the way to further elucidate its metabolic fate and molecular action in humans.

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Procyanidins from Tormentil: Antioxidant Properties towards Lipoperoxidation and Anti-Elastase Activity.

Cited by 38 publications

References 0 publications

Potentilla—A review of its phytochemical and pharmacological profile

Potentilla—A review of its phytochemical and pharmacological profile

Antioxidant effects of herbal therapies used by patients with inflammatory bowel disease: an in vitro study

Masquelier’s grape seed extract: from basic flavonoid research to a well-characterized food supplement with health benefits

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