Proceedings of the WHO-NIEHS conference on potential environmental health hazards from technological developments in rubber and plastics industries. Research Triangle Park, N.C., March 1-3, 1976: Introductory statement.

This review summarizes studies concerning the covalent binding of [14C]TCE to rat liver microsomal protein and exogenous DNA, in vitro, the enhancement of this binding by inducers of mixed-function oxidases, and inhibition of binding by inhibitors of these enzymes. Furthermore, recent studies on this type of binding in various strains of mice and rats of both sexes and using microsomal preparations from various organs are briefly reviewed. Other work reviewed here concerns the synthesis of TCE epoxide and its reaction with nucleophiles since it is believed that TCE epoxide is the activated carcinogenic intermediate of TCE. The utility of structural prognostication of carcinogenic activity and the importance of considering possible metabolic pathways for other chlorinated olefins is also discussed.

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Development and Management of Toxicological Programs: Rationale for Testing: Opening Remarks

Hayes

1983

Journal of the American College of Toxicology

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Proceedings of the WHO-NIEHS conference on potential environmental health hazards from technological developments in rubber and plastics industries. Research Triangle Park, N.C., March 1-3, 1976: Introductory statement.

Cited by 3 publications

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Potential carcinogenic and mutagenic industrial chemicals. I. Alkylating agents

Potential carcinogenic and mutagenic industrial chemicals. I. Alkylating agents

Chemical structure, reactivity, and carcinogenicity of halohydrocarbons.

Development and Management of Toxicological Programs: Rationale for Testing: Opening Remarks

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