Proceedings: The action of alpha-chlorohydrin (3-chloro-propane 1,2-diol) on the metabolism of glycerol in male rats

Em, Edwards; Ar, Jones; Gm, Waites

doi:10.1530/jrf.0.0350589

Cited by 3 publications

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“…The possibility that -chlorohydrin itself becomes incorporated into lipids has also been explored by the use of both [14C]-and [36C1] -chlorohydrin. Part of this work has already been reported in prelimin¬ ary form (Edwards, Jones & Waites, 1973). MATERIALS Jones (1973), and the [36C1] -chlorohydrin (sp.…”

Section: Introductionmentioning

confidence: 99%

The Entry of -Chlorohydrin Into Body Fluids of Male Rats and Its Effect Upon the Incorporation of Glycerol Into Lipids

Edwards¹,

Jones²,

Waites³

1975

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The rate of entry of alpha-chlorohydrin into rat rete testis fluid has been studied using the 14-C and 36-Cl-labelled compounds. The alpha-chlorohydrin crosses the blood-testis barrier and the concentration of radioactivity in rete testis fluid attained blood levels within 45 min. Within 3 hr of a single injection of [14-C] alpha-chlorohydrin, radioactivity was widely distributed in body fluids, and was present in the lipids of the brain, testis, epididymis and epididymal fat pads. No radioactivity was found in tissue lipids following the administration of [36-Cl] alpha-chlorohydrin, which suggests that dechlorination of this compound occurs before its incorporation. Neither a single high dose nor repeated low doses of alpha-chlorohydrin induced changes in the incorporation of [14-C] glycerol into lipids of the brain, testis, epididymis and epididymal fat pads.

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Section: Introductionmentioning

confidence: 99%