Processing of implicit versus explicit predictive contextual information in Parkinson's disease

Li, Ling; Diaz-Brage, Pablo; Fernández‐Lago, Helena; Fogelson, Noa

doi:10.1016/j.neuropsychologia.2017.12.006

Cited by 11 publications

(7 citation statements)

References 110 publications

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“…No significant P3a effect was observed between cue types in the explicit condition (t (13) ϭ 0.084, p ϭ 0.934, BF 10 ϭ 0.271). These results seem to corroborate previous findings demonstrating the influence of contextual processes on the P3, where P3 activity is modulated when the model or context of a stimulus environment needs to be updated (Donchin, 1981;Donchin and Coles, 1988;Polich and Kok, 1995;Todorovic et al, 2011;Seppänen et al, 2012;Silverstein et al, 2015;Bang and Rahnev, 2017;Li et al, 2018).…”

Section: Eeg Resultssupporting

confidence: 91%

Competitive Frontoparietal Interactions Mediate Implicit Inferences

Wokke

2019

J. Neurosci.

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Frequent experience with regularities in our environment allows us to use predictive information to guide our decision process. However, contingencies in our environment are not always explicitly present and sometimes need to be inferred. Heretofore, it remained unknown how predictive information guides decision-making when explicit knowledge is absent and how the brain shapes such implicit inferences. In the present experiment, 17 human participants (9 females) performed a discrimination task in which a target stimulus was preceded by a predictive cue. Critically, participants had no explicit knowledge that some of the cues signaled an upcoming target, allowing us to investigate how implicit inferences emerge and guide decision-making. Despite unawareness of the cue-target contingencies, participants were able to use implicit information to improve performance. Concurrent EEG recordings demonstrate that implicit inferences rely upon interactions between internally and externally oriented networks, whereby prefrontal regions inhibit parietal cortex under internal implicit control.

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Section: Eeg Resultssupporting

confidence: 91%

Competitive Frontoparietal Interactions Mediate Implicit Inferences

Wokke

2019

J. Neurosci.

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“…The VTA provides essentially normal levels of dopamine to the ventral striatum (VS), composed of the nucleus accumbens ventral caudate and putamen, as well as to the limbic (e.g., hippocampus) and prefrontal cortices. According to the dopamine overdose hypothesis, dopaminergic therapy, titrated to motor symptoms and hence DS dopamine deficiency, distributes in a non-targeted fashion, presumably overdosing VTA-innervated brain regions and worsening functions performed by these brain regions (Cools, 2006;Gotham et al, 1984;Kish et al, 1988;Macdonald and Monchi, 2011) The dopaminergic system has been implicated in processing regularities in sounds through its downstream projections, including areas of the prefrontal cortex (PFC) and hippocampus D'Ardenne et al, 2012;Li et al, 2018). Extrapolations from these studies notwithstanding, the effect of aging, PD, and dopaminergic medication on the fundamental process of regularity detection in sound is not well understood.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Aging, Parkinson’s Disease, and Exogenous Dopamine on the Neural Response Associated with Auditory Regularity Processing

Jaja¹,

Grahn²,

Herrmann³

et al. 2019

Preprint

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Processing regular patterns in auditory scenes is important for navigating complex environments. Electroencephalography (EEG) studies find enhancement of sustained brain activity, correlating with the emergence of a regular pattern in sounds. How aging, aging-related diseases such as Parkinson's disease (PD), and treatment of PD affect this fundamental function remain unknown. We addressed this knowledge gap. Healthy younger and older adults, and PD patients listened to sounds that contained or were devoid of regular patterns. Healthy older adults and PD patients were tested twice-on and off dopaminergic medication in counterbalanced order.Regularity-evoked, sustained EEG activity was reduced in older, compared to younger adults. PD patients and older controls had comparable attenuation of the sustained response. Dopaminergic therapy further weakened the sustained response in both groups. These findings suggest that fundamental regularity processing is impacted by aging-related neural changes but not those underlying PD. The finding that dopaminergic therapy attenuates rather than improves the sustained response coheres with the dopamine overdose response and implicates brain regions receiving dopamine from the ventral tegmental area in regularity processing.

