Process parameter and kinetic study for the azidation of a zidovudine intermediate with sodium azide in microreactors

Revisiting aromatic diazotization and aryl diazonium salts in continuous flow: highlighted research during 2001–2021

“…Through the analysis of the accurate and effective kinetic model, the influence of parameters on the main reaction can be well predicted, so as to obtain the reaction conditions corresponding to the best selectivity and yield. 107–109…”

“…Through the analysis of the accurate and effective kinetic model, the influence of parameters on the main reaction can be well predicted, so as to obtain the reaction conditions corresponding to the best selectivity and yield. [107][108][109] Non-isothermal models using nondimensional numbers (ratio of relative time scales), such as mixing (Da M ), reaction time (Da RM , Da RS ), and heat transfer (Q), can be used to study the effects of parameters and variables such as temperature, molar ratio, Da RM /Da RS , and activation energy. The variable Da RM /Da RS , the ratio of the time scale of the main and side reactions, clearly reflects the influence of the system on selectivity.…”

On-Demand Production of Two Commercial Plant Activators, Tiadinil and Methiadinil, under an Integrated Continuous Flow System

“…Among them, a Baker's type 3D chip (Figure S1 in the Supporting Information) exhibited excellent mixing efficiency 29,30 and has been successfully used in the continuous synthesis of quinuclidine. 31 Taking advantage of Cheng's reaction chips in efficiency and flexibility, we set up an integrated continuous flow system and reported herein its application to the multistep synthesis of tiadinil and methiadinil.…”

Fully Continuous Flow Synthesis of 2′-Deoxy-2′-fluoro-arabinoside: A Key Intermediate of Azvudine

“…Other benefits are a confined reaction system and strong pressure resistance . Hence, it has the advantages of intrinsic safety, , precise control, and rapid scale-up. , It is well–known that these benefits have been demonstrated with good effect on fast and strong exothermic reactions, such as nitration and hydrogenation, , toxic and harmful reactions, such as chlorination and fluorination, dangerous and explosive reactions, such as azide oxidation and some extreme conditions. , Therefore, microreactor technology has been widely used in the fine chemical industry, life science and preparation of nanoparticles, − and pharmaceutical continuous manufacturing, which are increasingly moving toward green and intelligent development …”