Procollagen type I N‐terminal peptide in preterm infants is associated with growth during the first six months post‐term

Lagemaat, Monique van de; Veer, Eveline van der; Weissenbruch, Mirjam M. van; Lafeber, Harrie N.; Rotteveel, Joost

doi:10.1111/cen.12454

Cited by 5 publications

(3 citation statements)

References 32 publications

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“… 27 Only 6 SGA infants (1.3%) were included out of 456 eligible participants in our study, while neonatal bone turnover in SGA cases may differ from bone metabolism in AGA subjects. 28 Nevertheless, no previous studies have investigated both TRACP-5b and NTx simultaneously in the context of vitamin D deficiency during early infancy, making our studies significant.…”

Section: Discussionmentioning

confidence: 99%

Discordant responses of bone formation and absorption markers in Japanese infants with vitamin D deficiency: a comprehensive matched case–control study

Takahashi,

Ikeda,

Hara-Isono

et al. 2024

JBMR Plus

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Vitamin D deficiency during infancy has been associated with increased bone turnover rate and bone mineral loss. However, few studies have examined bone turnover markers (BTMs) for both bone formation and resorption in infants with vitamin D deficiency. Here, we analyzed serum concentrations of 25(OH)D, intact parathormone (iPTH), and BTMs including total alkaline phosphatase (ALP), tartrate-resistant acid phosphatase isoform 5b (TRACP-5b), and serum type I collagen N-telopeptide (NTx) as well as basic clinical characteristics of 456 infants (626 samples) aged less than 12 months born at Saitama City Hospital, Japan (latitude 35.9° North) between January 2021 and December 2022. 116 infants (147 samples) were classified as having vitamin D deficiency (25(OH)D < 12.0 ng/mL), and 340 infants (479 samples) had sufficient vitamin D levels (25(OH)D ≥ 12.0 ng/mL). In addition to 25(OH)D and ALP, both TRACP-5b and sNTx were measured in 331 infants (418 samples), while 90 infants (105 samples) had only TRACP-5b only measured and 101 infants (103 samples) had only sNTx measured. Statistical comparison of 104 subjects each in the vitamin D deficiency and sufficiency groups after matching for the background characteristics revealed that the vitamin D deficiency group had significantly higher levels of ALP and iPTH compared with the sufficiency group (p = <0.0001, 0.0012, respectively). However, no significant differences were found in TRACP-5b and NTx levels between the two groups (p = 0.19, 0.08, respectively). Our findings suggest discordant responses between bone formation and resorption markers in subclinical vitamin D deficiency during infancy.

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Section: Discussionmentioning

confidence: 99%

Discordant responses of bone formation and absorption markers in Japanese infants with vitamin D deficiency: a comprehensive matched case–control study

Takahashi,

Ikeda,

Hara-Isono

et al. 2024

JBMR Plus

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“…There are planty of studies concerning bone mineralization in children born small for gestational age (SGA). Van de Lagemaat showed that six months post-term SGA preterms have lower bone accretion and in another work she proved decreased collagen type I synthesis in SGA children [2,3]. Longhi also confirmed that children born as SGA seem to have smaller and weaker bones [4].…”

Section: Introductionmentioning

confidence: 89%

Bone Turnover Markers during Growth Hormone Therapy Short Stature Children Born as SGA

Alicja,

Maciej,

Skorupa

et al. 2024

Preprint

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Growth hormone therapy (GHT) can improve growth velocity and final height but can also accelerated the process of bone growth, which is related to structural bone modelling, both in formation and resorption. The study evaluated the capacity of bone turnover markers to predict early growth response to one year GHT in short stature children born as small for gestational age (SGA). 25 prepubertal SGA children were included. We have estimated P1NP (N-terminal procollagen type 1), CTX (C-terminal telopeptide of collagen type I), P3NP (N-terminal procollagen type III), NT-pro-CNP (amino-terminal C-type natriuretic peptide) and Ca-P metabolism using standard ECLIA, IRA and ELISA methods. A statistically significant increase in bone resorption markers (Ctx ) was found both at 6 and 12 months. P1NP bone markers increased at 6 months and after 12 months of therapy. The P3NP marker of collagen synthesis also increased after 12 months of therapy. We obtained significant increases in phosphorus levels at 6 and 12 months and similarly ALP. We have found a significant correlation between height (cm) and Ctx after 6 -12 months as well as P1NP / height (SD) after 12 months. Calcium levels significantly correlated with height (SD) after 12 months. We find a strong reaction of bone resorption and bone formation markers during growth hormone therapy that may determine their selection as prediction of GH treatment outcome in SGA children. However, the issue requires further research.

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“…OC also plays an important role in energy metabolism as a bone-derived hormone. Bone resorption markers mainly comprise collagen type I degradation products: cross-linked N- and C-telopeptides (NTx and CTx) [10, 11]. Additionally, C-type natriuretic peptide plays an essential role in bone and cartilage growth, while its stable product, amino-terminal propeptide of C-type natriuretic peptide (NT-proCNP), serves as a growth plate activity marker [12].…”

Section: Introductionmentioning

confidence: 99%

The Clinical and Biochemical Predictors of Bone Mass in Preterm Infants

et al. 2016

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BackgroundMetabolic bone disease of prematurity still occurs in preterm infants, although a significant improvement in neonatal care has been observed in recent decades. Dual-energy X-ray absorptiometry (DXA) is the precise technique for assessing bone mineral content (BMC) in preterm infants, but is not widely available.AimTo investigate the clinical and biochemical parameters, including bone metabolism markers as potential predictors of BMC, in preterm infants up to 3 months corrected age (CA).Materials and MethodsCa-P homeostasis, iPTH, 25-hydroxyvitamin D, osteocalcin, N-terminal propeptide, cross-linked C-telopeptide and amino-terminal pro C-type natriuretic peptide and the DXA scans were prospectively performed in 184 preterm infants (≤ 34 weeks’ gestation) between term age and 3 mo CA. Lower bone mass was defined as BMC below or equal to respective median value for the whole study group, rounded to the nearest whole number.ResultsThe appropriate quality DXA scans were available for 160 infants (87%) examined at term and for 130 (71%) tested at 3 mo CA. Higher iPTH level was the only independent predictor of lower BMC at term, whereas lower BMC at 3 mo CA was associated both with lower urinary phosphate excretion and higher serum osteocalcin level. ROC analysis showed that iPTH >43.6 pg/mL provided 40% sensitivity and 88% specificity in identification of preterm infants with lower BMC at term. In turn, urinary phosphate excretion (TRP>97% or UP/Cr ≤0.74 mg/mg) and serum osteocalcin >172 ng/mL provided 40% sensitivity and 93% specificity in identification of infants with decreased BMC at 3 mo CA.ConclusionSerum iPTH might to be a simple predictor of reduced BMC in preterm infants at term age, but urinary phosphate excretion and serum osteocalcin might predict reduced BMC at 3 mo CA. These results represent a promising diagnostic tool based on simple, widely available biochemical measurements for bone mass assessment in preterm infants.

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Procollagen type I N‐terminal peptide in preterm infants is associated with growth during the first six months post‐term

Cited by 5 publications

References 32 publications

Discordant responses of bone formation and absorption markers in Japanese infants with vitamin D deficiency: a comprehensive matched case–control study

Discordant responses of bone formation and absorption markers in Japanese infants with vitamin D deficiency: a comprehensive matched case–control study

Bone Turnover Markers during Growth Hormone Therapy Short Stature Children Born as SGA

The Clinical and Biochemical Predictors of Bone Mass in Preterm Infants

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