Process optimization of dry granulation based tableting line: Extracting physical material characteristics from granules, ribbons and tablets using near-IR (NIR) spectroscopic measurement

Khorasani, Milad; Amigo, José Manuel; Bertelsen, Poul; Sun, Changquan Calvin; Rantanen, Jukka

doi:10.1016/j.powtec.2016.03.004

Cited by 33 publications

(21 citation statements)

References 22 publications

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“…However, in the 21 st century roller compaction has attracted renewed scientific attention, especially due to the transition of equipment from manual to automatic that resulted in a higher level of process control (Guigon et al, 2007;Khorasani et al, 2016;Miller 2005;Osborne et al, 2013). Similarly to hot-melt coating, roller compaction is a solvent-free technology resulting in a fast and cost-effective manufacturing process, since timeconsuming evaporation steps or costly solvent recovery and disposal are not required (Guigon et al, 2007;Jannin & Cuppok, 2013;Jozwiakowski et al, 1990;Miller 2005).…”

Section: Introductionmentioning

confidence: 99%

Improving the granule strength of roller-compacted ibuprofen sodium for hot-melt coating processing

Lopes

Garsuch

Becker

et al. 2016

International Journal of Pharmaceutics

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Section: Introductionmentioning

confidence: 99%

Improving the granule strength of roller-compacted ibuprofen sodium for hot-melt coating processing

Lopes

Garsuch

Becker

et al. 2016

International Journal of Pharmaceutics

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“…These methods can be either pattern recognition (such as principal component analysis, PCA), classification methods (such as linear discriminant analysis, LDA), or calibration methods (such as multivariate curve resolution, MCR). 12 There are some examples of application of NIR-CI [13][14][15][16][17] in the pharmaceutical area, with very promising results. Acetylsalicylic acid (ASA) concentration maps on commercial tablet samples were obtained by MCR without a previous calibration step.…”

Section: Introductionmentioning

confidence: 99%

Optimization of Experimental Parameters in Analysis of Pharmaceutical Pellets by Near Infrared-Chemical Imaging (NIR-CI) and Multivariate Curve Resolution with Alternating Least Squares (MCR-ALS)

Da-Col¹,

Poppi²

2018

J. Braz. Chem. Soc.

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The quality control of pellets homogeneity cannot be assessed by conventional techniques and near infrared-chemical imaging combined with multivariate curve resolution with alternating least squares is an attractive alternative. In this study, composition and spatial distribution of pellets components were determined after assessment of experimental parameters. The use of a 25 μm intermediate pixel size, an initial estimation matrix with instrumental signals for pure substances and individual matrices provided a model with explained variance of more than 99% and a value of 0.00263 for percentage of lack of fit. In addition, the similarity between the pure substances spectra and those recovered by the model were 0.9501 for sucrose, 0.9480 for starch, 0.9910 for ketoprofen and 0.5941 for SiO 2 . Chemical images were generated and show that the pellet is composed of an inert nucleus of starch and cellulose, surrounded by a ketoprofen layer. All this information was obtained quickly, in minutes, being an excellent alternative for pellets analysis.

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“…The differences in the mechanisms are also found in wet [8] and dry granulation [9]. The process of wet granulation improves the powder properties by the coalescence of agitated primary particles with a liquid binder, to enlarge the particle size [10].…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric analysis of disintegration mechanisms (abrasion and crushing) of agglomerates during the disc granulation of dolomite

Obraniak

Ławińska²

2017

Granular Matter

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The analysis of mechanisms which affect the formation of agglomerates and determine the granulation process in a broad sense encounters difficulties related to the many ways of the formation of granules. The aim of the study was to perform a qualitative and quantitative analysis of granulation mechanisms with special reference to agglomerates' disintegration in the disc granulation process. This paper contains an analysis of disintegration mechanisms (abrasion and crushing) of agglomerates during the disc granulation of dolomite. The analysis of the mechanisms taking place during the process concerns the granulation stage after wetting. During the research, each time after the wetting stage, the size fraction 10-12.5 mm was substituted with an analogous fraction wetted by means of an aqueous solution of a coloring agent and the process was continued. After the specified time of granulation, the obtained product was sieved through laboratory sieves and then the content of the provided coloring agent in different size fractions was analyzed by means of a spectrophotometer. Measuring the absorbance of the analyzed samples and granulometric composition of the bed, the level and cause of the migration of material of the tested fraction into other size classes were determined, and at the same time, the occurring granulation mechanisms were analyzed. The proposed model and measurement method consisting of determining the absorbance of the tested granulometric fraction enable the qualitative and quantitative analysis of granulation mechanisms are encountered during the carrying-out of the process after wetting the bed.

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Process optimization of dry granulation based tableting line: Extracting physical material characteristics from granules, ribbons and tablets using near-IR (NIR) spectroscopic measurement

Cited by 33 publications

References 22 publications

Improving the granule strength of roller-compacted ibuprofen sodium for hot-melt coating processing

Improving the granule strength of roller-compacted ibuprofen sodium for hot-melt coating processing

Optimization of Experimental Parameters in Analysis of Pharmaceutical Pellets by Near Infrared-Chemical Imaging (NIR-CI) and Multivariate Curve Resolution with Alternating Least Squares (MCR-ALS)

Spectrophotometric analysis of disintegration mechanisms (abrasion and crushing) of agglomerates during the disc granulation of dolomite

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