Processing and degradation behavior of porous magnesium scaffold for biomedical applications

Dutta, Swapan Kumar; Devi, K. Bavya; Roy, Mousumi

doi:10.1016/j.apt.2017.09.024

Cited by 40 publications

(30 citation statements)

References 31 publications

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“…[1][2][3] Mg is a relatively low-density metal which has remarkably similar properties to natural bone. The elastic modulus of Mg (40)(41)(42)(43)(44)(45) is well-matched with that of natural bone (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). This can in comparison to conventional metallic materials, minimize stress shielding effect leading to bone resorption and loosening of the implant.…”

Section: Introductionmentioning

confidence: 72%

“…Mg scaffolds with a precisely adjusted degree of porosity can provide appropriate mechanical support during bone healing. They can not only provide sufficient initial mechanical stability but also support good bone ingrowth, which is an important parameter to reach biological fixation . They can be served as templates for bone regeneration due to excellent biocompatibility and biodegradability.…”

Section: Introductionmentioning

confidence: 99%

“…They can not only provide sufficient initial mechanical stability but also support good bone ingrowth, which is an important parameter to reach biological fixation. [18][19][20] They can be served as templates for bone regeneration due to excellent biocompatibility and biodegradability. Despite all these advantages, the high corrosion rate of Mg specifically in chloride containing solutions such as body fluids limits clinical application of the porous Mg scaffolds.…”

Section: Introductionmentioning

confidence: 99%

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Corrosion behavior of porous magnesium coated by plasma electrolytic oxidation in simulated body fluid

Ghasemi

Kamrani

Hübler

et al. 2019

Materials & Corrosion

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Porous magnesium has a great potential to be used as degradable bone scaffolds. In this study, porous magnesium with 35% percolating porosity has been successfully fabricated through powder metallurgy route utilizing space holders. The intrinsic mechanical properties of the porous magnesium were measured by nanoindentation testing and analyzed with the Oliver–Pharr method. Afterward, a ceramic coating on the surface of the porous magnesium was performed by plasma electrolytic oxidation (PEO) treatment in a silicate‐based solution. The morphology and composition results of the PEO coatings indicated that it is possible to apply a homogenous and adhesive ceramic coating layer on all free surface of the porous magnesium through PEO method. The protective performance of the PEO coatings was evaluated using by potentiodynamic polarization and electrochemical impedance spectroscopy tests in simulated body fluid. The results revealed the PEO coating significantly improves biocorrosion resistance of the porous magnesium. Therefore, it can be used as an effective method to control the degradation rate of porous magnesium implants in the human body.

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Section: Introductionmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Corrosion behavior of porous magnesium coated by plasma electrolytic oxidation in simulated body fluid

Ghasemi

Kamrani

Hübler

et al. 2019

Materials & Corrosion

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“…They measured a <1-mm/year corrosion rate in a 0.9% NaCl solution at 37°C and larger osteoblastic cell proliferation for their material than for BMJ-printed porous Ti-only samples. Dutta and colleagues (147) reported that the degradation behavior of porous magnesium is controlled by the pore size, which can be engineered using AM. Kleger and colleagues demonstrated porous magnesium scaffolds via infiltration of DIW-printed salt templates (Figure 3a), showing replication of micrometer-sized features (55).…”

Section: Biodegradable Implants and Scaffoldsmentioning

confidence: 99%

Biomedical Applications of Metal 3D Printing

Velásquez–García

Kornbluth

2021

Annu. Rev. Biomed. Eng.

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Additive manufacturing's attributes include print customization, low per-unit cost for small- to mid-batch production, seamless interfacing with mainstream medical 3D imaging techniques, and feasibility to create free-form objects in materials that are biocompatible and biodegradable. Consequently, additive manufacturing is apposite for a wide range of biomedical applications including custom biocompatible implants that mimic the mechanical response of bone, biodegradable scaffolds with engineered degradation rate, medical surgical tools, and biomedical instrumentation. This review surveys the materials, 3D printing methods and technologies, and biomedical applications of metal 3D printing, providing a historical perspective while focusing on the state of the art. It then identifies a number of exciting directions of future growth: ( a) the improvement of mainstream additive manufacturing methods and associated feedstock; ( b) the exploration of mature, less utilized metal 3D printing techniques; ( c) the optimization of additively manufactured load-bearing structures via artificial intelligence; and ( d) the creation of monolithic, multimaterial, finely featured, multifunctional implants.

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“…In this scenario, very high-resolution morphological imaging methods, such as micro-computed tomography (CT), may play an important role. 15 – 17 This type of imaging is to be conserved complementary to the conventional in vivo radiological imaging, which in turn has a fundamental role in the management of patients needing long-term catheterization, both in the phase of first positioning 18 and at later times. 19…”

Section: Introductionmentioning

confidence: 99%

Comparative structural analysis of polyurethane and silicone catheters of totally implantable venous access devices by micro-computed tomography

et al. 2021

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Objectives: To investigate microstructural alterations of explanted long-term central venous catheters of totally implantable venous access devices, using micro-computed tomography. Methods: A total of 16 catheters (9 made of silicone and 7 made of polyurethane), all non-fractured, have been analyzed in this study. Eight catheters were implanted for an average duration of 994 days (min–max: 98–2731 days), while the remaining eight catheters (four for each material, forming the SIref and PUref control groups) were analyzed before implant and used as a reference. X-ray micro-computed tomography was used to reconstruct the three-dimensional geometry of selected segments of each catheter (ca. 10 cm per sample). Results: Morphometric analysis of the catheters revealed increases wall thickness and section area in the polyurethane group as compared with the reference central venous catheters of the same materials (wall thickness: 403 ± 12 μm in the polyurethane (PU) group vs 382 ± 4 μm in PUref, p = 0.014; wall cross-section area: 2.04 ± 0.09 mm2 in PU vs 1.91 ± 0.03 mm2 in PUref, p = 0.04), whereas implanted silicone catheters showed a larger luminal cross section as compared with their controls (lumen cross-section area = 0.851 ± 0.020 mm2 in silicone (SI) group vs 0.811 ± 0.007 mm2 in SIref, p = 0.007). All analyzed samples in this study presented some type of alteration in the catheter walls, namely, hyperdense spots (below 0.1 mm size), air gaps/bubbles and displacements of inner and outer axes causing heterogeneous wall thickness. The incidence of air gaps showed no difference with respect to both material type and duration of implant, whereas the SI group revealed more hyperdense spots as compared to all other groups. Conclusion: Morphological change and local structural alteration can occur in both silicone and polyurethane catheters. This evidence suggests the need for further studies connecting those morphological changes with modification of mechanical robustness, which ultimately can play a role for patient safety.

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Processing and degradation behavior of porous magnesium scaffold for biomedical applications

Cited by 40 publications

References 31 publications

Corrosion behavior of porous magnesium coated by plasma electrolytic oxidation in simulated body fluid

Corrosion behavior of porous magnesium coated by plasma electrolytic oxidation in simulated body fluid

Biomedical Applications of Metal 3D Printing

Comparative structural analysis of polyurethane and silicone catheters of totally implantable venous access devices by micro-computed tomography

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