Processing of phosphocasein dispersions by dynamic high pressure: Effects on the dispersion physico-chemical characteristics and the binding of α-tocopherol acetate to casein micelles

Chevalier-Lucia, Dominique; Blayo, Claire; Gràcia-Julià, Alvar; Picart-Palmade, Laëtitia; Dumay, Eliane

doi:10.1016/j.ifset.2011.07.007

Cited by 46 publications

(23 citation statements)

References 51 publications

(76 reference statements)

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“…Lower viscosity was measured in UHPH treated samples of phospho-casein compared with samples without UHPH treatment by Chevalier-Lucia et al (2011), which agree with our results.…”

Section: Rheological Measurementssupporting

confidence: 92%

“…It also contained larger casein micelles (Chevalier-Lucia et al, 2011) and can be expected to have thicker electrical double layers surrounding the casein micelles due to higher ionic strength in the solution (Walstra, 2003). The subsequent rearrangement following UHPH treatment and the resulting microstructure formation will thus be different for the two samples and in samples with low mineral content probably a more diffuse network with more water protein interaction sites will be observed, hence the decreased relaxation time.…”

Section: Low Field Nuclear Magnetic Resonancementioning

confidence: 99%

“…Only few studies, all using piston-gap type homogenisers, have investigated the effect of UHPH treatment on the functional properties of whey protein-depleted or partial depleted milk concentrate solutions (Chevalier-Lucia, Blayo, Gr acia-Juli a, Picart-Palmade, & Dumay, 2011;Roach & Harte, 2008;Sørensen, Pedersen, Mortensen, & Ipsen, 2013). Roach and Harte (2008) described the changes in casein micelle size induced by different UHPH pressures (100,200,250,300 and 350 MPa) and levels of CaCl 2 (0, 5, 10 and 15 mM).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Dynamic ultra-high pressure homogenisation of whey protein-depleted milk concentrate

Sørensen

Mortensen

Sørland³

et al. 2015

International Dairy Journal

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“…Lower viscosity was measured in UHPH treated samples of phospho-casein compared with samples without UHPH treatment by Chevalier-Lucia et al (2011), which agree with our results.…”

Section: Rheological Measurementssupporting

confidence: 92%

Section: Low Field Nuclear Magnetic Resonancementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dynamic ultra-high pressure homogenisation of whey protein-depleted milk concentrate

Sørensen

Mortensen

Sørland³

et al. 2015

International Dairy Journal

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“…Among these, considerable interest in recent years has been shown in the use of carrier systems based on food proteins because they are comparatively inexpensive, widely available, non-toxic (Generally Recognized As Safe, GRAS), biodegradable, and have nutritional value and good sensory properties (7). Commonly used natural food proteins include albumin and gelatin (8); however, although this topic has recently retained attention, there is limited research regarding the use of milk proteins (e.g., whey protein and caseins).…”

Section: Introductionmentioning

confidence: 99%

“…The exposure of hydrophobic residues of the individual casein proteins during homogenization at ca. 300 MPa and micellar reassociation has shown to be an efficient method for the binding of hydrophobic compounds such as curcumin (20), triclosan (21), and α-tocopherol acetate (7). However, to the best of our knowledge, no studies on the effect of homogenization pressures higher than 400 MPa on the loading capacity of casein micelles were reported.…”

Section: Introductionmentioning

confidence: 99%

Effect of Ultra-High Pressure Homogenization on the Interaction Between Bovine Casein Micelles and Ritonavir

et al. 2014

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Purpose The aim of this work was to develop a milk-based powder formulation appropriate for pediatric delivery of ritonavir (RIT). Methods Ultra-high pressure homogenization (UHPH) at 0.1, 300 and 500 MPa was used to process a dispersion of pasteurized skim milk (SM) and ritonavir. Loading efficiency was determined by RP-HPLC-UV; characterization of RIT:SM systems was carried out by apparent average hydrodynamic diameter and rheological measurements as well as different analytical techniques including Trp fluorescence, UV spectroscopy, DSC, FTIR and SEM; and delivery capacity of casein micelles was determined by in vitro experiments promoting ritonavir release. Results Ritonavir interacted efficiently with milk proteins, especially, casein micelles, regardless of the processing pressure; however, results suggest that, at 0.1 MPa, ritonavir interacts with caseins at the micellar surface, whilst, at 300 and 500 MPa, ritonavir is integrated to the protein matrix during UHPH treatment. Likewise, in vitro experiments showed that ritonavir release from micellar casein systems is pH dependent; with a high retention of ritonavir during simulated gastric digestion and a rapid delivery under conditions simulating the small intestine environment. Conclusions Skim milk powder, especially, casein micelles are potentially suitable and efficient carrier systems to develop novel milk-based and low-ethanol powder formulations of ritonavir appropriate for pediatric applications.

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Development of casein‐based nanoencapsulation systems for delivery of epigallocatechin gallate and folic acid

Malekhosseini

Alami

Khomeiri

et al. 2019

Food Science & Nutrition

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In this work, binding characteristics of two hydrophilic nutraceutical models, namely epigallocatechin gallate (EGCG) and folic acid (FA), to sodium caseinate were studied by fluorimetry technique. EGCG‐loaded casein molecules were then converted to either re‐combined casein micelles (r‐CMs) or casein nanoparticles (CNPs). Binding stoichiometry of EGCG and FA was 0.81 and 1.02, respectively. As determined by DLS technique, the average particle size of r‐CMs prepared at 0.5% concentration was 66.2 nm. Thermal treatment (74°C, 20 s) had significant (p < 0.05) influence on the particle size of nanocarriers, but not nutraceutical loading. The average size of CNPs was larger than that of r‐CMs. The encapsulation efficiency (EE) of EGCG was 85%, and its ejection from the nanocarrier was less than 3% over 21 days. Alkaline conditions resulted in higher release of EGCG than acidic conditions. r‐CMs were more effective than CNPs during the protection of EGCG against heat‐induced degradation. TEM micrographs confirmed the formation of r‐CMs.

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Processing of phosphocasein dispersions by dynamic high pressure: Effects on the dispersion physico-chemical characteristics and the binding of α-tocopherol acetate to casein micelles

Cited by 46 publications

References 51 publications

Dynamic ultra-high pressure homogenisation of whey protein-depleted milk concentrate

Dynamic ultra-high pressure homogenisation of whey protein-depleted milk concentrate

Effect of Ultra-High Pressure Homogenization on the Interaction Between Bovine Casein Micelles and Ritonavir

Development of casein‐based nanoencapsulation systems for delivery of epigallocatechin gallate and folic acid

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