Process control with compact NMR

Strangers in the Night—Smart Process Sensors in Our Current Automation Landscape

“…Quantitative online nuclear magnetic resonance (NMR) spectroscopy has a high potential for direct loop process control of fluid process streams [1,3] since it provides rapid and non-invasive information when applied in a flow through mode. One of the most attractive features of quantitative NMR spectroscopy is that NMR peak areas can be directly used for concentration quantification without further calibration-if complete spin magnetisation is achieved.…”

“…[1] The developed smart NMR sensor is provided in an explosion proof housing (Figure 2b) involves a compact 43.5 MHz NMR spectrometer together with an acquisition unit and a programmable logic controller for fully automated data preparation (phasing, baseline correction) and quantitative evaluation. Therefore, a spectral modeling procedure based on Indirect Hard Modeling (IHM) was developed and validated for data analysis of the low-field NMR spectra.…”

“…It can be easily transferred to manufacturing for process control and for quality assurance of final products to meet required product specifications, since it provides dynamic information about product properties, material stream characteristics, and process conditions [1].…”

Application of green analytical chemistry to a green chemistry process: Magnetic resonance and Raman spectroscopic process monitoring of continuous ethanolic fermentation

“…Compact spectrometers, that is, small‐dimension analyzers, are flexible, robust and today available for a wide range of applications (Blümich, ; Blümich & Singh, ; Danieli et al, ; Kern et al, ; Killner, Garro Linck, Danieli, Rohwedder, & Blümich, ; Kreyenschulte, Paciok, Regestein, Blümich, & Büchs, ; Meyer, Kern, Zientek, Guthausen, & Maiwald, ; Singh, Danieli, & Blümich, ). Automated analyses should be performed preferably without sample preparation and in real time (Maiwald et al, ; Meyer et al, ; Rathore, Bhushan, & Hadpe, ; Rosas, Blanco, González, & Alcalà, ; Singh et al, ; Sugimoto, Fukuyama, Sumino, Takagi, & Ryu, ). Through an equally automated data analysis, the raw data may be received, centrally stored and converted into meaningful and applicable plots or diagrams such as concentration–time ( c–t ) diagrams (Jaeger & Legner, ; Wu, Li, & Gao, ).…”

Monitoring of hydrogenation by benchtop NMR with parahydrogen‐induced polarization

“…Although the use of real‐time NMR for monitoring reactions in situ is in its infancy by using a portable NMR spectrometer in the field, the trend is rapidly changing with technological improvements to make it increasingly practical. The NMR technique has gained particular research interest in pharmaceutical and chemical industries because it can be easily applied to the manufacturing system for chemical process control and for quality check of products to meet target specifications . This is an emerging approach that provides specific bonding and structural information.…”