PROCEEDINGS OF THE British Pharmacological Society

Cox, Sharon Natasha; Pesce, Francesco; Moustafa, Julia S. El-Sayed; Sallustio, Fabio; Serino, Grazia; Kkoufou, C; Giampetruzzi, Annalisa; Ancona, Nicola; Falchi, Mario; Fp, Schena

doi:10.1111/j.1476-5381.1975.tb07634.x

Cited by 2 publications

(2 citation statements)

References 249 publications

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“…Interestingly, none of the other products of COX metabolism were found to be elevated in the WM group. PGD1 has been shown to reduce vascular permeability induced by other prostaglandins [26] and have anti-inflammatory effects in atopic dermatitis [27]. Further, PGD1 has been shown to be generated by murine macrophages when incubated with DGLA and stimulated with lipopolysaccharide [25].…”

Section: Discussionmentioning

confidence: 99%

“…We were unable to find much information on PGD1 in the literature, particularly its role in the brain. However, at least in relation to atopic dermatitis, it appears that it may be an anti-inflammatory mediator which is induced by inflammatory stimuli as a potential feedback mechanism [25,26,27]. The cytochrome p450 epoxygenases can epoxidize any of the four double bonds of arachidonic acid (AA) producing one of the following: 5,6-EpETrE, 8,9-EpETrE, 11,12-EpETrE, or 14,15-EpETrE [28].…”

Section: Discussionmentioning

confidence: 99%

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A single meal has the potential to alter brain oxylipin content

Norman

Aung

Otoki

et al. 2020

Prostaglandins, Leukotrienes and Essential Fatty Acids

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Our objective was to determine whether consumption of a single meal has the potential to alter brain oxylipin content. We examined the cerebrum of mice fed a single high-fat/high-sucrose Western meal or a low-fat/lowsucrose control meal, as well as fasted mice. We found no changes in fatty acid composition of cerebrum across the groups. The cerebral oxylipin profile of mice fed a Western meal is distinct from the profile of mice fed a lowfat/low-sucrose meal. Cerebral gene expression of cyclooxygenase 1, cyclooxygenase 2, and epoxide hydrolase 1 were elevated in Western meal-fed mice compared to low-fat/low-sucrose meal-fed mice. Mice that consumed either meal had lower gene expression of cytochrome P450, family 2, subfamily j, polypeptide 12 than fasted mice. Our data in this hypothesis-generating study indicates that the composition of a single meal has the potential to alter brain oxylipins and the gene expression of the enzymes responsible for their production.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A single meal has the potential to alter brain oxylipin content

Norman

Aung

Otoki

et al. 2020

Prostaglandins, Leukotrienes and Essential Fatty Acids

View full text Add to dashboard Cite

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Supplementation of Dihomo-γ-Linolenic Acid for Pollen-Induced Allergic Symptoms in Healthy Subjects: A Randomized, Double-Blinded, Placebo-Controlled Trial

2023

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Dihomo-γ-linolenic acid (DGLA) is an n-6 polyunsaturated fatty acid that has been shown to have anti-inflammatory and anti-allergic effects in mice and cell study. To date, however, no human intervention study has examined the effects of DGLA. Therefore, we investigated the effects of DGLA on pollen-induced allergic symptoms in healthy adults. We performed a randomized, double-blind, placebo-controlled, parallel-group study comprising healthy Japanese men and women. Each subject received four 250 mg capsules providing 314 mg DGLA/day (DGLA group, n = 18) or olive oil (placebo group, n = 15) for 15 weeks. The primary outcomes, classification of the severity of allergic rhinitis symptoms (CSARS), and the Japanese Rhino-conjunctivitis Quality of Life Questionnaire (JRQLQ) served as symptom scores during the pollen season. In the DGLA group, the cedar pollen associated symptoms of sneezing and a blocked nose in the CSARS were significantly lower than those in the placebo group (p < 0.05, p < 0.01, respectively). Significant trends were observed the symptoms of runny nose in the CSARS and total symptom score (TSS) in the JRQLQ for cedar pollen (p < 0.1). To our knowledge, this is the first study to report the effects of DGLA in humans, and the results suggest that DGLA is effective in reducing allergic symptoms caused by pollen.

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PROCEEDINGS OF THE British Pharmacological Society

Cited by 2 publications

References 249 publications

A single meal has the potential to alter brain oxylipin content

A single meal has the potential to alter brain oxylipin content

Supplementation of Dihomo-γ-Linolenic Acid for Pollen-Induced Allergic Symptoms in Healthy Subjects: A Randomized, Double-Blinded, Placebo-Controlled Trial

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