Proceedings of the fourth international congress for stereology

Underwood, Erwin E; Wit, Ralph De; Moore, George A.

doi:10.6028/nbs.sp.431

Cited by 5 publications

(2 citation statements)

References 46 publications

(82 reference statements)

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“…In other words, the same spherical object of 50 µm true diameter, when viewed on a random 10 µm section can produce a circular section of the object that can vary from a few µm to 50 µm. Well known statistical distributions exist for the variation of sections of a sphere (46,47). Thus when the intrinsic variation of sections of a sphere are taken into account in the observed SP sectional size variation, the result is that SP size is considerably less variable than it appears.…”

Section: Overall Size Characteristics Of Spmentioning

confidence: 99%

Bursting Dense Microspheres (Spherons) in Alzheimer's Disease

Averback

Morse

Ghanbari

1998

JAD

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This paper reviews our research studies during the past 17 years on the relationship of cerebral protein dense microspheres (DMS), termed spherons, and senile plaques (SP) in the aged human brain and in AD. Initially, correlative anatomical and pathological data suggested that spherons may evolve into SP. This led to morphometric studies which strongly supported the theory. Biochemical studies were undertaken which showed that spherons could be isolated to homogeneity from brain tissue and contained the markers associated with SP. Experiments in vitro with spherons, and with inoculation of spherons into animals, reproduced SP lesion characteristics. To test the validity of using spherons for drug screening, experimental drugs were tested, a few of which are capable of blocking the formation of spheron-induced experimental SP.

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Section: Overall Size Characteristics Of Spmentioning

confidence: 99%

Bursting Dense Microspheres (Spherons) in Alzheimer's Disease

Averback

Morse

Ghanbari

1998

JAD

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“…The reader interested in exploring stereology, both theoretical and applied, may consult Elias (1967), DeHoff and Rhines (1968), Underwood (1970), Weibel et a/. (1972) or Underwood et al (1976).…”

Section: Introductionmentioning

confidence: 99%

Sampling Theory for Opaque Spatial Specimens

Davy

Miles

1977

Journal of the Royal Statistical Society Series B: Statistical Methodology

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Procedures for inferring the internal geometric structure of an opaque bounded n-dimensional set by random sectioning are discussed. General conditions are given (evidently for the first time) for the validity of the so-called "fundamental formulae" of stereo logy (the science of inferring spatial structure from lower dimensional data). In technical terms, a wide class of unbiased ratio estimators, based on the traces of embedded features in appropriately weighted random sections, is presented.

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Stereology: A Survey for Geometers

Weil

1983

Convexity and Its Applications

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Proceedings of the fourth international congress for stereology

Abstract: I am confident that the readers of these Proceedings will find something of interest, whether basic or advanced, old or new, routine or stimulating, and that all will profit from a more extensive use of the powerful, yet elegantly simple, relationships of stereology.

Cited by 5 publications

References 46 publications

Bursting Dense Microspheres (Spherons) in Alzheimer's Disease

Bursting Dense Microspheres (Spherons) in Alzheimer's Disease

Sampling Theory for Opaque Spatial Specimens

Stereology: A Survey for Geometers

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