Procoagulant Platelets

Abstract

There are two well-known subpopulations of activated platelets: pro-aggregatory and procoagulant. Procoagulant platelets represent a subpopulation of activated platelets, which are morphologically and functionally distinct from pro-aggregatory ones. Although various names have been used to describe these platelets in the literature (CoaT, CoaTed, highly activated, ballooned, capped, etc.), there is a consensus on their phenotypic features including exposure of high levels of phosphatidylserine (PSer) on the surface; decreased aggregatory and adhesive properties; support of active tenase and prothrombinase complexes; maximal generation by co-stimulation of glycoprotein VI (GPVI) and protease-activated receptors (PAR). In this chapter, morphologic and functional features of procoagulant platelets, as well as the mechanisms of their formation, will be discussed.

Redox stress in COVID-19: Implications for hematologic disorders

“…During this process, electron leakage generates ROS that are physiologically scavenged by catalase, a mitochondrial antioxidant enzyme. Platelets produce mitochondrial ROS when stimulated [ 53 ]. Oxidant generation in this context increases phosphatidylserine externalization to promote the tenase and prothrombinase complexes for procoagulant activity.…”