Process analytical technology tools for process control of roller compaction in solid pharmaceuticals manufacturing

Abstract

This article presents an overview of using process analytical technology in monitoring the roller compaction process. In the past two decades, near-infrared spectroscopy, near-infrared spectroscopy coupled with chemical imaging, microwave resonance technology, thermal effusivity and various particle imaging techniques have been used for developing at-, off-, on- and in-line models for predicting critical quality attributes of ribbons and subsequent granules and tablets. The common goal of all these methods is improved process understanding and process control, and thus improved production of high-quality products. This article reviews the work of several researchers in this field, comparing and critically evaluating their achievements.

Granulation process analysis technologies and potential applications in traditional Chinese medicine

“…Near-infrared spectroscopy (NIRS), near-infrared chemical imaging (NIR-CI), microwave resonance technology (MRT), thermal effusivity, and various imaging techniques have been used in off-line, at-line, on-line, and in-line modes to predict the CQAs of rolled belts and subsequent manufactured granules and tablets. The common goal of all these technologies is to improve granulation process understanding and control, and increase the output of high-quality products [17] .…”