Process Intensification of Tetrazole reaction through tritylation of 5-[4′-(Methyl) Biphenyl-2-Yl] using microreactors

Maralla, Yadagiri; Sonawane, Shirish H.; Kashinath, Dhurke; Pimplapure, Makarand S.; Paplal, Banoth

doi:10.1016/j.cep.2016.12.003

Cited by 13 publications

(3 citation statements)

References 23 publications

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“…While the diameter of a microreactor decreases it leads to increase the bombardment among the particles, which enhances the mixing of the reactants. This will decreases diffusion path length which leads increase in reaction rate and finally it attain the equilibrium in small time for reversible reactions [34].…”

Section: Effect Of Radius Of Curvature Of the Helical Capillary Micromentioning

confidence: 99%

“…Helical capillary microstructured reactor with bends/ turns have been planned for continuous flow applications as it provides well residence time distributions (RTD), enhanced heat as well as mass transfer in laminar stream/regimes for the residence times up to few minutes/ seconds based on the reaction type [27][28][29][30][31][32][33][34]. As the diameter of a microreactor increases, it decreases the bombardment among the particles, which leads to ineffective mixing and increase in diffusion path length.…”

Section: Effect Of Radius Of Curvature Of the Helical Capillary Micromentioning

confidence: 99%

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Process Intensification by Using a Helical Capillary Microreactor for a Continuous Flow Synthesis of Peroxypropionic Acid and Its Kinetic Study

Maralla

Sonawane

2019

Period. Polytech. Chem. Eng.

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Peroxypropionic acid (PPA) is an important organic chemical compound. Due to its versatile oxidizing properties, it is used in the oil, chemical and other industries. In this article, an attempt was made for the production of PPA in a Teflon helical capillary microreactor without and with homogeneous catalyst. The article reports the perhydrolysis of PPA with the effect of various parameters such as concentration of hydrogen peroxide, molar ratio of reactants, radius of curvature of the microreactor, concentration of catalyst and temperature. The reaction is slow, as the PPA equilibrium was found to be reached within 10 min at a temperature of 50 °C and at 10 mol % catalyst loading based on propionic acid. The reaction was carried out in 13.25 and 23.25 mm radius of curvature of the microreactor in which 4.0375 and 3.488 mol/L concentrations of PPA respectively were obtained at 50 ºC and 10 mol % catalyst. It indicates that as radius of curvature decreases, better mixing was provided among the reactants for the reaction to give enhanced yield and selectivity. From the experimental data and the kinetic expressions, the expressions of activation energies and reaction rate constants were determined. For PPA synthesis and hydrolysis, the activation energies were 43.897 and 20.658 kJ/mol respectively without catalyst, while the activation energies for both the cases were 42.314 and 17.514 kJ/mol respectively with catalyst of 10 mol% based on propionic acid. The dean number, curve tube friction factor and pressure drop also determined for the helical capillary microreactor.

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Section: Effect Of Radius Of Curvature Of the Helical Capillary Micromentioning

confidence: 99%

Section: Effect Of Radius Of Curvature Of the Helical Capillary Micromentioning

confidence: 99%

Process Intensification by Using a Helical Capillary Microreactor for a Continuous Flow Synthesis of Peroxypropionic Acid and Its Kinetic Study

Maralla

Sonawane

2019

Period. Polytech. Chem. Eng.

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“…In recent years, continuous flow chemistry technology has undergone rapid developments. As a new type of reactor, microchannel reactors have unique advantages in reducing energy consumption, improving mass and heat transfer, inhibiting parallel side reactions and improving the safety of reaction systems. , These characteristics have led to the widespread adoption of microchannel continuous flow technology in drug synthesis, the fine chemical industry, biochemistry, and other related fields. Microchannel continuous flow technology is capable of handling a variety of hazardous processes, − with particular interest revolving around the continuous synthesis of diazo compounds in the realm of modern synthetic chemistry.…”

Section: Introductionmentioning

confidence: 99%

Continuous Flow Synthesis of Ethyl Diazoacetate and CFD Analysis of Micromixing Efficiency in a Microreactor

Wang,

Zhou,

Zhang

et al. 2024

Ind. Eng. Chem. Res.

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Flow chemistry coupled with microreactor technology represents a contemporary advancement in the chemical industry. This approach integrates chemical synthesis, organic chemistry, and green chemistry, offering enhanced safety for hazardous chemical operations. In the present study, the continuous flow synthesis and separation of diazoacetate ethyl ester (EDA) in a microchannel reactor were investigated using glycine ethyl ester hydrochloride (GEE), sodium nitrite, and acetic acid as starting materials, with 1,2-dichloroethane utilized as an extractant. Response surface analysis (RSM) was adopted to determine appropriate test design factors and levels using singlefactor experiments as a basis, and a model was constructed by means of the Box−Behnken Design (BBD) central combination principle. The effects of reaction temperature (5−15 °C), GEE to acetic acid molar ratio (1: 2.8−3.2), residence time (90−150 s), and GEE to sodium nitrite molar ratio (1: 1.0−1.2) were investigated, examining the interactions among these factors to determine their combined effects on the yield of the diazotization process. The optimal process conditions for synthesizing ethyl diazoacetate in a microchannel reactor were determined: n(GEE):n(sodium nitrite):n(acetic acid) = 1:1.154:3.069, reaction temperature of 9.82 °C, and residence time of 135.18 s. The yield of GEE diazonium salt under such conditions was predicted to be 95.02%. The results reveal that the residence time significantly affected the yield of the product. Additionally, a three-dimensional computational fluid dynamics model was developed for the microchannel reactor to predict flow patterns and micromixing efficiency during the iodate− iodide reaction. As demonstrated, velocity, path lines, and concentration distributions inside the reactor could be visualized by examining the effects of Re, volumetric flow ratio (R), and initial H + concentration on micromixing efficiency (representative of the segregation index X S ). X S decreased with increasing Re or decreasing R or initial H + concentrations. The control system for the integrated continuous flow preparation of EDA, which integrates continuous production, extraction, and separation, provides a novel approach for industrial production.

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Hydrodynamic, Mass Transfer and RTD Studies of Fluid Flow in a Spiral Microreactor

Bhivgade

Maralla

Bhanvase

et al. 2019

J. Inst. Eng. India Ser. E

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Process Intensification of Tetrazole reaction through tritylation of 5-[4′-(Methyl) Biphenyl-2-Yl] using microreactors

Cited by 13 publications

References 23 publications

Process Intensification by Using a Helical Capillary Microreactor for a Continuous Flow Synthesis of Peroxypropionic Acid and Its Kinetic Study

Process Intensification by Using a Helical Capillary Microreactor for a Continuous Flow Synthesis of Peroxypropionic Acid and Its Kinetic Study

Continuous Flow Synthesis of Ethyl Diazoacetate and CFD Analysis of Micromixing Efficiency in a Microreactor

Hydrodynamic, Mass Transfer and RTD Studies of Fluid Flow in a Spiral Microreactor

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