Processing and coating of open-pored absorbable magnesium-based bone implants

Julmi, Stefan; Krüger, A.; Waselau, Anja‐Christina; Meyer‐Lindenberg, Andrea; Wriggers, Peter; Klose, Christian; Maier, Hans Jürgen

doi:10.1016/j.msec.2018.12.125

Cited by 41 publications

(54 citation statements)

References 39 publications

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“…For both alloys, the combined MgF 2 + PLA was the most effective coating for reducing the degradation rate. As demonstrated in an earlier study, 11 the mechanical properties of both Mg-La2 and LAE442 are sufficient for the typical scaffold application considered here. However, only coated LAE442 exhibited a degradation rate slow enough for the current context.…”

Section: In Vitro Degradation Of Mg Scaffoldsmentioning

confidence: 71%

“…A strong effect of grain size on the corrosion rate has been reported for LAE442, 11 thus the bottom and top parts of the scaffold degraded differently due to the different cooling rate and grain size there. By contrast, the Mg-La2 scaffold showed no pronounced difference in corrosion attack between the top and bottom (Fig.…”

Section: In Vitro Degradation Of Mg Scaffoldsmentioning

confidence: 91%

“…Details on the processing steps needed to form the top layers are given in Ref. 11. These coatings are designated hereinafter as MgF 2 , MgF 2 + CaP, and MgF 2 + PLA.…”

Section: In Vitro Degradationmentioning

confidence: 99%

“…The degradation behavior can be improved by alloying, adapting the microstructure, or application of coatings. 11,12 In vivo studies by Angrisani et al demonstrated a low in vivo degradation rate of dense scaffolds made of LAE442 alloy in a rabbit model. Part of the Mg scaffold was still present after 3.5 years.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, the resulting open-pored Mg scaffolds showed sufficient strength for the envisaged application. 11,16 Apparently, an ideal scaffold would promote bone ingrowth behavior, provide sufficient mechanical strength, and degrade after a given time without leaving any critical elements within the body. The objective of the present study is to move one step ahead in this direction by studying three different Mg-based alloys under conditions relevant for the clinical application.…”

Section: Introductionmentioning

confidence: 99%

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Magnesium Alloys for Open-Pored Bioresorbable Implants

Maier

Julmi

Behrens

et al. 2020

JOM

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If bone defects occur, the body's own healing mechanism can close them below a critical size; for larger defects, bone autografts are used. These are typically cut from the same person's hip in a second surgery. Consequently, the risk of complications, such as inflammations, rises. To avoid the risks resulting from the second surgery, absorbable, open-pored implants can be used. In the present study, the suitability of different magnesium alloys as absorbable porous bone substitute material has been investigated. Using the investment casting process with its design flexibility, the implant's structure can be adapted to the ideal pore geometry with respect to bone ingrowth behavior. Different magnesium alloys (Mg-La2, LAE442, and ZX61) were studied and rated in terms of their degradation rate, bone ingrowth behavior, biocompatibility, and resorbability of the individual alloying elements.

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Section: In Vitro Degradation Of Mg Scaffoldsmentioning

confidence: 71%

Section: In Vitro Degradation Of Mg Scaffoldsmentioning

confidence: 91%

“…Details on the processing steps needed to form the top layers are given in Ref. 11. These coatings are designated hereinafter as MgF 2 , MgF 2 + CaP, and MgF 2 + PLA.…”

Section: In Vitro Degradationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Magnesium Alloys for Open-Pored Bioresorbable Implants

Maier

Julmi

Behrens

et al. 2020

JOM

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Comparison of two pore sizes of LAE442 scaffolds and their effect on degradation and osseointegration behavior in the rabbit model

et al. 2020

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The magnesium alloy LAE442 emerged as a possible bioresorbable bone substitute over a decade ago. In the present study, using the investment casting process, scaffolds of the Magnesium (Mg) alloy LAE442 with two different and defined pore sizes, which had on average a diameter of 400 μm (p400) and 500 μm (p500), were investigated to evaluate degradation and osseointegration in comparison to a ß‐TCP control group. Open‐pored scaffolds were implanted in both greater trochanter of rabbits. Ten scaffolds per time group (6, 12, 24, and 36 weeks) and type were analyzed by clinical, radiographic and μ‐CT examinations (2D and 3D). None of the scaffolds caused adverse reactions. LAE442 p400 and p500 developed moderate gas accumulation due to the Mg associated in vivo corrosion, which decreased from week 20 for both pore sizes. After 36 weeks, p400 and p500 showed volume decreases of 15.9 and 11.1%, respectively, with homogeneous degradation, whereas ß‐TCP lost 74.6% of its initial volume. Compared to p400, osseointegration for p500 was significantly better at week 2 postsurgery due to more frequent bone‐scaffold contacts, higher number of trabeculae and higher bone volume in the surrounding area. No further significant differences between the two pore sizes became apparent. However, p500 was close to the values of ß‐TCP in terms of bone volume and trabecular number in the scaffold environment, suggesting better osseointegration for the larger pore size.

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Biomaterials for orthopedic applications and techniques to improve corrosion resistance and mechanical properties for magnesium alloy: a review

et al. 2023

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The present study aims to collect data, compare results and assess techniques used for improving corrosion resistance and mechanical properties of biodegradable Mg alloys for fixation elements and orthopedic applications. A general description of biomaterials used for orthopedic implants is performed, including non-bioabsorbable materials. Different methods for reducing the corrosion rate in Mg alloys are researched, and the efficiencies are assessed. After evaluating different techniques, surface modification is found to be the most promising technique to reduce the corrosion rate with an efficiency of 85%. Regarding the Mg alloying agents, Zn is considered as the best candidate to improve the corrosion response and biocompatibility of the Mg.

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Processing and coating of open-pored absorbable magnesium-based bone implants

Cited by 41 publications

References 39 publications

Magnesium Alloys for Open-Pored Bioresorbable Implants

Magnesium Alloys for Open-Pored Bioresorbable Implants

Comparison of two pore sizes of LAE442 scaffolds and their effect on degradation and osseointegration behavior in the rabbit model

Biomaterials for orthopedic applications and techniques to improve corrosion resistance and mechanical properties for magnesium alloy: a review

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