Proceedings of the Summit on Environmental Challenges to Reproductive Health and Fertility: executive summary

Woodruff, Tracey J.; Carlson, Alison; Schwartz, Jackie M.; Giudice, Linda C.

doi:10.1016/j.fertnstert.2007.10.002

Cited by 121 publications

(55 citation statements)

References 252 publications

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“…The difficulty in establishing the level of chemical expo sure in each geographic region, and the variety of com pounds existing simultaneously in the environment, the susceptibility and vulnerability of the host, and the long period of latency between exposure and characteriza tion of the individual responses are wellknown (32). Therefore, the limitations of this study, as in many oth ers, include the difficulty in proving causality, especially in an urban area without accidental or chronic popula tion exposure.…”

Section: Discussionmentioning

confidence: 94%

Organochlorine compound levels in fertile and infertile women from Rio de Janeiro, Brazil

Bastos

Souza

Filho

et al. 2013

Arq Bras Endocrinol Metab

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Objective: The aim of the study was quantify organochlorine compounds in women seeking for infertility treatment (n = 15) and in spontaneously pregnant ones (n = 21). Materials and methods: A questionnaire was applied regarding lifestyle, occupational and reproductive history. Blood samples were collected from both groups. Results: From the pesticides studied, pp'DDE was detected in 100% of infertile women, at higher mean levels than in pregnant women (3.02 mcg/L vs. 0.88 mcg/L; p = 0.001; power of 69%), without correlation with the etiology of infertility. Levels of the polychlorinated biphenyls (PCBs) were low, with positive samples in 100% in the infertile women for PCBs 138, 153, 180, while in pregnant women, they were 85.7% for congeners 138 and 153. Only PCB180 showed significance, with frequency of 71.4% (p = 0.019). Conclusions:The risk factors for female infertility were: age, consumption of untreated water and of canned foods. Exposure to the most prevalent organochlorine compounds described in literature was confirmed in the study, indicating that pp'DDE may adversely influence female fertility. Arq Bras Endocrinol Metab. 2013;57(5):346-53 Keywords Organochlorine pesticides; polychlorinated biphenyls; female fertility; endocrine disruptors RESUMO Objetivo: O estudo teve como objetivo quantificar as substâncias organocloradas em mulheres buscando tratamento para infertilidade (n = 15) e que espontaneamente engravidaram (n = 21). Materiais e métodos: Foi aplicado questionário considerando estilo de vida, história ocupacional e reprodutiva. Amostras de sangue foram obtidas em ambos os grupos. Resultados: Dos pesticidas, pp'DDE foi detectado em 100% das inférteis, com níveis maiores que nas grávidas (3,02 mcg/L vs. 0,88 mcg/L; p = 0,001; poder 69%), sem correlação na etiologia da infertilidade. Os níveis de detecção das bifenilas policloradas (PCBs) foram baixos, com 100% de positividade das amostras nas inférteis para os PCBs 138, 153, 180, e de 85,7% nas grávidas para os congêneres 138 e 153. Apenas PCB180 mostrou significância na frequência de 71,4% (p = 0,019). Conclusões: Os fatores de risco para infertilidade feminina foram: idade, consumo de água não tratada e alimentos enlatados. A exposição aos organoclorados mais prevalentes descritos na literatura foi confirmada no estudo, indicando que pp'DDE pode influenciar adversamente a fertilidade feminina. Arq Bras Endocrinol Metab. 2013;57(5):346-53 Descritores Pesticidas organoclorados; bifenilas policloradas; fertilidade feminina; desreguladores endócrinos

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Section: Discussionmentioning

confidence: 94%

Organochlorine compound levels in fertile and infertile women from Rio de Janeiro, Brazil

Bastos

Souza

Filho

et al. 2013

Arq Bras Endocrinol Metab

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“…Polychlorinated biphenyls are known to accumulate over time in men and were correlated with decreased sperm quality, especially reduced motility, whereas data about the relationship between pesticides or phthalates and human semen quality do not yet allow a definitive conclusion as highlighted in a recent review and the summary of an expert meeting about environmental challenges to reproductive health (Hauser, 2006;Woodruff et al, 2008). Air pollution was linked to increased DNA damage in human spermatozoa without affecting other semen parameters (Jafarabadi, 2007).…”

Section: Paternal Age and Toxicity/environmental Factorsmentioning

confidence: 99%

Paternal age and reproduction

Sartorius

Nieschlag

2009

Human Reproduction Update

289

212

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background: Due to various sociological factors, couples in developed countries are increasingly delaying childbearing. Besides ethical, economical and sociological issues, this trend presents us with several complex problems in reproduction. Although it is well-known that maternal age has a negative effect on fertility and increases the risk of adverse outcome during pregnancy and in offspring, the paternal influence on these outcomes is less well researched and not well-known.methods: We performed a systematic search of PubMed, and retrieved original articles and review articles to update our previous survey in this journal.results: This review highlights the link between male age and genetic abnormalities in the germ line and summarizes the knowledge about the effects of paternal age on reproductive function and outcome. Increasing paternal age can be associated with decreasing androgen levels, decreased sexual activity, alterations of testicular morphology and a deterioration of semen quality (volume, motility, morphology). Increased paternal age has an influence on DNA integrity of sperm, increases telomere length in spermatozoa and is suggested to have epigenetic effects. These changes may, at least in part, be responsible for the association of paternal age over 40 years with reduced fertility, an increase in pregnancy-associated complications and adverse outcome in the offspring. conclusion: Although higher maternal age can be an indication for intensive prenatal diagnosis, including invasive diagnostics, consideration of the available evidence suggests that paternal age itself, however, provides no rationale for invasive procedures.

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“…Environmental reproductive health focuses on exposures to environmental contaminants, particularly during critical periods of development, and their potential effects on future reproductive health, including conception, fertility, pregnancy, adolescent development and adult health (Woodruff et al, 2008).…”

Section: Link Between Genotoxic Responses and Reproductive Successmentioning

confidence: 99%

Amphibians as Model Organisms for Study Environmental Genotoxicity

Burlibaşa¹

2011

Appl Ecol Env Res

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Abstract. Animals, the silent sentinels, stand watch over the world's environmental health. Everyday, animals demonstrate intricate connections between them, us and our surroundings. Amphibians are vertebrates and include approximately 4400 existing species. Amphibians are in most cases, small, diverse and sensitive to environmental variability. They can be good indicators of habitat diversity, biological variety and local stressors on the environment. They are bathed in both water and air. They live outdoors on land and water and their skin, larvae and unshelled eggs are constantly exposed and in contact with the substances in their surroundings. We searched Web of Science and references of relevant publications to evidence the application of amphibians, especially Xenopus laevis as model animal in ecotoxicology.

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Proceedings of the Summit on Environmental Challenges to Reproductive Health and Fertility: executive summary

Cited by 121 publications

References 252 publications

Organochlorine compound levels in fertile and infertile women from Rio de Janeiro, Brazil

Organochlorine compound levels in fertile and infertile women from Rio de Janeiro, Brazil

Paternal age and reproduction

Amphibians as Model Organisms for Study Environmental Genotoxicity

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