Processing and characterization of novel borophosphate glasses and fibers for medical applications

Massera, Jonathan; Shpotyuk, Yaroslav; Sabatier, Fantine; Jouan, Thierry; Boussard‐Plédel, Catherine; Roiland, Claire; Bureau, Bruno; Petit, Laëticia; Boetti, Nadia Giovanna; Milanese, Daniel; Hupa, Leena

doi:10.1016/j.jnoncrysol.2015.05.028

Cited by 46 publications

(25 citation statements)

References 39 publications

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“…However, the changes in pH were much less pronounced compared to the glasses investigated in (Massera, Vassallo‐Breillot, et al, ; Mishra et al, , ). This is attributed to the B 2 O 3 substitution for P 2 O 5, which leads to enhanced hydrolytic resistance (Massera et al, ; Sharmin et al, ).…”

Section: Discussionmentioning

confidence: 99%

In‐vitro dissolution characteristics and human adipose stem cell response to novel borophosphate glasses

Mishra

Ojansivu

Autio

et al. 2019

J Biomedical Materials Res

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The main drawbacks of traditional silicate bioactive glasses are their narrow hot forming domain and noncongruent dissolution. In this article, we report on new borophosphate glasses [xMnOm + (100 − x) (47.5P2O5 + 2.5B2O3 + 10Na2O + 20CaO + 20SrO)], MnOm being CuO, Ag2O, and CeO2, having high thermal processability, hence suitable for fiber drawing and sintering into scaffolds. Furthermore, the glasses dissolve congruently in simulated body fluid (SBF) and TRIS buffer solution, eventually leading to the precipitation of a reactive layer. Human adipose stem cells (hASC) were cultured in media enriched with glass extract at different dilutions, to investigate the optimal ion concentration for cell survival. Cells grew in all the extracts, except in the undiluted Cu‐doped glass extract. At dilution 1:10, the lactate dehydrogenase (LDH) activity and cell proliferation were comparable to the control, while at 1:100, the cells proliferated faster than the control. Thus, the reference (undoped), Ag and Ce‐doped glasses were found to be suitable for cell viability and proliferation. Cytotoxicity assessments using the LDH assay indeed revealed the high cytotoxicity of the Cu extract. This raises questions about the use of Cu in bioactive glasses and its optimal concentration as a dopant.

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Section: Discussionmentioning

confidence: 99%

In‐vitro dissolution characteristics and human adipose stem cell response to novel borophosphate glasses

Mishra

Ojansivu

Autio

et al. 2019

J Biomedical Materials Res

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“…30 A schematic of the drawing tower can be found in. 30 A schematic of the drawing tower can be found in.…”

Section: Preform Preparation and Fiber Drawingmentioning

confidence: 99%

“…The resulting core-clad preform was drawn by using the rod-in-tube method in a specially designed 2 m high drawing tower as described in. 30 A schematic of the drawing tower can be found in. 35 To reduce the moisture concentration, the system was purged with Ar gas laminar flow at the rate of 3 L/min before the drawing.…”

Section: Preform Preparation and Fiber Drawingmentioning

confidence: 99%

“…20,21 In addition, phosphate glasses with P 2 O 5 higher than 45 mol% have proven to be easily drawable into optical fibers. 24,30 Recently, optical fibers have gained a lot of interest for use in biomedical applications such as phototherapy, optogenetics, biological sensing, and imaging. 14,20,21,28,29 However, to the best of our knowledge, only few studies focusing on glass compositions that combine both biocompatibility and suitable optical properties have been reported up to now.…”

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confidence: 99%

“…14,20,21,28,29 However, to the best of our knowledge, only few studies focusing on glass compositions that combine both biocompatibility and suitable optical properties have been reported up to now. 24,30 Recently, optical fibers have gained a lot of interest for use in biomedical applications such as phototherapy, optogenetics, biological sensing, and imaging. 31 Noticeable research efforts are spent in the development of biodegradable or bioactive optical fibers, which can be resorbed or can lead to new soft tissue once the therapeutic or sensing utility has been accomplished so that the surgical removal of the fiber sensor is not needed.…”

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confidence: 99%

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Design, processing, and characterization of an optical core‐bioactive clad phosphate fiber for biomedical applications

et al. 2019

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The aim of this study was to fabricate a bioactive optical fiber able to monitor “in situ” its reaction with the body through changes in its optical properties. Core and cladding preforms were prepared with the composition (97.25*(0.50P2O5‐0.40SrO‐0.10Na2O)‐2.5ZnO‐0.25Er2O3) and (98.25*(0.50P2O5‐0.40SrO‐0.10Na2O)‐1.75ZnO) (in mol%), respectively, and successfully drawn into a multimode core/clad optical fiber. Optical and near‐Infrared images assessed the proper light guiding properties of the fiber. The fibers favor the precipitation of a Ca‐P reactive layer at its surface concomitant with a reduction in the fiber diameter, when immersed in SBF, often assigned as a sign of bioactivity. It is clearly shown here that the bio‐response of the fiber upon immersion in SBF can be tracked from the decrease in the intensity of the Er3+ ions emission at 1.5 µm. This confirms that the newly developed optical fiber, which combines good optical properties with a suitable bioactive behavior, is a promising platform for the development of novel biomedical devices for biophotonic and photomedical applications. Finally, the successful splicing of the newly developed fiber with commercial optical fibers was an evidence of the possibility to integrate the newly developed phosphate fiber within existing components used in the field of biomedicine.

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Structural and Optical Study of CoO Doping in Borophosphate Host Glass and Effect of Gamma Irradiation

Fayad

Shaaban

Abd-Allah

et al. 2020

J Inorg Organomet Polym

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Processing and characterization of novel borophosphate glasses and fibers for medical applications

Cited by 46 publications

References 39 publications

In‐vitro dissolution characteristics and human adipose stem cell response to novel borophosphate glasses

In‐vitro dissolution characteristics and human adipose stem cell response to novel borophosphate glasses

Design, processing, and characterization of an optical core‐bioactive clad phosphate fiber for biomedical applications

Structural and Optical Study of CoO Doping in Borophosphate Host Glass and Effect of Gamma Irradiation

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