Process Development and Manufacturing: CELL THERAPY MANUFACTURING PROCESS ANALYTICAL UTILITY OF RAMAN SPECTROSCOPY

Biomedical applications, perspectives and tag design concepts in the cell – silent Raman window

“…Raman spectroscopy is one of them as it is able to reveal molecular bond vibrations in samples of interest through the analysis of the inelastic (Raman scattered) light resulting from its interaction with the sample. Those sample-specific molecular fingerprints which can be acquired in a non-invasive way, led to the employment of Raman spectroscopy in different fields such as pharmaceutics, 1 regenerative medicine, 2 pathogen identification, 3,4 environment and food analysis, 5–7 art, 8 forensics, 9 body fluid analysis, 10–13 cell therapies, 14,15 cancer screening 16 and other disease diagnosis. 17–20…”

“…analysis of the inelastic (Raman scattered) light resulting from its interaction with the sample. Those sample-specific molecular fingerprints which can be acquired in a non-invasive way, led to the employment of Raman spectroscopy in different fields such as pharmaceutics, 1 regenerative medicine, 2 pathogen identification, 3,4 environment and food analysis, [5][6][7] art, 8 forensics, 9 body fluid analysis, [10][11][12][13] cell therapies, 14,15 cancer screening 16 and other disease diagnosis. [17][18][19][20] However, the application of spontaneous Raman spectroscopy on biological samples suffers from (a) inherently weak signal-to-noise ratio and (b) low concentration of the analytes of interest.…”