Proceedings: Hormonal changes occurring in cattle following the administration of prostaglandin F 2alpha

Nancarrow, C. D.; Hearnshaw, H; Pe, Mattner; Pj, Connell; Bj, Restall

doi:10.1530/jrf.0.0360484

Cited by 11 publications

(6 citation statements)

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“…These results suggest either that the dose levels of prostaglandin used were insufficient to affect luteolysis or, more likely, that placental progesterone production was sufficient to prevent the action of prostaglandin causing complete disappearance of progesterone from the circulation. It seems unlikely that the dose levels used were insufficient as such levels have been found to be luteolytic in sheep and cattle (Boland, Lemainque & Gordon, 1978;Nancarrow et al 1974). Although litter size varied between the treatment groups it did not affect the outcome.…”

Section: Methodsmentioning

confidence: 95%

Induction of lambing: comparison of the effects of prostaglandin, oestradiol benzoate and dexamethasone

Boland¹,

Crosby²,

Gordon³

1982

J. Agric. Sci.

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In the first of two experiments 45 ewes were treated on day 141 of gestation with either prostaglandin F 2 a or saline. Doses of 10, 15, 20 or 25 mg PGF 2a failed to induce lambing earlier than in control animals. A further 50 ewes were similarly treated on day 144; neither dose level of PGF aa nor day of administration had any effect on the interval from injection to lambing compared with controls. In a second experiment 159 ewes were randomly assigned to one of four treatment groups as follows: (1) 20 mg oestradiol benzoate (ODB); (2) 16 mg dexamethasone; (3) 15 mg PGF 2a ; (4) 2 ml saline. Ewes were injected on either day 143 or 144 of gestation and on each of those days animals were injected either in the morning or evening. The mean times to induction of lambing were 38-6 + 20-8; 44-2+18-1; 83-5±39-8 and 82-9±43-lh for the four treatments respectively. Neither day nor time of treatment had any significant effect on the interval to lambing. Both ODB and dexamethasone induced parturition earlier than PGF 2a or saline (P < 005).

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Section: Methodsmentioning

confidence: 95%

Induction of lambing: comparison of the effects of prostaglandin, oestradiol benzoate and dexamethasone

Boland¹,

Crosby²,

Gordon³

1982

J. Agric. Sci.

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“…In the present studies, PGF-2a was used to synchronize the oestrous cycles of heifers with palpable corpora lutea (CL). Although progesterone production by the CL declines rapidly and synchronously after PGF-2a the subsequent onset of oestrus may be more variable (Nancarrow, Hearnshaw, Mattner, Connell & Restall, 1974). Our hypothesis was that if synchrony of oestrus in cows is mediated by pheromones secreted by oestrous cows, then exposure to secretions containing those pheromones would increase the synchronization of oestrus obtained after PGF-2ct administration.…”

Section: Introductionmentioning

confidence: 94%

Priming pheromones from oestrous cows increase synchronization of oestrus in dairy heifers after PGF-2 injection

Izard¹,

Vandenbergh²

1982

Reproduction

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Post-pubertal Holstein heifers with palpable corpora lutea were injected i.m. with 25 mg PGF-2\g=a\to bring all animals to the follicular phase of the oestrous cycle. After 3 oronasal treatments with secretions from oestrous cows or water, heifers were observed for oestrus and inseminated about 12 h after the onset of oestrus. In Exp. I, heifers were treated with water or a mixture of urine and cervical mucus from oestrous cows at 6, 30 and 56 h after the PGF-2\g=a\ injection. The percentage of heifers in oestrus within 72 h after PGF-2\g=a\was 86% for urine + cervical mucus-treated heifers and 60% for water-treated heifers (P > 0\m=.\05).Days to oestrus and conception rate after A.I. did not differ between the treatments. The degree of synchrony of oestrus after PGF-2\g=a\was significantly greater (P < 0\m=.\05) in the animals receiving urine + mucus treatment. In Exp. II, urine and cervical mucus from oestrous cows were separately tested in comparison to water. Test substances were applied at the time of PGF-2\g=a\injection, and 6 and 30 h later. The percentage of heifers in oestrus within 72 h after PGF-2\g=a\ (100%) was highest (P < 0\m=.\05) in the cervical mucus-treated heifers but the conception rate (24%) was the lowest. The days to oestrus did not differ amongst groups but the degree of synchrony of oestrus after PGF-2\g=a\ was greatest (P < 0\m=.\05) in animals treated with cervical mucus. These data indicate that a priming pheromone in the cervical mucus of oestrous cows can affect the ovarian function of herdmates and thereby improve synchrony of oestrus after PGF-2\g=a\injection.

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“…Following luteolysis, endogenous gonadotropins surge, culminating in ovarian follicular development, oestrogen production and subsequently oestrus manifestion (Nancarrow et al 1974). It would appear from this study that these events take a shorter time in Borans than in cross-breds.…”

Section: Discussionmentioning

confidence: 65%

Luteolytic effect of prostaglandin F_2α in Boran and Boran × Friesian cross-bred heifers

Mutiga¹,

Mukasa-Mugerwa²,

Azage³

1993

J. Agric. Sci.

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S U M M A R YThe luteolytic effect of prostaglandin F 2a (PGF 2a ) during the confirmed luteal phase of the oestrous cycle was evaluated in ten Boran and ten Boran x Friesian cross-bred heifers. Following injection with 25 mg Lutalyse, animals were bled every 6 h for 96 h and plasma progesterone (P 4 ) determined by the ELISA technique. Borans had significantly (P < 0-05) smaller corpora lutea (1201 ±0-72 v. 17-03 ±2-10 mm) and responded faster to PGF 2a injection (65-57+1-40 v. 78-27 + 218 h) than the cross-bred heifers. However, there was no significant difference in either the initial P 4 values (6.24 + 0-98 v. 8-00 ± 1-71 ng/ml) or the rate of its decline following PGF 2a injection between the two breeds. Values declined sharply to basal levels (11 % of the initial pretreatment values) within 48 h in both breeds. All ten cross-breds and eight Borans showed standing oestrus within a week of treatment. However, oestrus was better synchronized (P < 005) in Borans than cross-breds. It was concluded that PGF 2a is effective for oestrus synchronization in both breeds, but oestrus occurred earlier and was more precise in Borans than in cross-breds.

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Proceedings: Hormonal changes occurring in cattle following the administration of prostaglandin F 2alpha

Cited by 11 publications

References 0 publications

Induction of lambing: comparison of the effects of prostaglandin, oestradiol benzoate and dexamethasone

Induction of lambing: comparison of the effects of prostaglandin, oestradiol benzoate and dexamethasone

Priming pheromones from oestrous cows increase synchronization of oestrus in dairy heifers after PGF-2 injection

Luteolytic effect of prostaglandin F_2α in Boran and Boran × Friesian cross-bred heifers

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Proceedings: Hormonal changes occurring in cattle following the administration of prostaglandin F 2alpha

Cited by 11 publications

References 0 publications

Induction of lambing: comparison of the effects of prostaglandin, oestradiol benzoate and dexamethasone

Induction of lambing: comparison of the effects of prostaglandin, oestradiol benzoate and dexamethasone

Priming pheromones from oestrous cows increase synchronization of oestrus in dairy heifers after PGF-2 injection

Luteolytic effect of prostaglandin F2α in Boran and Boran × Friesian cross-bred heifers

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Luteolytic effect of prostaglandin F_2α in Boran and Boran × Friesian cross-bred heifers