Processes and Data Management of Computer-Aided Sperm Analysis in Human and Animal Spermatozoa

Horst, Gerhard van der

doi:10.1007/978-3-030-66292-9_27

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…There are an increasing number of advanced examinations for sperm, 8 15 comprising tests such as DNA quality and fragmentation, 16 17 multiparametric sperm assessment, 18 and computer-aided sperm analysis. 19 20 21 There have been several calls for some of these examinations, most notably DNA fragmentation, to become part of standard sperm analysis. However, we believe that there is a way to go before these assessments reach the thresholds required to be considered as routine.…”

Section: Before Treatment—optimize the Manmentioning

confidence: 99%

Only the Best of the Bunch—Sperm Preparation Is Not Just about Numbers

Gallagher,

Krasauskaite,

Kirkman-Brown

2023

Semin Reprod Med

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In this Seminar, we present an overview of the current and emerging methods and technologies for optimizing the man and the sperm sample for fertility treatment. We argue that sperms are the secret to success, and that there are many avenues for improving both treatment and basic understanding of their role in outcomes. These outcomes encompass not just whether treatment is successful or not, but the wider intergenerational health of the offspring. We discuss outstanding challenges and opportunities of new technologies such as microfluidics and artificial intelligence, including potential pitfalls and advantages. This article aims to provide a comprehensive overview of the importance of sperm in fertility treatment and suggests future directions for research and innovation.

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Section: Before Treatment—optimize the Manmentioning

confidence: 99%

Only the Best of the Bunch—Sperm Preparation Is Not Just about Numbers

Gallagher,

Krasauskaite,

Kirkman-Brown

2023

Semin Reprod Med

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Systematic approaches to assessing high-temperature limits to fertility in animals

Bretman,

Fricke,

Baur

et al. 2024

Journal of Evolutionary Biology

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Critical Thermal Limits (CTLs) gauge the physiological impact of temperature on survival or critical biological function, aiding predictions of species range shifts and climatic resilience. Two recent Drosophila species studies, using similar approaches to determine temperatures that induce sterility (Thermal Fertility Limits; TFLs), reveal that TFLs are often lower than CTLs, and that TFLs better predict both current species distributions and extinction probability. Moreover, many studies show fertility is more sensitive at less extreme temperatures than survival (Thermal Sensitivity of Fertility: TSF). These results present a more pessimistic outlook on climate change consequences. However, unlike CTLs, TFL data are limited to Drosophila, and variability in TSF methods pose challenges in predicting species responses to increasing temperature. To address these data and methodological gaps, we propose three standardised approaches for assessing thermal impacts on fertility. We focus on adult obligate sexual terrestrial invertebrates, but also provide modifications for other animal groups and life history stages. We first outline a “gold-standard” protocol for determining TFLs, focusing on the effects of short-term heat shocks, simulating more frequent extreme heat events predicted by climate models. As this approach may be difficult to apply to some organisms, we then provide a standardised TSF protocol. Finally, we provide a framework to quantify fertility loss in response to extreme heat events in nature, given limitation in laboratory approaches. Applying these standardised approaches across many taxa, similar to CTLs, will allow robust tests of the impact of fertility loss on species responses to increasing temperatures.

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Processes and Data Management of Computer-Aided Sperm Analysis in Human and Animal Spermatozoa

Cited by 2 publications

References 10 publications

Only the Best of the Bunch—Sperm Preparation Is Not Just about Numbers

Only the Best of the Bunch—Sperm Preparation Is Not Just about Numbers

Systematic approaches to assessing high-temperature limits to fertility in animals

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