Procyanidin B2 ameliorates the progression of osteoarthritis: An in vitro and in vivo study

Cai, Wenxiang; Zhang, Yubiao; Jin, Wenyi; Wei, Sixing; Chen, Junwen; Zhong, Changheng; Zhong, Yujian; Tu, Chen; Peng, Hao

doi:10.1016/j.intimp.2022.109336

Cited by 16 publications

(16 citation statements)

References 45 publications

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“…The primary antibodies employed encompassed anti‐Vimentin (diluted 1:200) and anti‐E‐cadherin (diluted 1:200) antibodies. 31 …”

Section: Methodsmentioning

confidence: 99%

Integrating single‐cell and multi‐omic approaches reveals Euphorbiae Humifusae Herba‐dependent mitochondrial dysfunction in non‐small‐cell lung cancer

Zhang,

Zhao,

et al. 2024

J Cellular Molecular Medi

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Euphorbiae Humifusae Herba (EHH) is a pivotal therapeutic agent with diverse pharmacological effects. However, a substantial gap exists in understanding its pharmacological properties and anti‐tumour mechanisms. This study aimed to address this gap by exploring EHH's pharmacological properties, identifying NSCLC therapy‐associated protein targets, and elucidating how EHH induces mitochondrial disruption in NSCLC cells, offering insights into novel NSCLC treatment strategies. String database was utilized to explore protein–protein interactions. Subsequently, single‐cell analysis and multi‐omics further unveiled the impact of EHH‐targeted genes on the immune microenvironment of NSCLC, as well as their influence on immunotherapeutic responses. Finally, both in vivo and in vitro experiments elucidated the anti‐tumour mechanisms of EHH, specifically through the assessment of mitochondrial ROS levels and alterations in mitochondrial membrane potential. EHH exerts its influence through engagement with a cluster of 10 genes, including the apoptotic gene CASP3. This regulatory impact on the immune milieu within NSCLC holds promise as an indicator for predicting responses to immunotherapy. Besides, EHH demonstrated the capability to induce mitochondrial ROS generation and perturbations in mitochondrial membrane potential in NSCLC cells, ultimately leading to mitochondrial dysfunction and consequent apoptosis of tumour cells. EHH induces mitochondrial disruption in NSCLC cells, leading to cell apoptosis to inhibit the progress of NSCLC.

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“…The primary antibodies employed encompassed anti‐Vimentin (diluted 1:200) and anti‐E‐cadherin (diluted 1:200) antibodies. 31 …”

Section: Methodsmentioning

confidence: 99%

Integrating single‐cell and multi‐omic approaches reveals Euphorbiae Humifusae Herba‐dependent mitochondrial dysfunction in non‐small‐cell lung cancer

Zhang,

Zhao,

et al. 2024

J Cellular Molecular Medi

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“…In this context, procyanidins possess anti-inflammatory properties that could help alleviate inflammatory responses and mitigate cartilage degeneration [ 16 ]. Existing research indicates that procyanidins can inhibit the NF-κB pathway and reduce cartilage cell SASP and apoptosis triggered by IL-1β, thus ameliorating the progression of PTOA [ 37 , 38 ]. Additionally, procyanidins might exert an anti-apoptotic effect on cartilage cells through the Nrf2/BAX/Bcl-2 pathway, facilitating damaged cell survival and repair, thereby supporting joint recovery and regeneration [ 38 , 39 ].…”

Section: Mechanisms Of Procyanidins In Repairing Cartilage Injury Aft...mentioning

confidence: 99%

Research progress of procyanidins in repairing cartilage injury after anterior cruciate ligament tear

Chen,

Li,

et al. 2024

Heliyon

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“…The senescence-associated secretory phenotype (SASP) is associated with the biological actions of senescent cells in producing inflammation-promoting factors. Procyanidin B2 (PCB2), comprised of two molecules of flavan-3-ol (−)-epicatechin, has been reported to ameliorate IL-1β-induced expression of SASP factors, inflammatory responses, and ECM degradation by mediating the NRF2 and NF-κB signaling pathways in rat chondrocytes ( 131 ). Similarly, Rhofolin exhibits significant effects against the expression of SASP factors and the phenotype of senescent cells by activating NRF2 signaling and suppressing the NF-κB pathway in IL-1β-treated chondrocytes ( 132 ).…”

Section: Natural Flavonoids Exhibit Protective Activity Against Oa De...mentioning

confidence: 99%

The protective activity of natural flavonoids against osteoarthritis by targeting NF-κB signaling pathway

Zhou

2023

Front. Endocrinol.

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Osteoarthritis (OA) is a typical joint disease associated with chronic inflammation. The nuclear factor-kappaB (NF-κB) pathway plays an important role in inflammatory activity and inhibiting NF-κB-mediated inflammation can be a potential strategy for treating OA. Flavonoids are a class of naturally occurring polyphenols with anti-inflammatory properties. Structurally, natural flavonoids can be divided into several sub-groups, including flavonols, flavones, flavanols/catechins, flavanones, anthocyanins, and isoflavones. Increasing evidence demonstrates that natural flavonoids exhibit protective activity against the pathological changes of OA by inhibiting the NF-κB signaling pathway. Potentially, natural flavonoids may suppress NF-κB signaling-mediated inflammatory responses, ECM degradation, and chondrocyte apoptosis. The different biological actions of natural flavonoids against the NF-κB signaling pathway in OA chondrocytes might be associated with the differentially substituted groups on the structures. In this review, the efficacy and action mechanism of natural flavonoids against the development of OA are discussed by targeting the NF-κB signaling pathway. Potentially, flavonoids could become useful inhibitors of the NF-κB signaling pathway for the therapeutic management of OA.

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Procyanidin B2 ameliorates the progression of osteoarthritis: An in vitro and in vivo study

Cited by 16 publications

References 45 publications

Integrating single‐cell and multi‐omic approaches reveals Euphorbiae Humifusae Herba‐dependent mitochondrial dysfunction in non‐small‐cell lung cancer

Integrating single‐cell and multi‐omic approaches reveals Euphorbiae Humifusae Herba‐dependent mitochondrial dysfunction in non‐small‐cell lung cancer

Research progress of procyanidins in repairing cartilage injury after anterior cruciate ligament tear

The protective activity of natural flavonoids against osteoarthritis by targeting NF-κB signaling pathway

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