Processing of sensory information

Angel, A.

doi:10.1016/0301-0082(77)90018-1

Cited by 46 publications

(20 citation statements)

References 817 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This figure is very close to my measurement. Although tonic responses have been observed in the vb neurones of the cat (Baker, 1971;Tsumoto & Nakamura, 1974) and the monkey (Mountcastle, Poggio & Werner, 1963), previous authors who studied responses of the rat vb (Waite, 1973b;Angel, 1977) reported only phasic responses. The present finding that one group of the rat vb neurones showed tonic responses to appropriate stimuli suggests that with regard to the sensory organization of the thalamic vb, there is no essential difference among rat, cat and monkey.…”

Section: Discussionmentioning

confidence: 96%

Electrophysiological and sensory properties of the thalamic reticular neurones related to somatic sensation in rats.

Sugitani¹

1979

The Journal of Physiology

View full text Add to dashboard Cite

SUMMARY1. In urethane-anaesthetized rats, studies were made on unit discharges of neurones of the thalamic reticular nucleus (tr) receiving the somatosensory input. Such units were found distributed in a part of the tr (s-tr) surrounding the anterior and anterolateral borders of the ventrobasal nuclear complex (vb).2. A series of five to ten bursts of grouped discharges were elicited in the s-tr neurones as orthodromic responses to single shock stimulation of the medial lemniscus (ml) or the somatosensory cortex (smc). In contrast to this, the vb relay cells were fired by ml impulses only once at short latencies, though later there occurred a series of two to three bursts of grouped discharges. The same response pattern was seen by stimulating the smc, except that the initial response to smc shocks was of antidromic origin.3. The mean response latency of the s-tr neurones to ml shocks was about 0-6 msec longer than that of the vb relay cells. Ml fibres connected to the s-tr neurones had the same distribution of conduction velocity as those connected to the vb relay cells. It is suggested that most, if not all, of the s-tr neurones are innervated by axon collaterals of the vb relay cells.4. About half the s-tr units were activated from vibrissae. For most of the remaining half either movements of hairs or touch to the skin were effective. In the vb, the units discharged by movements of hairs were most numerous and those activated from vibrissae were less frequent. While responses of the s-tr neurones to adequate stimuli were almost exclusively of phasic type, 30 % of the responses of the vb relay cells were tonic and the remainder were phasic.5. By exploring the tr extensively, the s-tr was found to be contiguous caudally to the perigeniculate reticular nucleus which is immediately adjacent to the dorsal lateral geniculate nucleus and contains reticular neurones activated by visual stimuli. Though few in number, units were found in the tr which received a convergence of somatosensory and visual inputs or of somatosensory and auditory inputs.

show abstract

Section: Discussionmentioning

confidence: 96%

Electrophysiological and sensory properties of the thalamic reticular neurones related to somatic sensation in rats.

Sugitani¹

1979

The Journal of Physiology

View full text Add to dashboard Cite

show abstract

“…The two simplest are (a) that the responsiveness of the cortex itself is decreased by anaesthetic chemicals or (b) the sensory message is attenuated somewhere along the afferent pathway to the cerebral cortex or additionally, a combination of these two. The evidence so far (see Angel, 1977; suggests that the second of the above alternatives is the most likely.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Anaesthetic Agents on Cerebral Cortical Responses in the Rat

Angel

Gratton

1982

British J Pharmacology

Self Cite

View full text Add to dashboard Cite

1 In rats, surgically anaesthetized with Urethane, an increase in the depth of anaesthesia upon administration of ethyl carbamate (Urethane), pentobarbitone sodium (Nembutal), thiopentone sodium (Intraval), althesin, ketamine, trichloroethylene, halothane, methoxyflurane, diethyl ether, ethyl-vinyl ether, cyclopropane, enflurane or chloroform resulted in a dose-dependent increase in the latency, and decrease in the amplitudes of the initial positive and negative components of the short latency cortical response to electrical stimuli applied to the forepaw. 2 The same changes were seen when starting from initially unanaesthetized rats and anaesthetizing them with Urethane. 3 With all the inhalational agents used these changes lasted for as long as the administration except with nitrous oxide where the changes in the cortical response were transient.4 The tranquillizing agents diazepam, chlordiazepoxide, and haloperidol showed no such action. Chloral hydrate and chlorpromazine, on the other hand, produced moderate changes in the evoked cortical response similar to those seen with the other anaesthetic agents used.

show abstract

“…The decrease of amplitudes was accompanied by a dose-dependent and parallel increase of the peak latencies of P1 and N2. Angel (1977) and Shaw & Cant (1981). The time of stimulation is indicated by the dotted line.…”

Section: Excitatory Transmission In the Thalamusmentioning

confidence: 99%

“…After synaptic transmission in the v.b.t.n. the nervous impulses which generate s.e.p.s travel through thalamocortical fibres to the sensorimotor region of the cortex (Angel, 1977;Allison & Hume, 1981 Rats were initially anaesthetized with 50 mg pentobarbitone kg-' intraperitoneally (I.P.) and mounted in a stereotaxic frame.…”

Section: T Klockgethermentioning

confidence: 99%

Excitatory amino acid receptor‐mediated transmission of somatosensory evoked potentials in the rat thalamus.

Klockgether

1987

The Journal of Physiology

View full text Add to dashboard Cite

SUMMARY1. To examine the role of excitatory amino acid receptors in the rat ventrobasal thalamic nucleus (v.b.t.n.) for the transmission of cortical somatosensory evoked potentials (s.e.p.s), potentials were recorded from the somatosensory cortex of barbiturate-anaesthetized and of unanaesthetized awake rats. The effects of microapplications of the selective N-methyl-D-aspartate (NMDA) antagonist (-)-2-amino-7-phosphono-heptanoate ((-)AP7) and the broad-spectrum excitatory amino acid antagonist 1-(p-chlorobenzoyl)-piperazine-2,3-dicarboxylate (pCB-PzDA) into the thalamus on the amplitudes and latencies of cortical potentials were measured.2. To define the receptor specificity of local microinjections of (-)AP7 and pCB-PzDA electroencephalogram (e.e.g.) recordings were made from the immediate vicinity of the injection cannula within the thalamus. (-)AP7 selectively antagonized epileptic discharges induced by NMDA, but not those by kainate, whereas pCB-PzDA antagonized epileptic discharges induced by both.3. In both anaesthetized and unanaesthetized rats, microapplications of pCB-PzDA into the thalamus suppressed transmission of cortical potentials as indicated by a decrease of their amplitudes and an increase of their peak latencies.Further experiments in anaesthetized rats showed that pCB-PzDA exerted its effects in a dose-dependent and site-specific way. 4. In both anaesthetized and unanaesthetized rats, microapplications of (-)AP7 into the ventrobasal thalamus did not affect cortical potentials.5. These results are consistent with the assumption that an excitatory amino acid serves as transmitter at thalamic synapses mediating transmission of cortical potentials, and that this transmitter interacts preferentially with non-NMDA receptors.

show abstract

Processing of sensory information

Cited by 46 publications

References 817 publications

Electrophysiological and sensory properties of the thalamic reticular neurones related to somatic sensation in rats.

Electrophysiological and sensory properties of the thalamic reticular neurones related to somatic sensation in rats.

The Effect of Anaesthetic Agents on Cerebral Cortical Responses in the Rat

Excitatory amino acid receptor‐mediated transmission of somatosensory evoked potentials in the rat thalamus.

Contact Info

Product

Resources

About