Process Alternatives for Coupling Reaction and Distillation

Gadewar, Sagar B.; Tao, Ling; Malone, Michael F.; Doherty, Michael F.

doi:10.1205/026387604772992701

Cited by 22 publications

(17 citation statements)

References 25 publications

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“…Therefore, it is important to quickly estimate whether reactive distillation is a suitable process concept based on minimal information on the physical and chemical properties. As presented by Gadewar et al (2004), an effective way of decomposing the design and development of reactive distillation involves four stages. The first stage deals with the analysis of feasibility, that is, the analysis of possible top and bottom products.…”

Section: Introductionmentioning

confidence: 99%

The Structure of Water in p‐Sulfonatocalix[4]arene

Fucke

Anderson

Filby

et al. 2011

Chemistry A European J

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Tetrasodium p-sulfonatocalix[4]arene exists as a hydrate with approximately 14 water molecules and has three polymorphic modifications, all of which contain a water molecule in the molecular cavity that is engaged in OH···π interactions. Single-crystal neutron structures are reported for two of these three forms and reveal a "compressed" water molecule with short OH bonds. Partial atomic charges and hardness analysis (PACHA) calculations based on the neutron coordinates give an OH···π interaction energy of 6.9-7.5 kJ mol(-1). The PACHA analysis also reveals the dominance of the charge-assisted hydrogen bonds from the Na(+)-coordinated water molecules. The instability of the crystal towards dehydration can be traced to an uncoordinated lattice water site. The remarkable calixarene-Na(+)-hydrate motif is conserved almost unchanged across all three polymorphs. A single-crystal neutron structure is also reported for pentasodium p-sulfonatocalix[4]arene·12H(2)O, which exhibits an intracavity water molecule that is engaged in both OH···π and OH···O hydrogen bonding. The shorter covalent bond to the hydrogen atom that forms the interaction with the aromatic ring is again apparent.

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Section: Introductionmentioning

confidence: 99%

The Structure of Water in p‐Sulfonatocalix[4]arene

Fucke

Anderson

Filby

et al. 2011

Chemistry A European J

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“…A large number of contributions on plant-wide controllability analysis have been published, focusing on these problems. [188][189][190][191][192][193][194][195][196][197][198][199][200] Skogestad gave an excellent review and discussion of the design of a plant-wide control system and the concept of self-optimizing control. [201][202][203][204][205] Therefore, in this section, a brief discussion and an outline of recent progress will be given as follows.…”

Section: Sequential Design Methods For Improving the Plant-wide Contromentioning

confidence: 99%

An overview on controllability analysis of chemical processes

2011

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Controllability is one of the most important aspects of chemical process operability, because it can be used to assess the attainable operation of a given process and improve its dynamic performance. The purpose of this article is to outline the main methodologies that have been developed to deal with the assessment of process controllability and the improvement of its controllability characteristics. Several existing controllability assessment methods are reviewed and discussed. For improving the controllability characteristic of a process, there are two main design methods: the optimization-based method and the controllability indices-based anticipating sequential method. Advantages and disadvantages of these techniques are discussed. It has been emphasized that bifurcation analysis, as a powerful nonlinear analysis tool, could provide important guidance for making processes more controllable by eliminating or avoiding some undesirable behaviors of processes. Further challenges and developments in the field of process controllability are identified.

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“…These difficulties may be alleviated by taking the reaction zone out of the column and placing it in one or more separate reaction vessels connected to the column via liquid circulation loops. 26,39,40 The external reactor (or multiple reactors) can then be designed to operate at temperatures that differ from those in the distillation column and with longer liquidphase residence time. However, this closely coupled reactordistillation column configuration normally requires sizable additional vessels and heat exchangers that add to the capital and operating costs.…”

Section: Standard Column Designsmentioning

confidence: 99%

Horizontal reactive distillation for multicomponent chiral resolution

et al. 2013

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A novel horizontal reactive distillation apparatus and a new overall process scheme are proposed for continuous multicomponent chiral resolution via reversible enantioselective acylation of a chiral (racemic) substrate by a chiral (racemic) acyl donor. The process enables simultaneous production of up to four enantiomers with enhanced chiral purity. Kinetic studies, miniplant experiments, and process simulation results are described for a model lipase-catalyzed reaction: (R)-enantioselective transesterification of (R,S)-1-n-butoxy-2-propanol with (R,S)-1-methoxy-2-acetoxypropane to produce (R)-1-nbutoxy-2-acetoxypropane, (R)-1-methoxy-2-propanol, and the two unreacted (S)-enantiomers of the (R,S)-reagents. A horizontal, compartmentalized reactive distillation vessel is specified instead of a conventional reactive distillation column to provide longer liquid-phase residence time needed for adequate conversion. Low vapor-traffic pressure drop allows operation under vacuum at reduced temperatures for good enzyme stability and enantioselectivity. The general technology has potential as a means to producing a wide range of chiral synthons used in asymmetric syntheses of chiral pharmaceuticals and other biologically active products.

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Process Alternatives for Coupling Reaction and Distillation

Cited by 22 publications

References 25 publications

The Structure of Water in p‐Sulfonatocalix[4]arene

The Structure of Water in p‐Sulfonatocalix[4]arene

An overview on controllability analysis of chemical processes

Horizontal reactive distillation for multicomponent chiral resolution

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