Process Simulation of Twin‐Screw Granulator: Effect of Screw Configuration on Size Distribution

Abstract

The effect of screw configuration on granule size distribution (GSD) using gPROMS FormulatedProduct (gFP) software to perform optimization, estimation of complex processes, and analyses is evaluated. Twin‐screw granulation modeling was used to investigate the contribution of screw configuration and liquid‐to‐solid (L/S) ratio on GSD. Lactose and Avicel were the granulating materials. Twelve different configurations were investigated under three feed rates as consistent with literature and at various L/S ratios. Results indicate that kneading elements promote the recovery of 100–1000 µm granules while reducing the production of oversized granules. Higher feed rates support the production of fines and agglomerates, while a low feed rate produces 100–1000 µm granules.

Process Simulation of Twin-Screw Granulation: A Review

“…The PBM, in either its one-dimensional or multi-dimensional form, has been utilised to forecast the progressive alterations in granule characteristics, including granule size distribution, moisture content, density, and porosity [ 6 ]. Equation (1) represents the general equation for the PBM, Equation (2) illustrates the concept of particles in a specific region of the particle phase, and Equation (3) provides a generic depiction of the super-structure of the PBM [ 53 ]. where is the particle velocity, is the number of density particles, with the particles’ birth rate and death rate being , respectively.…”