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“…This was because high cluster coefficients and long path lengths are correlated with increased functional connections within the frontal loops, indicating less neurons/networks to support communications between the frontal and other cortical regions. Li 90 2018 OAP [58.1 (2.5)]; n = 17 OA [57 (2.6)]; n = 15 EEG Predictive sequence visual task OAP patients showed similar P3b amplitude across the implicit and explicit trials (when they were made aware of the predictive sequence and the subsequent target), whereas OA had higher P3b amplitudes for the explicit condition. OAP also exhibited longer P3b latencies for predicted targets compared to random targets in both the implicit and explicit sessions, indicating slower processing speed of predicted targets.…”

Section: Resultsmentioning

confidence: 99%

“…Three studies repeatedly showed that PD patients were able to detect targets but unable to utilize the contextual information (ie, a predictive sequence to help them generate a faster response in a subsequent trial). 25 , 89 , 90 Based on the authors’ interpretation, the extensive connections in PD patients’ frontal networks inhibited the rate at which information was relayed, hence the underperformance on the processing of contexts in this population. 89 , 90 Fogelson et al also compared CP performance involving PD and schizophrenic patients, and reported that both patient groups had abnormal network changes when processing context-dependent stimuli, specifically weaker frontal-temporal-parietal connections.…”

Section: Resultsmentioning

confidence: 99%

“… 25 , 89 , 90 Based on the authors’ interpretation, the extensive connections in PD patients’ frontal networks inhibited the rate at which information was relayed, hence the underperformance on the processing of contexts in this population. 89 , 90 Fogelson et al also compared CP performance involving PD and schizophrenic patients, and reported that both patient groups had abnormal network changes when processing context-dependent stimuli, specifically weaker frontal-temporal-parietal connections. 25 Interestingly, another study reported that proactive control was preserved amongst PD patients, as they showed the ability to adjust control mechanisms to better adapt to future response conflict.…”

Section: Resultsmentioning

confidence: 99%

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Contextual Processing and the Impacts of Aging and Neurodegeneration: A Scoping Review

Tran

McDonald

D’Arcy

et al. 2021

CIA

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Contextual processing (or context processing; CP) is an integral component of cognition. CP allows people to manage their thoughts and actions by adjusting to surroundings. CP involves the formation of an internal representation of context in relation to the environment, maintenance of this information over a period of time, and the updating of mental representations to reflect changes in the environment. Each of these functions can be affected by aging and associated conditions. Here, we introduced contextual processing research and summarized the literature studying the impact of normal aging and neurodegeneration-related cognitive decline on CP. Through searching the PubMed, PsycINFO, and Google Scholar databases, 23 studies were retrieved that focused on the impact of aging, mild cogniitve impairment (MCI), Alzheimer’s disease (AD), and Parkinson’s disease (PD) on CP. Results indicated that CP is particularly vulnerable to aging and neurodegeneration. Older adults had a delayed onset and reduced amplitude of electrophysiological response to information detection, comparison, and execution. MCI patients demonstrated clear signs of impaired CP compared to normal aging. The only study on AD suggested a decreased proactive control in AD participants in maintaining contextual information, but seemingly intact reactive control. Studies on PD restricted to non-demented older participants, who showed limited ability to use contextual information in cognitive and motor processes, exhibiting impaired reactive control but more or less intact proactive control. These data suggest that the decline in CP with age is further impacted by accelerated aging and neurodegeneration, providing insights for improving intervention strategies. This review highlights the need for increased attention to research this important but understudied field.

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Processing of implicit versus explicit predictive contextual information in Parkinson's disease

Cited by 11 publications

References 110 publications

Competitive Frontoparietal Interactions Mediate Implicit Inferences

Competitive Frontoparietal Interactions Mediate Implicit Inferences

The Effect of Aging, Parkinson’s Disease, and Exogenous Dopamine on the Neural Response Associated with Auditory Regularity Processing

Contextual Processing and the Impacts of Aging and Neurodegeneration: A Scoping Review

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